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Involved in proliferation and apoptosis in myeloid precursor cells (By similarity). 再加上，我们可以发Yippee-Like 3 (Drosophila) 蛋白 (4)和数多这个蛋白质的别的产品。
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Studies with mouse YPEL3, originally named small unstable apoptot (显示 ARHGAP24 抗体)ic prote (显示 CKAP4 抗体)in (SUAP), confirmed th (显示 TP53 抗体)at the gene encodes a growth suppressive highly unstable protein.[review]
Data show that YPEL3 is downregulated in nasopharyngeal carcinoma (NPC (显示 NPC1 抗体)) cell lines and tissue samples and it suppresses NPC (显示 NPC1 抗体) EMT (显示 ITK 抗体) and metastasis by suppressing the Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling pathway.
YPEL3 expression, which is induced by the removal of estrogen or treatment with tamoxifen triggers cellular senescence in MCF-7 cells while loss of YPEL3 increases the growth rate of MCF-7 cells.
YPEL3 is downregulated in colon tumors.
In this review we show that transcriptionally active forms of p73 (显示 TP73 抗体) and p63 (显示 RPE65 抗体), family members of p53 (显示 TP53 抗体), can transactivate the human YPEL3 gene[review]
Findings point to YPEL3 being a novel tumor suppressor, which upon induction triggers a permanent growth arrest in human tumor and normal cells.
Involved in proliferation and apoptosis in myeloid precursor cells (By similarity).
protein yippee-like 3
, small ubiquitinated apoptotic protein
, yippee-like 3