Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates\; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010].
Li, Yao, Xu, Pesenti, Cottet-Rousselle, Rieusset, Tokarska-Schlattner, Liao, Schlattner, Rousseau: "ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte-like 3T3-L1 cells." in: Molecular and cellular biology, (2014) (PubMed).
Valenti, Tullo, Caratozzolo, Merafina, Scartezzini, Marra, Vacca: "Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy." in: The Biochemical journal, Vol. 431, Issue 2, pp. 299-310, (2010) (PubMed).