anti-Wntless Homolog (Drosophila) (WLS) 抗体

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. 再加上,我们可以发WLS 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
WLS 79971 Q5T9L3
WLS 68151 Q6DID7
WLS 362065 Q6P689
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Showing 10 out of 19 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 IHC, WB Human Muscle 100 μL Log in to see 2至3个工作日
Cow 非结合性 WB WB Suggested Anti-GPR177 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human Liver Host:  Rabbit  Target Name:  WLS  Sample Tissue:  Human THP-1 Whole Cell  Antibody Dilution:  1ug/ml 100 μL Log in to see 2至3个工作日
Cow 非结合性 IHC, IHC (p), WB Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11至14个工作日
非结合性 ELISA, WB 100 μL Log in to see 2至3个工作日
非结合性 IHC, ELISA, WB 100 μL Log in to see 2至3个工作日
非结合性 WB GPR177 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 9至11个工作日
非结合性 IHC, WB GPR177 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Skeletal muscle cells (arrows) in Human Muscle. Magnification is at 400X GPR177 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X 50 μg Log in to see 9至11个工作日
非结合性 ICC, IF, IHC (p), WB Immunohistochemistry-Paraffin: GPR177/WLS Antibody  - Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in cytotrophoblastic cells. Immunocytochemistry/Immunofluorescence: GPR177/WLS Antibody  - Staining of human cell line AF22 shows localization to endoplasmic reticulum. 100 μL Log in to see 10至13个工作日
小鸡 非结合性 ICC, IHC, WB Western Blot analysis of WLS polyclonal antibody (1:2000) on HEK293 cell transfected with WLS-GFP. The 293 cell protein lysate contains both transfected WLS-GFP fusion protein (75KDa) and endogenous WLS protein (~55KDa). 100 μL Log in to see 11至12个工作日
小鸡 非结合性 WB   0.1 mL Log in to see 2至3个工作日


Human Wntless Homolog (Drosophila) (WLS) interaction partners

  1. GPR177 as a novel candidate for prognostic marker as well as a promising target for treatment of gastric cancer patients.

  2. Wls is differentially expressed in Intrahepatic Cholangiocarcinoma tissues and positively related to tumor stage and lymphatic invasion.

  3. This study provides a brand new evidence that GOLPH3 promotes glioma cell proliferation by facilitating Wls recycling and Wnt/beta-catenin signaling.

  4. These data showed that Wls was differentially expressed in HCC. Statistical analysis results suggest that Wls expression might increase as HCC progresses.

  5. Wls-SEC12 binding is stable, with the interacting interface biochemically mapped to cytosolic segments of individual proteins. Mutant Wls that fails to communicate with the COPII machinery cannot effectively support Wnt secretion. These data suggest that formation of early Wnt secretory vesicles is carefully regulated to ensure proper export of functional ligands

  6. we identified novel associations in WLS , ARHGAP1 , and 5' of MEF2C ( P- values < 8x10 - 5 ; false discovery rate (FDR) q-values < 0.01) that were much more strongly associated with BMD compared to the GWAS SNPs.

  7. Our data suggest that Wls protein is related to tumor metastasis and advanced TNM stage, and may be used as a new marker for prognosis of gastric carcinoma.

  8. These results indicate that WLS may play a role in invasion and metastasis of colorectal carcinoma.

  9. Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress.

  10. Genetic variation at the WLS and CCDC170/ESR1 loci were found to be significantly associated with bone mineral density

  11. This study has revealed a strong association between the expression of WLS and HER2 that has important biological and clinical implications.

  12. This study identified CMTM8 as a new candidate tumor suppressor gene and GPR177 as a new candidate oncogene in osteosarcoma.

  13. GPR177 played an essential role in disease relapse and poor survival in patients with B-cell precursor acute lymphoblastic leukemia.

  14. endogenous WLS binds Wnts in the endoplasmic reticulum, cycles to the plasma membrane, and then returns to the endoplasmic reticulum through the Golgi.

  15. Colorectal tumors express elevated levels of Wnt3 and GPR177.

  16. The data suggest that the common variants of WLS analyzed in this study are not associated with opioid or cocaine addiction.

  17. Evi expression in psoriatic skin biopsies is down-regulated, suggesting that Evi-deficient mice developed skin lesions that resemble human psoriasis.

  18. findings lead to a proposed mechanism by which Gpr177 controls skeletal development through modulation of autocrine and paracrine Wnt signals in a lineage-specific fashion

  19. WLS functions as a negative regulator of melanoma proliferation and spontaneous metastasis by activating WNT/beta-catenin signalling.

  20. The Evi/Wls overexpression is sufficient to promote downstream Wnt signalling.

Mouse (Murine) Wntless Homolog (Drosophila) (WLS) interaction partners

  1. Data show that Shh-Cre-mediated deletion of Wntless, the Wnt cargo protein, in mouse posterior limb mesenchyme causes bone syndactyly of the 3rd and 4th digits, resembling the human Malik-Percin type . Wntless(Shh-Cre) limbs displayed altered expression of hedgehog pathway genes and impaired noncanonical Wnt signaling activity.

  2. WLS role in the principal cells of the caput epididymidis during sperm maturation

  3. Wntless-deficient macrophages presented a unique subset of M2-like macrophages with anti-inflammatory, reparative, and angiogenic properties. Serial echocardiography studies revealed that mice lacking macrophage Wnt secretion showed improved function and less remodeling 30 days after myocardial infarction.

  4. GPR177 in Sertoli cells had no apparent influence on spermatogenesis, whereas loss of GPR177 in germ cells disrupted spermatogenesis in an age-dependent manner.

  5. these results suggest that Gpr177 controls epithelial initiation of the fungiform placode through signaling via epithelial Wnt ligands.

  6. regulates chondrogenesis and osteogenesis through both canonical and noncanonical Wnt signaling

  7. Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than hematopoietic stem cells maintenance.

  8. Wls-mediated secretion of Wnt ligands from the developing ventral body wall mesenchyme plays a critical role in fusion of the sternum and closure of the secondary body wall.

  9. eletion of the Wls gene in odontoblasts appears to reduce canonical Wnt activity, leading to inhibition of odontoblast maturation and root elongation.

  10. The existence of spatial compartmentation in the rhombic lip and the interplay between Wls, Math1, and Pax6 in the rhombic lip provides novel views of early cerebellar development.

  11. Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium

  12. The loss of Wls in the ventral epithelium, which blocks the secretion of Wnt proteins, resulted in dysgenesis of ventral musculature and genitourinary tract during embryonic development.

  13. Gpr177 regulates pulmonary vasculature development.

  14. Evi expression in psoriatic skin biopsies is down-regulated, suggesting that Evi-deficient mice developed skin lesions that resemble human psoriasis.

  15. Wnt production mediated by Gpr177 is essential for mammary morphogenesis.

  16. Wntless is necessary for respiratory epithelial cell differentiation.

  17. Here we report that Wnt production mediated by Gpr177, the mouse Wls ortholog, is essential for hair follicle induction.

  18. Wls may regulate hair follicle induction by mediating the Wnt/beta-catenin pathway.

  19. Wls-deficient osteoblasts had a defect in differentiation and mineralization, with significant reductions in the expression of key osteoblast differentiation regulators.

  20. Wntless plays a role in signaling regulation during the formation of cancer in addition to its role as a retromer protein in mammalian systems.

Zebrafish Wntless Homolog (Drosophila) (WLS) interaction partners

  1. the chaperon Wls and its ligands Wnt9a and Wnt5b are expressed in the ectoderm, whereas juxtaposed chondrocytes express Frzb and Gpc4.

  2. disruption of wls resulted in a significant loss of craniofacial bone, whereas lack of gpc4, wnt5b and wnt9a resulted in severely delayed endochondral ossification.

  3. Homozygous wls mutants show a reduction in two cell populations that contribute to the presumptive dorsal habenulae.

  4. The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt secretion in a variety of embryonic and adult tissue types.

Fruit Fly (Drosophila melanogaster) Wntless Homolog (Drosophila) (WLS) interaction partners

  1. Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress.

  2. The uncharacterized Drosophila protein Evi5 was identified as an essential membrane trafficking regulator, and the molecular mechanism by which Evi5 regulates BC migration was described.

  3. Syx1A, Rab11, and its effector Myosin5 were required for proper Evi vesicle release.

  4. DSNX3 regulates Wg secretion via retromer-dependent Wls recycling

  5. Por-mediated lipidation of the S239-equivalent residue is essential for the interaction with, and secretion by, Wls.

  6. we propose that Wntless represents an ancient partner for Wnts dedicated to promoting their secretion into the extracellular milieu.

  7. The function of Srt is restricted to events occurring within the Wg-producing cells, study shows that srt is not required for any aspect of Hedgehog (Hh) signal transduction, suggesting specificity of srt for the Wg pathway.

  8. Recent studies have identified Wntless (Wls) and the retromer complex as essential components involved in Wnt signaling.

  9. Wg, clathrin-mediated endocytosis and retromer sustain a Wls traffic loop from the Golgi to the plasma membrane and back to the Golgi, thereby enabling Wls to direct Wnt secretion.

  10. WntD, a recently characterized Drosophila Wnt family member, does not require Porcupine or Wntless/Evi/Sprinter for its secretion or signaling activity

  11. These findings uncover a previously unknown cellular mechanism by which a secreted Wnt is transported across synapses by Evi-containing vesicles and reveal trafficking functions of Evi in both the Wnt-producing and the Wnt-receiving cells.

WLS 抗原简介


Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

Gene names and symbols associated with WLS

  • wntless Wnt ligand secretion mediator (WLS) 抗体
  • wntless homolog (Drosophila) (Wls) 抗体
  • wntless Wnt ligand secretion mediator (Wls) 抗体
  • wntless Wnt ligand secretion mediator (wls) 抗体
  • wntless (wls) 抗体
  • 5031439A09Rik 抗体
  • AI173978 抗体
  • AI987742 抗体
  • C1orf139 抗体
  • CG6210 抗体
  • Dmel\\CG6210 抗体
  • evi 抗体
  • Evi/Wls 抗体
  • gpr117 抗体
  • gpr177 抗体
  • mig-14 抗体
  • MRP 抗体
  • sb:cb610 抗体
  • srt 抗体
  • Wls 抗体
  • wls/evi 抗体
  • wu:fb36d04 抗体
  • wu:fb44d10 抗体
  • wu:fb50c06 抗体
  • zgc:64091 抗体

Protein level used designations for WLS

G protein-coupled receptor 177 , integral membrane protein GPR177 , protein evenness interrupted homolog , protein wntless homolog , putative NF-kappa-B-activating protein 373 , putative NFkB activating protein 373 , EVI , CG6210-PA , CG6210-PB , evenness interrupted , sprinter , wls-PA , wls-PB

79971 Homo sapiens
68151 Mus musculus
362065 Rattus norvegicus
406420 Danio rerio
424707 Gallus gallus
528123 Bos taurus
39259 Drosophila melanogaster
611491 Canis lupus familiaris
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