This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008].
Vuolo, Stevenson, Heesom, Stephens: "Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function." in: eLife, Vol. 7, (2019) (PubMed).
Yamamoto, Kasamatsu, Okubo, Nakashima, Fushimi, Minakawa, Kasama, Shiiba, Tanzawa, Uzawa: "Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer." in: Biochemical and biophysical research communications, Vol. 495, Issue 4, pp. 2469-2474, (2018) (PubMed).
Taylor, Dantas, Duran, Wu, Lachman, Nelson, Cohn, Vallee, Krakow: "Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome." in: Nature communications, Vol. 6, pp. 7092, (2015) (PubMed).
Asante, Stevenson, Stephens: "Subunit composition of the human cytoplasmic dynein-2 complex." in: Journal of cell science, (2014) (PubMed).
Asante, Maccarthy-Morrogh, Townley, Weiss, Katayama, Palmer, Suzuki, Westlake, Stephens: "A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2." in: Journal of cell science, Vol. 126, Issue Pt 22, pp. 5189-97, (2013) (PubMed).