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抗Rat (Rattus) MMP2 抗体:
抗Mouse (Murine) MMP2 抗体:
抗Human MMP2 抗体:
Chicken Polyclonal MMP2 Primary Antibody for ICC, IF - ABIN152329
Krekoski, Neubauer, Graham, Muir: Metalloproteinase-dependent predegeneration in vitro enhances axonal regeneration within acellular peripheral nerve grafts. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
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Human Monoclonal MMP2 Primary Antibody for ICC, IHC (fro) - ABIN152258
Locke, Royce, Wainewright, Samuel, Tang: Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease. in American journal of respiratory cell and molecular biology 2007
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Human Polyclonal MMP2 Primary Antibody for IF (p), IHC (p) - ABIN668286
Wu, Fan, Zhang, Ning, Zeng, Zhou, Li, Chen, Zhang, Wang, Hsieh, He: PI3K/Akt to GSK3?/?-catenin signaling cascade coordinates cell colonization for bladder cancer bone metastasis through regulating ZEB1 transcription. in Cellular signalling 2012
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Cow (Bovine) Polyclonal MMP2 Primary Antibody for IHC, ELISA - ABIN1582259
Seet, Su, Barathi, Lee, Poh, Heng, Manser, Vithana, Aung, Weaver, Sage, Wong: SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery. in PLoS ONE 2010
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Human Polyclonal MMP2 Primary Antibody for IF (p), IHC (p) - ABIN707426
Cavdar, Ozbal, Celik, Ergur, Guneli, Ural, Camsari, Guner: The effects of alpha-lipoic acid on MMP-2 and MMP-9 activities in a rat renal ischemia and re-perfusion model. in Biotechnic & histochemistry : official publication of the Biological Stain Commission 2014
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Guinea Pig Monoclonal MMP2 Primary Antibody for ELISA, ICC - ABIN152257
Rork, Hadzimichalis, Kappil, Merrill: Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium. in Journal of molecular and cellular cardiology 2006
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Human Monoclonal MMP2 Primary Antibody for ELISA, WB - ABIN1098146
Langers, Verspaget, Hawinkels, Kubben, van Duijn, van der Reijden, Hardwick, Hommes, Sier: MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients. in British journal of cancer 2012
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Human Monoclonal MMP2 Primary Antibody for ELISA, ICC - ABIN451535
Siddesha, Valente, Yoshida, Sakamuri, Delafontaine, Iba, Noda, Chandrasekar: Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration. in Cellular signalling 2014
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Human Polyclonal MMP2 Primary Antibody for WB - ABIN657616
Shi, Shang, Pan, Wang, Jiang, Hao, Zhang, Cai, Xu, Zhan, Wang: Calreticulin promotes migration and invasion of esophageal cancer cells by upregulating neuropilin-1 expression via STAT5A. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
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Cow (Bovine) Polyclonal MMP2 Primary Antibody for IHC, WB - ABIN2792308
Collier, Wilhelm, Eisen, Marmer, Grant, Seltzer, Kronberger, He, Bauer, Goldberg: H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen. in The Journal of biological chemistry 1988
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study demonstrated that matrix metalloproteinase 1 (显示 MMP1 抗体) and 2 might be fundamental for events related to equine tissue remodeling, which occurs during follicular development
Data indicate that matrix metalloproteinases mmp1 (显示 MMP1 抗体) and mmp2 mutants have distinct heart phenotypes.
We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2 (显示 CA2 抗体)+ as the second messenger.
Finally, matrix metalloproteinase 2 (Mmp2), a type of protease thought to facilitate mammalian ovulation, is expressed in mature follicle and corpus luteum cells.
As a Wnt (显示 WNT4 抗体) signaling antagonist, MMP2 cleaves the glypican (显示 GPC1 抗体), reducing the ability of Dlp (显示 DMD 抗体) to interact with the Wnt (显示 WNT4 抗体) ligand and promote its distribution.
Matrix metalloproteinase 2 is required for fat-body remodeling in Drosophila
Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila.
Dendrite reshaping of adult Drosophila sensory neurons requires matrix metalloproteinase MMP2-mediated modification of the basement membranes
Mmp2 expression in the developing air sac (显示 ADCY10 抗体) is controlled by the Drosophila FGF homolog Branchless and then participates in a negative feedback and lateral inhibition mechanism that defines the precise pattern of FGF signaling.
findings demonstrate a critical role for Mmp2 in tubulogenesis post-induction, and implicate Mmp2 in regulating dynamic and essential changes to the extracellular matrix
Dexamethasone and hydrocortisone alter expression and activity of MMP-2 and MMP-9 (显示 MMP9 抗体) in the embryonic zebrafish.
matrix metalloproteinase 2 (Mmp2) transcript is a target of miR (显示 MLXIP 抗体)-195a-3p, and that silencing Mmp2 phenocopied the reduced proliferation and migration of MSCs. The therapeutic potential of miR (显示 MLXIP 抗体)-195a-3p as an angiogenesis inhibitor was also demonstrated in a laser-induced choroidal neovascularization mouse model.
developed a novel selective radiolabeled MMP2/9 inhibitor, suitable for single photon emission computed tomography (SPECT) imaging that effectively targets atherosclerotic lesions in mice
MMP-2 and MMP-9 (显示 MMP9 抗体) have roles in early stages of experimental autoimmune encephalomyelitis induction; MMP-9 (显示 MMP9 抗体) from an immune cell source is required in EAE for initial infiltration of leukocytes into the central nervous system
This study illustrated that tumour-derived MMP2 has at least two roles in tumour malignancy; to enhance tumour invasiveness by degrading the extracellular matrix and to enhance tumour growth by promoting vessel maturation and function.
MMP-2 and -9 expression were suppressed significantly by treatment with SB-3CT. The data demonstrated, for the first time, that SB-3CT strongly reduced corneal lymphangiogenesis and macrophage infiltration during inflammation.
animals were submitted to the evaluation of Blood-Brain Barrier permeability and MMP-2 and MMP-9 (显示 MMP9 抗体) in striatum, hippocampus and cerebral cortex
High MMP2 expression is associated with abdominal aortic aneurysm.
Low MMP2 expression is associated with liver fibrosis.
Cleavage of beta-DG still occurred when both MMP-2 and MMP-9 (显示 MMP9 抗体) were knocked out in gamma - sarcoglycan (显示 SGCG 抗体)-deficient mice. The study found that up-regulation of MMP-14 (显示 MMP14 抗体) is capable of cleaving beta-DG, and it may be involved in the pathogenesis of sarcoglycanopathy.
NH2-terminal truncated MMP-2 "primes" the kidney to enhanced susceptibility to I-R injury via induction of mitochondrial dysfunction.
Study provides evidence supporting that rs243866/rs243865 in the MMP-2 gene might be involved with blood pressure levels in obese resistant hypertensive subjects.
Data suggest that the MMP-2 -735 CT genotype, -735 T allele and combined genotype of MMP-2-735TT + MMP-9 (显示 MMP9 抗体)-1562CC were to have protection from developing severe HIV-associated neurocognitive disorders (HAND).
study results suggest an association between matrix metalloproteinase 2, matrix metalloproteinase 9 (显示 MMP9 抗体) and tissue inhibitor of metalloproteinase 2 (显示 TIMP2 抗体) single nucleotide polymorphisms with sperm parameters, but not infertility
After a course of electroconvulsive therapy, MMP-2 levels were significantly increased in mood disorder patients, but MMP-9 (显示 MMP9 抗体) levels were significantly decreased in both mood disorder and schizophrenia patients. In mood disorder patients, there was a significant negative correlation between depressive symptoms and serum levels of MMP-2 and a positive correlation between depressive symptoms and MMP-9 (显示 MMP9 抗体).
MMP2-1306C/T and TIMP2 (显示 TIMP2 抗体)-418 G/C gene variants as risk factors for patients with relapsing remitting multiple sclerosis, was studied.
The expression of RECK (显示 RECK 抗体) in human healthy and diseased gingiva may contribute to periodontal physiological and pathological processes; low RECK (显示 RECK 抗体) expression may be associated with the enhanced MMP-2 and MMP-9 (显示 MMP9 抗体) production in inflamed gingiva.
Results continue to establish ANG (显示 ANG 抗体) as an oncoprotein and further reveal that ANG (显示 ANG 抗体) contributes to oncogenesis by the activation of MMP2 through modulation of DNMT3b (显示 DNMT3B 抗体) functions.
This study demonstrated that MMP2 higher expression in glioblastoma
GABRA3 (显示 GABRA3 抗体) induced MMP-2 and MMP-9 (显示 MMP9 抗体) expression through activation of the JNK (显示 MAPK8 抗体)/AP-1 (显示 FOSB 抗体) signaling pathway, promoting lymphatic metastasis in lung adenocarcinoma.
Kinase activation led to increased MMP-2 and MT1-MMP (显示 MMP14 抗体) expression and melanoma cell migration induced by hHK-1 (显示 HOOK1 抗体). Thus, hHK-1 (显示 HOOK1 抗体) and the NK1 receptor (显示 TACR1 抗体) are critical to melanoma cell migration and each may be a promising chemotherapeutic target
this study shows that differential FFAR1 (显示 FFAR1 抗体) signaling is associated with gene expression or gelatinase granule release in bovine neutrophils
NADPH oxidase (显示 NOX1 抗体) plays an important role in proMMP-2 expression and activation and MMP-2 mediated SMC (显示 DYM 抗体) proliferation occurs through the involvement of Spm (显示 NPC1 抗体)-Cer (显示 CBLN1 抗体)-S1P (显示 MBTPS1 抗体) signaling axis under ANG II (显示 AGT 抗体) stimulation of PASMCs
The expression patterns of MMP1 (显示 MMP1 抗体), MMP2, and MMP8 (显示 MMP8 抗体) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1 (显示 MMP1 抗体), MMP2, and MMP8 (显示 MMP8 抗体) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1 (显示 MMP1 抗体), MMP2, and MMP8 (显示 MMP8 抗体) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.
The results showed that a decrease in MMP-1 (显示 MMP1 抗体) and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.
Activation of cytosolic MMP-9 (显示 MMP9 抗体) and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
Data indicate the involvement of PKC-alpha (显示 PKCa 抗体) in proMMP-2 activation and inhibition of TIMP-2 (显示 TIMP2 抗体) expression by NF-kappaB (显示 NFKB1 抗体)-MT1-MMP (显示 MMP14 抗体)-dependent and -independent pathway.
Data suggest that EMMPRIN derived from endometrial epithelial cells regulates expression of matrix metalloproteinases (MMP-2; MMP-14 (显示 MMP14 抗体)) in endometrial stromal cells; expression of stromal MMPs is significantly higher in coculture with epithelial cells.
Adding pure bovine MMP-2 to the smooth muscle membrane suspension causes an increase in Ca(2+)-ATPase (显示 CA-P60A 抗体) activity, but the pretreatment with TIMP-2 (显示 TIMP2 抗体) inhibits the increase in the enzyme activity
A differential pattern of matrix metalloproteinase-2 and Tissue inhibitor metalloproteinase-2 was observed in cow uteri with adenomyosis.
MMP-14 (显示 MMP14 抗体), MMP-2 and TIMP-2 (显示 TIMP2 抗体) are co-localized in the fetal compartment and therefore could influence the timely release of fetal membranes in cattle.
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (显示 MMP9 抗体), TIMP1 (显示 TIMP1 抗体), and NGAL (显示 LCN2 抗体) (also MMP2 in 220 kDa complex) without proteolytic activity.
Data demonstrate for the first time that MMP2 and MMP9 (显示 MMP9 抗体) are expressed in swine ovarian follicle both in theca and granulosa layers.
FiO2 used for resuscitation affects matrix metalloproteinases MMP-9 (显示 MMP9 抗体) and MMP-2, caspase-3 (显示 CASP3 抗体) and BDNF (显示 BDNF 抗体)
MMP-2 may play an important role in regulating MLC1 turnover in the heart under normal physiological conditions
Oxygen for newborn resuscitation increases MMP-2/-9 activity resulting in tissue damage and influencing remodeling processes.
PI3K-dependent regulation of MT1-MMP (显示 MMP14 抗体) protein synthesis and subsequent activation of latent MMP-2 as critical events in neointimal hyperplasia after vascular injury.
MMP-2 processes dental sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis
contribution of MMPs to the inflammatory breakdown of the blood-CSF (显示 CSF2 抗体) barrier in vitro
The levels of matrix metalloproteinase-2 and matrix metalloproteinase-9 (显示 MMP9 抗体) in the corpus luteum of swine during luteolysis are reported.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (显示 VEGFA 抗体), pro-MMP-9 (显示 MMP9 抗体), MMP-2, VEGFR-1 (显示 FLT1 抗体), VEGFR-2 (显示 KDR 抗体), and TIMP-1 (显示 TIMP1 抗体), which may contribute to the development of venous stenosis.
Inflammatory factors such as TNF-alpha (显示 TNF 抗体) can stimulate MMP-2/9 activity in corneal epithelium cells. This may be a potential manipulating mechanism of MMP expression in the pathogenesis of corneal diseases
Results provide evidence that MMP-2 bears the potentiality to cleave alpha-DG enriched from rabbit skeletal muscle indicating that this degradation indeed might also occur in vivo.
In conclusion, MMP-2 could be responsible for the proteolysis of dystrophin (显示 DMD 抗体).
Castor (显示 CASZ1 抗体) oil polymer induces bone formation with high matrix metalloproteinase-2 expression.
MMP2 spinal cord expression is increased in cervical spondylotic myelopathy.
Ulinastatin (显示 AMBP 抗体) effectively inhibited the increased expression of MMP-2, MMP-3 (显示 MMP3 抗体), and iNOS (显示 NOS2 抗体) in degenerated NP cells induced by IL-1beta (显示 IL1B 抗体) in vitro.
Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 (显示 MMP9 抗体) and TIMP-1 (显示 TIMP1 抗体) in rabbits with acute paraquat poisoning.
The RNA interference targeting COX-2 (显示 COX2 抗体) can effectively inhibit the expression of COX-2 (显示 COX2 抗体) and MMP-2 in IL-1alpha stimulated rabbit corneal stromal cells in vitro.
Our results strongly suggest that ischaemic postconditioning may exert part of its cardioprotective effects through the inhibition of MMP-2 activity.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene.
, matrix metalloprotease 2
, matrix metalloproteinase
, matrix metalloproteinase 2
, 72 kDa type IV collagenase
, Gelatinase A
, matrix metalloproteinase-2
, 72 kDa gelatinase
, gelatinase A
, 72kD gelatinase
, 72kD type IV collagenase
, 72kDa gelatinase
, 72kDa type IV collagenase
, collagenase type IV-A
, matrix metalloproteinase-II
, neutrophil gelatinase
, matrix metalloproteinase 2 (72 KDa type IV collagenase)
, matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)