(ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 (ADAMTS18))
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Reddy, Fernandes, Deshpande, Weisberg, Inguilizian, Abdel-Wahab, Kung, Levine, Griffin, Sattler: "The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity." in: Leukemia, Vol. 26, Issue 3, pp. 481-9, (2012) (PubMed).
Aldahmesh, Khan, Mohamed, Alkuraya, Ahmed, Bobis, Al-Mesfer, Alkuraya: "Identification of ADAMTS18 as a gene mutated in Knobloch syndrome." in: Journal of medical genetics, Vol. 48, Issue 9, pp. 597-601, (2011) (PubMed).
Aliases for ADAMTS18 抗体
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18 (Adamts18) 抗体 ADAM metallopeptidase with thrombospondin type 1 motif 18 (ADAMTS18) 抗体 ADAM metallopeptidase with thrombospondin type 1 motif, 18 (Adamts18) 抗体 9630038L21 抗体 ADAMTS21 抗体 E130314N14Rik 抗体 KNO2 抗体 RGD1560118 抗体