anti-Ubiquitin Specific Peptidase 8 (USP8) 抗体

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. 再加上,我们可以发USP8 试剂盒 (9)USP8 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
USP8 9101 P40818
USP8 296121  
USP8 84092 Q80U87
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Showing 10 out of 90 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-USP8 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: HCT15 cell lysate USP8 is supported by BioGPS gene expression data to be expressed in HCT15 100 μL 2至3个工作日
$289.00
详细
Cow 非结合性 IHC, WB WB Suggested Anti-USP8 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate WB Suggested Anti-USP8  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control:.93T cell lysate  USP8 is supported by BioGPS gene expression data to be expressed in HEK293T 100 μL 2至3个工作日
$319.00
详细
非结合性 WB 100 μg 2至3个工作日
$265.00
详细
非结合性 ICC, IF, IP, IHC (p), WB ICC/IF Image USP8 antibody detects USP8 protein at cytoplasm by immunofluorescent analysis. Sample: A549 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: USP8 protein stained by USP8 antibody , diluted at 1:500. Blue: Hoechst 33342 staining. WB Image Sample (30 ug of whole cell lysate) A: H1299 B: HCT116 5% SDS PAGE antibody diluted at 1:5000 100 μL 3至4个工作日
$466.18
详细
非结合性 EIA, IHC (p), WB 0.4 mL 6至8个工作日
$484.00
详细
非结合性 EIA, WB 0.4 mL 6至8个工作日
$484.00
详细
Cow 非结合性 WB 100 μL 11至14个工作日
$551.83
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小鸡 非结合性 WB 100 μL 11至14个工作日
$581.17
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非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13至16个工作日
$350.00
详细
非结合性 IHC (p), WB Western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the USP8 antibody detected the USP8 protein (arrow). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma; HC = hepatocarcinoma. 400 μL 2至3个工作日
$515.63
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引用最多的anti-USP8 抗体

  1. Human Polyclonal USP8 Primary Antibody for ELISA, WB - ABIN545113 : Nomura, Nagase, Miyajima, Sazuka, Tanaka, Sato, Seki, Kawarabayasi, Ishikawa, Tabata: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. in DNA research : an international journal for rapid publication of reports on genes and genomes 1995 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal USP8 Primary Antibody for IHC (p), ELISA - ABIN545114 : Naviglio, Mattecucci, Matoskova, Nagase, Nomura, Di Fiore, Draetta: UBPY: a growth-regulated human ubiquitin isopeptidase. in The EMBO journal 1998 (PubMed)
    Show all 3 Pubmed References

更多抗USP8的相互作用对抗体

Human Ubiquitin Specific Peptidase 8 (USP8) interaction partners

  1. we identify USP8 as a key enzyme that regulates SHANK3 protein levels in neurons

  2. Deubiquitination of EPG5 by USP8 guards the autophagic flux in embryonic stem cells (ESCs) to maintain their stemness. This work uncovers a novel crosstalk pathway between ubiquitination and autophagy through USP8-EPG5 interaction to regulate the stemness of ESCs.

  3. USP8 interacted with transforming growth factorbetaactivated kinase1 (TAK1) and deubiquitinated the K63linked ubiquitination of TAK1.

  4. SFN enhances RTK stabilization through abnormal USP8 regulation in lung adenocarcinoma

  5. Biophysical and structural insight into the USP8/14-3-3 interaction.

  6. High USP8 expression is associated with breast neoplasms.

  7. High expression of USP8 was correlated with advanced tumor stage and high recurrence risk. Moreover, USP8 was identified as a novel independent prognostic factor for CSCC patients.

  8. In summary, we show that, contrary to the pituitary ACTH-secreting tumors, the USP8 hotspot sequence on exon 14 is not mutated in tumors causing ectopic ACTH secretion syndrome (EAS). Although USP8 is expressed in all EAS tumors examined, our in vitro data indicate that it is not involved in the regulation of ectopic proopiomelanocortin transcription.

  9. USP8 deubiquitinates Sec31A and inhibits the formation of large COPII carriers, thereby suppressing collagen IV secretion.

  10. review: role of USP8 driver mutations in Cushing's Disease

  11. Data (including data from studies using knockout and transgenic mice/cells) suggest that CLEC16A, NRDP1, and USP8 form tripartite complex; CLEC16A-NRDP1-USP8 complex appears to rely on ubiquitin signals to promote mitophagy and maintain mitochondrial function necessary for beta-cell function. (CLEC16A = C-type lectin domain family 16 member A; NRDP1 = ubiquitin-protein ligase NRDP1; USP8 = ubiquitin specific peptidase 8)

  12. the EGFR-USP8-trichoplein-Aurora A axis is a critical signaling cascade that restricts ciliogenesis in dividing cells, and functions to facilitate cell proliferation

  13. in human cells, Usp8 knockdown increased the lysosomal degradation of alpha-synuclein.

  14. Overexpression of USP8 in lung adenocarcinoma is an early event during the course of tumor progression, and is related to EGFR expression.

  15. Somatic mutations in USP8 are common in Nelson's tumors, and are associated with less favorable outcome after surgery.

  16. Data indicate that USP8 functions as a novel deubiquitylase of FLIPL and inhibits extrinsic apoptosis by stabilizing FLIPL.

  17. Somatic USP8 gene mutations are a common cause of pediatric Cushing disease due to pituitary adenoma.

  18. findings demonstrate that USP8 plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501.

  19. USP8 regulates VEGFR2 trafficking, signaling and proteolysis.

  20. Ubpy loss of function results in the accumulation of autophagosomes due to a blockade of the autophagy flux.

Mouse (Murine) Ubiquitin Specific Peptidase 8 (USP8) interaction partners

  1. Deubiquitination of EPG5 by USP8 guards the autophagic flux in embryonic stem cells (ESCs) to maintain their stemness. This work uncovers a novel crosstalk pathway between ubiquitination and autophagy through USP8-EPG5 interaction to regulate the stemness of ESCs.

  2. USP8 interacted with transforming growth factorbetaactivated kinase1 (TAK1) and deubiquitinated the K63linked ubiquitination of TAK1.

  3. UBPy-sorted cargo to acrosome biogenesis and effects of its derailment in a mouse model of globozoospermia, the infertile Vps54 (L967Q) mutant, are reported.

  4. the membrane receptor MET, described herein for the first time in spermatids, is a USP8/UBPy-target substrate is delivered to the acrosome.

  5. in neuronal cells USP8 could be involved in endosomal trafficking, retrograde transport and synaptic plasticity. In disorders leading to neurodegeneration USP8 is upregulated and could influence the neuron-oligodendrocyte interactions.

  6. The spatio-temporal expression of mUBPy suggests that the enzyme may be involved in neuroregulatory processes during embryogenesis.

  7. a role for the USP8.STAM complex as a protective mechanism regulating early endosomal sorting of EGFR between pathways destined for lysosomal degradation and recycling.

  8. USP8 was able to interact with spermatid endosomal-sorting complex required for transport-0 and microtubule structures; USP8 can directly link, via its MIT domain, the labeled vesicles/developing acrosome to microtubules.

  9. in wobbler testis expression of mouse ubiquitin-specific processing protease (mUBPy)is up-regulated, while a differential sorting of the protein characterizes wobbler spermatids where acrosome formation is impaired

  10. Data indicate a novel mechanism where diacylglycerol kinase delta and protein kinase Calpha modulate the levels of ubiquitinated epidermal growth factor receptors through Akt and ubiquitin-specific protease 8.

  11. deubiquitinating enzyme specifically expressed in testis, associates with the acrosome and centrosome in mouse germ cells

  12. Results indicate that Nrdp1 is a specific target for the USP8 deubiquitinating enzyme and are consistent with a model where USP8 augments Nrdp1 activity by mediating its stabilization.

  13. We conclude that UBPY negatively regulates the rate of EGFR down-regulation by deubiquitinating EGFR on endosomes.

  14. UBPY-mediated EGFR de-ubiquitination promotes EGFR degradation

  15. UBPy may play a key role during mouse fertilization as a novel centrosomal component.

  16. These results unveil a central and nonredundant role of UBPy in growth regulation, endosomal sorting, and the control of receptor tyrosine kinases in vivo.

  17. UBPY is catalytically inhibited in a phosphorylation-dependent manner by 14-3-3s during the interphase, and this regulation is cancelled in the M phase.

  18. Moderate expression of mouse UBPy was found in the amygdaloid complex, supraoptic nucleus, arcuate and ventromedial nuclei of hypothalamus, lateral hypothalamic area and lateral and reticular part of the substantia nigra.

USP8 抗原简介

蛋白简介

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.

Gene names and symbols associated with USP8

  • ubiquitin carboxyl-terminal hydrolase 8 (LOC9310109) 抗体
  • ubiquitin carboxyl-terminal hydrolase 8 (MGYG_00369) 抗体
  • ubiquitin specific peptidase 8 (USP8) 抗体
  • ubiquitin specific peptidase 8 (Usp8) 抗体
  • AI574262 抗体
  • AW557536 抗体
  • HumORF8 抗体
  • mKIAA0055 抗体
  • Ubpy 抗体

Protein level used designations for USP8

ubiquitin carboxyl-terminal hydrolase 8 , ubiquitin-specific-processing protease 8 , ubiquitin specific peptidase 8 , ubiquitin carboxyl-terminal hydrolase 8-like , deubiquitinating enzyme 8 , hUBPy , ubiquitin isopeptidase Y , ubiquitin specific protease 8 , ubiquitin thioesterase 8 , ubiquitin thiolesterase 8 , putative deubiquitinating enzyme

GENE ID SPECIES
9310109 Arabidopsis lyrata subsp. lyrata
10031598 Arthroderma gypseum CBS 118893
100408559 Callithrix jacchus
100437819 Pongo abelii
9101 Homo sapiens
296121 Rattus norvegicus
84092 Mus musculus
100157546 Sus scrofa
415451 Gallus gallus
100351436 Oryctolagus cuniculus
100720255 Cavia porcellus
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