serine/arginine-Rich Splicing Factor 2 (SRSF2) ELISA试剂盒

The protein encoded by SRSF2 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. 再加上,我们可以发SRSF2 抗体 (34)SRSF2 蛋白 (7)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
SRSF2 6427 Q01130
SRSF2 20382 Q62093
SRSF2 494445 Q6PDU1
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Human serine/arginine-Rich Splicing Factor 2 (SRSF2) interaction partners

  1. The aberrantly spliced target genes and deregulated cellular pathways associated with the commonly mutated splicing factor (显示 SLU7 ELISA试剂盒) genes in myelodysplastic syndromes (SF3B1, SRSF2 and U2AF1 (显示 U2AF1 ELISA试剂盒)) are being identified, illuminating the molecular mechanisms underlying the disease. (Review)

  2. adverse prognostic impact of SRSF2 mutations on OS and AML (显示 RUNX1 ELISA试剂盒) transformation in patients with de novo MDS (显示 PAFAH1B1 ELISA试剂盒)

  3. SRSF2 mutation is associated with chronic myelomonocytic leukemia.

  4. Mutation in SRSF2 gene is associated with Uveal Melanoma.

  5. Myelodysplastic syndrome -related P95 (显示 NBN ELISA试剂盒) point mutants of SRSF2 lead to alternative splicing of CDC25C (显示 CDC25C ELISA试剂盒) in a manner that is not dependent on the DNA damage response.

  6. Findings identify SRSF2 as a key regulator of RNA splicing dysregulation in cancer, with possible clinical implications as a candidate prognostic factor in patients with HCC (显示 FAM126A ELISA试剂盒).

  7. depletion of the splicing factor (显示 SLU7 ELISA试剂盒) arginine-rich splicing factor 2 (显示 SRSF1 ELISA试剂盒) (SRSF2) leads to enhanced cytotoxicity of breast cancer cells by KM100

  8. Data suggest that RBM25 is required for the viability of multiple human cell lines, suggesting that it could play a key role in pre-mRNA splicing; a region of RBM25 spanning Lys77 binds with high affinity to SRSF2, a crucial protein in exon definition, but only when Lys77 is unmethylated. (RBM25 = RNA binding motif protein 25; SRSF2 = serine- and arginine-rich splicing factor 2 (显示 SRSF1 ELISA试剂盒))

  9. mutations in the SRSF2/ASXL1 (显示 ASXL1 ELISA试剂盒)/RUNX1 (显示 RUNX1 ELISA试剂盒) gene panel identified as significant prognostic markers in systemic mastocytosis

  10. It was found that the absence of mutations in the SRSF2, ASXL1 (显示 ASXL1 ELISA试剂盒), and/or RUNX1gene panel at baseline and a reduction of the KIT D816V allele burden more than 25% at month 6 are the most favorable predictors for improved survival in midostaurin-treated advanced systemic mastocytosis patients.

Mouse (Murine) serine/arginine-Rich Splicing Factor 2 (SRSF2) interaction partners

  1. Mice expressing Srsf2 mutation Srsf2P95H, which commonly occurs in individuals with MDS (显示 MECOM ELISA试剂盒) and AML (显示 RUNX1 ELISA试剂盒), in an inducible, hemizygous manner in hematopoietic cells rapidly succumbed to fatal bone marrow failure, demonstrating that Srsf2-mutated cells depend on the wild-type Srsf2 allele for survival.

  2. Findings have shown that SRSF2 not only is involved in splicing regulation of a large number of transcripts but also activates transcription of metabolism-related genes and transcription factors.

  3. Depletion of SRSF2 enhances reovirus replication and cytopathic effect, suggesting that T1L mu2 (显示 AP2M1 ELISA试剂盒) modulation of splicing benefits the virus.

  4. HIV-1-Tat (显示 TAT ELISA试剂盒) Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A (显示 DYRK1A ELISA试剂盒) Kinase.

  5. The findings suggest that intact SRSF2 is essential for the functional integrity of the hematopoietic system and that its mutations likely contribute to development of myelodysplastic syndromes.

  6. SRSF2 mutations alter SRSF2's normal sequence-specific RNA binding activity, thereby altering the recognition of specific exonic splicing enhancer motifs to drive recurrent mis (显示 AMH ELISA试剂盒)-splicing of key hematopoietic regulators

  7. Study reports that SRSF2 (also known as SC35, an SR-splicing factor (显示 SLU7 ELISA试剂盒)) is part of the 7SK complex assembled at gene promoters and plays a direct role in transcription pause release.

  8. Specific effects on regulated splicing by SR proteins SRSF1 (显示 SRSF1 ELISA试剂盒) and SRSF2 depends on a complex set of relationships with multiple other SR proteins in mammalian genomes.

  9. Deficiency of the splicing factor (显示 SLU7 ELISA试剂盒) Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn (显示 STMN1 ELISA试剂盒) splicing.

  10. Oct-4 distribution was examined relative to that of the unphosphorylated form of RNA polymerase II (Pol II) and splicing factor (SC 35) in the intranuclear entities such as perichromatin fibrils.

SRSF2 抗原简介

Antigen Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11.

Gene names and symbols associated with SRSF2

  • serine and arginine rich splicing factor 2 (SRSF2) 抗体
  • serine/arginine-rich splicing factor 2 (Srsf2) 抗体
  • serine and arginine rich splicing factor 2 (Srsf2) 抗体
  • serine/arginine-rich splicing factor 2 L homeolog (srsf2.L) 抗体
  • D11Wsu175e 抗体
  • MRF-1 抗体
  • pr264 抗体
  • sc-35 抗体
  • sc35 抗体
  • sfrs2 抗体
  • sfrs2a 抗体
  • Sfrs10 抗体
  • srp30b 抗体

Protein level used designations for SRSF2

SR splicing factor 2 , splicing component, 35 kDa , splicing factor SC35 , splicing factor, arginine/serine-rich 2 , myelin regulatory factor 1 , putative myelin regulatory factor 1 , splicing factor Sc35 , splicing factor, arginine/serine-rich 2 (SC-35) , SC-35 , PR 264 protein , arginine/serine-rich2 splicing factor

6427 Homo sapiens
20382 Mus musculus
494445 Rattus norvegicus
508312 Bos taurus
396195 Gallus gallus
768117 Sus scrofa
380435 Xenopus laevis
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