This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme\; binds mitotic arrest deficient 2 protein\; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008].
Wang, Huang, Nayak, Matthews, Warburton, Shi, Sanchez-Esteban: "Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin ?6?1-ADAM17/tumor necrosis factor-?-converting enzyme (TACE) signaling pathway." in: The Journal of biological chemistry, Vol. 288, Issue 35, pp. 25646-57, (2013) (PubMed).
Aliases for ADAM17 蛋白
ADAM metallopeptidase domain 17 (ADAM17) 蛋白 a disintegrin and metallopeptidase domain 17 (Adam17) 蛋白 ADAM metallopeptidase domain 17b (adam17b) 蛋白 ADAM metallopeptidase domain 17 L homeolog (adam17.L) 蛋白 ADAM metallopeptidase domain 17 (Adam17) 蛋白 ADAM metallopeptidase domain 17a (adam17a) 蛋白 adam17 蛋白 ADAM18 蛋白 adam18 蛋白 CD156B 蛋白 CD156b 蛋白 cd156b 蛋白 CSVP 蛋白 csvp 蛋白 fc20b01 蛋白 NISBD 蛋白 si:dkey-81b15.2 蛋白 TACE 蛋白 Tace 蛋白 tace 蛋白 wu:fc20b01 蛋白 zgc:63886 蛋白