WTIP 蛋白

蛋白简介

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator that represses WT1- dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.

Gene names and symbols associated with WTIP

• WT1 interacting protein (Wtip) 抗体
• WT1 interacting protein (WTIP) 抗体
• WT1 interacting protein (wtip) 抗体
• Wilms tumor 1 interacting protein (WTIP) 抗体
• WT1 interacting protein L homeolog (wtip.L) 抗体
• 显示所有的基因名称
• WT1-interacting protein (Wtip) 抗体

• RGD1306411 抗体
• si:ch211-79l17.3 抗体

Protein level used designations for WTIP

WT1-interacting protein , Wilms tumor protein 1-interacting protein , Wilms tumor protein 1-interacting protein homolog , WT1-interacting protein homolog , Wilms tumor 1 interacting protein , xWtip