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抗Rat (Rattus) MMP2 抗体:
抗Mouse (Murine) MMP2 抗体:
抗Human MMP2 抗体:
Chicken Polyclonal MMP2 Primary Antibody for ICC, IF - ABIN152329
Krekoski, Neubauer, Graham, Muir: Metalloproteinase-dependent predegeneration in vitro enhances axonal regeneration within acellular peripheral nerve grafts. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
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Human Polyclonal MMP2 Primary Antibody for IF (p), IHC (p) - ABIN668286
Wu, Fan, Zhang, Ning, Zeng, Zhou, Li, Chen, Zhang, Wang, Hsieh, He: PI3K/Akt to GSK3?/?-catenin signaling cascade coordinates cell colonization for bladder cancer bone metastasis through regulating ZEB1 transcription. in Cellular signalling 2012
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Human Monoclonal MMP2 Primary Antibody for ICC, IHC (fro) - ABIN152258
Locke, Royce, Wainewright, Samuel, Tang: Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease. in American journal of respiratory cell and molecular biology 2007
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Cow (Bovine) Polyclonal MMP2 Primary Antibody for IHC, ELISA - ABIN1582259
Seet, Su, Barathi, Lee, Poh, Heng, Manser, Vithana, Aung, Weaver, Sage, Wong: SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery. in PLoS ONE 2010
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Human Polyclonal MMP2 Primary Antibody for IF (p), IHC (p) - ABIN707426
Cavdar, Ozbal, Celik, Ergur, Guneli, Ural, Camsari, Guner: The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model. in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2014
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Guinea Pig Monoclonal MMP2 Primary Antibody for ELISA, ICC - ABIN152257
Rork, Hadzimichalis, Kappil, Merrill: Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium. in Journal of molecular and cellular cardiology 2006
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Human Monoclonal MMP2 Primary Antibody for ELISA, WB - ABIN1098146
Langers, Verspaget, Hawinkels, Kubben, van Duijn, van der Reijden, Hardwick, Hommes, Sier: MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients. in British journal of cancer 2012
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Human Monoclonal MMP2 Primary Antibody for ELISA, ICC - ABIN451535
Siddesha, Valente, Yoshida, Sakamuri, Delafontaine, Iba, Noda, Chandrasekar: Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration. in Cellular signalling 2014
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Human Monoclonal MMP2 Primary Antibody for CyTOF, FACS - ABIN4900818
Zhao, McCloud, Fleming, Klempner: Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro. in Biochemical and biophysical research communications 2007
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Human Polyclonal MMP2 Primary Antibody for WB - ABIN657616
Shi, Shang, Pan, Wang, Jiang, Hao, Zhang, Cai, Xu, Zhan, Wang: Calreticulin promotes migration and invasion of esophageal cancer cells by upregulating neuropilin-1 expression via STAT5A. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
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study demonstrated that matrix metalloproteinase 1 (显示 MMP1 抗体) and 2 might be fundamental for events related to equine tissue remodeling, which occurs during follicular development
inhibition of ECM (显示 MMRN1 抗体) degradation by inhibition of matrix metalloproteinase 2 (Mmp2) to preserve the extracellular environment characteristics of young adults led to increased dendrite regeneration
Data indicate that matrix metalloproteinases mmp1 (显示 MMP1 抗体) and mmp2 mutants have distinct heart phenotypes.
We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2 (显示 CA2 抗体)+ as the second messenger.
Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells.
As a Wnt (显示 WNT4 抗体) signaling antagonist, MMP2 cleaves the glypican (显示 GPC1 抗体), reducing the ability of Dlp (显示 DMD 抗体) to interact with the Wnt (显示 WNT4 抗体) ligand and promote its distribution.
Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila
Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.
Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes
Mmp2 expression in the developing air sac (显示 ADCY10 抗体) is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling.
findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix
Mmp2 facilitates endothelial-to-hematopoietic transition via ECM (显示 MMRN1 抗体) remodeling.
Dexamethasone and hydrocortisone alter expression and activity of MMP-2 and MMP-9 (显示 MMP9 抗体) in the embryonic zebrafish.
In obese mice, periodontitis caused the downregulation of MMP2, and upregulation of TIMP1 (显示 TIMP1 抗体) and TGF-beta1 (显示 TGFB1 抗体) at transcriptional and translational levels.
In the initial periods of AP progression, an increased expression of MMP9 (显示 MMP9 抗体) in the TLR2 KO and MyD88 (显示 MYD88 抗体) KO mice was observed. In the final periods of AP progression, a reduction of MMP2 expression and an increase of MMP9 (显示 MMP9 抗体) expression in the TLR2 KO mice were observed. MMP2 and MMP9 (显示 MMP9 抗体) production was modulated for TLR2 and MyD88 (显示 MYD88 抗体) during apical periodontitis progression
MMP-2 promoted and MMP-13 (显示 MMP13 抗体) disrupted vasculogenic mimicry formation in large cell lung cancer by cleaving laminin-5 to influence EGFR (显示 EGFR 抗体) signal activation.
Diet and exercise affect atheromatous MMP2/9 activity by modulating the systemic inflammatory milieu, with sVCAM-1, resistin, and adiponectin closely interacting with each other and with visceral fat.
calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2/TGF-beta1 (显示 TGFB1 抗体) pathway.
Aneurysmal-prone factors induced HIF-1alpha (显示 HIF1A 抗体) can cause overexpression of MMP-2 and MMP-9 (显示 MMP9 抗体) and promote aneurysmal progression.
These studies illustrated an important role of MMP2 in cognitive and motor behaviors and confirm its importance in NPC (显示 NPC1 抗体) activities crucial to brain development, growth and response to and recovery from injury.
Secretagogin (显示 SCGN 抗体)-dependent MMP2 release from neurons regulates neuroblast migration.
matrix metalloproteinase 2 (Mmp2) transcript is a target of miR (显示 MLXIP 抗体)-195a-3p, and that silencing Mmp2 phenocopied the reduced proliferation and migration of MSCs. The therapeutic potential of miR (显示 MLXIP 抗体)-195a-3p as an angiogenesis inhibitor was also demonstrated in a laser-induced choroidal neovascularization mouse model.
developed a novel selective radiolabeled MMP2/9 inhibitor, suitable for single photon emission computed tomography (SPECT) imaging that effectively targets atherosclerotic lesions in mice
We conclude that S1P (显示 MBTPS1 抗体) attenuates the invasion of C643 cells by activating S1P2 (显示 S1PR2 抗体) and the Rho-ROCK pathway, by decreasing calpain activity, and by decreasing the expression, secretion and activity of MMP2 and, to a lesser extent, MMP9 (显示 MMP9 抗体). Our results thus unveil a novel function for the S1P2 (显示 S1PR2 抗体) receptor in attenuating thyroid cancer cell invasion.
High mmp2 expression is associated with ovarian cancer cell migration and invasion.
MMP-2 was expressed in high percentage of endometrial cancer and its expression may be associated closely with clinical stage, and tumor invasion and metastasis, indicating that MMP-2 overexpression may serve as a predictive factor for poor prognosis of endometrial cancer.
MMP2 single nucleotide polymorphisms association with lymphedema caused by Wuchereria bancrofti.
High MMP2 expression is associated with esophageal squamous cell carcinoma.
Data suggest that environmental carcinogen PFOA (perfluorooctanoic acid) stimulates ovarian cancer cell migration, invasion, and MMP2/MMP9 expression by up-regulating ERK/NFkappaB signaling pathway. (MMP = matrix metallopeptidase; NFkappaB = nuclear factor kappa B)
Matrix-metalloproteinase-2 is implicated in the pathophysiological mechanism of stenosis development and has a predictive value for arteriovenous fistula failure in hemodialysis patients
Fli1 (显示 FLI1 抗体) functioned as an oncogene (显示 RAB1A 抗体) in HCC (显示 FAM126A 抗体) carcinogenesis and it exerted its promoting metastatic effect primarily by modulating the matrix metalloproteinase (MMP)2 signaling pathway.
Rictor (显示 RICTOR 抗体) regulates the vasculogenic mimicry of melanoma and determines the patients' survival via the AKT (显示 AKT1 抗体)-MMP2-MMP9 (显示 MMP9 抗体) pathway.
this study shows that differential FFAR1 (显示 FFAR1 抗体) signaling is associated with gene expression or gelatinase granule release in bovine neutrophils
NADPH oxidase (显示 NOX1 抗体) plays an important role in proMMP-2 expression and activation and MMP-2 mediated SMC (显示 DYM 抗体) proliferation occurs through the involvement of Spm (显示 NPC1 抗体)-Cer (显示 CBLN1 抗体)-S1P (显示 MBTPS1 抗体) signaling axis under ANG II (显示 AGT 抗体) stimulation of PASMCs
The expression patterns of MMP1 (显示 MMP1 抗体), MMP2, and MMP8 (显示 MMP8 抗体) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1 (显示 MMP1 抗体), MMP2, and MMP8 (显示 MMP8 抗体) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1 (显示 MMP1 抗体), MMP2, and MMP8 (显示 MMP8 抗体) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.
The results showed that a decrease in MMP-1 (显示 MMP1 抗体) and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.
Activation of cytosolic MMP-9 (显示 MMP9 抗体) and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
Data indicate the involvement of PKC-alpha (显示 PKCa 抗体) in proMMP-2 activation and inhibition of TIMP-2 (显示 TIMP2 抗体) expression by NF-kappaB (显示 NFKB1 抗体)-MT1-MMP (显示 MMP14 抗体)-dependent and -independent pathway.
Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2; MMP-14 (显示 MMP14 抗体)) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.
Adding pure bovine MMP-2 to the smooth muscle membrane suspension causes an increase in Ca(2+)-ATPase (显示 CA-P60A 抗体) activity, but the pretreatment with TIMP-2 (显示 TIMP2 抗体) inhibits the increase in the enzyme activity
A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.
MMP-14 (显示 MMP14 抗体), MMP-2 and TIMP-2 (显示 TIMP2 抗体) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (显示 MMP9 抗体), TIMP1 (显示 TIMP1 抗体), and NGAL (显示 LCN2 抗体) (also MMP2 in 220 kDa complex) without proteolytic activity.
Data demonstrate for the first time that MMP2 and MMP9 (显示 MMP9 抗体) are expressed in swine ovarian follicle both in theca and granulosa layers.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (显示 MMP9 抗体) and MMP-2, caspase-3 (显示 CASP3 抗体) and BDNF (显示 BDNF 抗体)
MMP-2 may play an important role in regulating MLC1 turnover in the heart under normal physiological conditions
Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.
PI3K-dependent regulation of MT1-MMP (显示 MMP14 抗体) protein synthesis and subsequent activation of latent MMP-2 as critical events in neointimal hyperplasia after vascular injury.
MMP-2 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis
contribution of MMPs to the inflammatory breakdown of the blood-CSF (显示 CSF2 抗体) barrier in vitro
The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 (显示 MMP9 抗体) in the corpus luteum of swine during luteolysis are reported.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (显示 VEGFA 抗体), pro-MMP-9 (显示 MMP9 抗体), MMP-2, VEGFR-1 (显示 FLT1 抗体), VEGFR-2 (显示 KDR 抗体), and TIMP-1 (显示 TIMP1 抗体), which may contribute to the development of venous stenosis.
Selenium suppressed high-fat diet-induced MMP2 over-expression in vivo by improving lipid metabolism.
Inflammatory factors such as TNF-alpha (显示 TNF 抗体) can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases
Results provide evidence that MMP-2 bears the potentiality to cleave alpha-DG enriched from rabbit skeletal muscle indicating that this degradation indeed might also occur in vivo.
In conclusion, MMP-2 could be responsible for the proteolysis of dystrophin (显示 DMD 抗体).
Castor (显示 CASZ1 抗体) oil polymer induces bone formation with high matrix metalloproteinase-2 expression.
MMP2 spinal cord expression is increased in cervical spondylotic myelopathy.
Ulinastatin (显示 AMBP 抗体) effectively inhibited the increased expression of MMP-2, MMP-3 (显示 MMP3 抗体), and iNOS (显示 NOS2 抗体) in degenerated NP cells induced by IL-1beta (显示 IL1B 抗体) in vitro.
Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 (显示 MMP9 抗体) and TIMP-1 (显示 TIMP1 抗体) in rabbits with acute paraquat poisoning.
The RNA interference targeting COX-2 (显示 COX2 抗体) can effectively inhibit the expression of COX-2 (显示 COX2 抗体) and MMP-2 in IL-1alpha stimulated rabbit corneal stromal cells in vitro.
Our results strongly suggest that ischaemic postconditioning may exert part of its cardioprotective effects through the inhibition of MMP-2 activity.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
, matrix metalloprotease 2
, matrix metalloproteinase
, matrix metalloproteinase 2
, 72 kDa type IV collagenase
, Gelatinase A
, matrix metalloproteinase-2
, 72 kDa gelatinase
, gelatinase A
, 72kD gelatinase
, 72kD type IV collagenase
, 72kDa gelatinase
, 72kDa type IV collagenase
, collagenase type IV-A
, matrix metalloproteinase-II
, neutrophil gelatinase
, matrix metalloproteinase 2 (72 KDa type IV collagenase)
, matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)