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USP21 encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. 再加上，我们可以发USP21 蛋白 (4)和数多这个蛋白质的别的产品。
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Human Polyclonal USP21 Primary Antibody for IHC (p), WB - ABIN387919
Puente, Sánchez, Overall, López-Otín: Human and mouse proteases: a comparative genomic approach. in Nature reviews. Genetics 2003
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Cow (Bovine) Polyclonal USP21 Primary Antibody for ELISA - ABIN451708
Gong, Kamitani, Millas, Yeh: Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins. in The Journal of biological chemistry 2000
Data show that ubiquitin variants (Ubvs) that bind to USP2 (显示 USP2 抗体) or USP21 contain a similar core functional epitope, or "hot spot," consisting mainly of positions that are conserved as the wild type sequence, but also some positions that prefer mutant sequences.
USP21 binds to the promoter region of IL-8 (显示 IL8 抗体) and mediates transcriptional initiation, which regulates the stem-cell like property of human renal cell carcinoma (显示 MOK 抗体)
USP21 interacts with, deubiquitinates and stabilizes BRCA2 (显示 BRCA2 抗体) to promote efficient RAD51 (显示 RAD51 抗体) loading at DNA double-strand breaks.
a critical role of p38 (显示 CRK 抗体)-mediated USP21 phosphorylation in regulating STING-mediated antiviral functions and identifies p38 (显示 CRK 抗体)-USP21 axis as an important pathway that DNA virus adopts to avoid innate immunity responses.
USP21 recruits and stabilises Gli1 (显示 GLI1 抗体) at the centrosome.
USP21 specifically regulates the Lys48-linked polyubiquitination and stability of NANOG
Data show that SUMOylated BANP (显示 BANP 抗体), E5R, and Nac1 (显示 NACC1 抗体) (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1 (显示 NKX2-1 抗体)-interacting protein 5 (显示 CAPS 抗体) (Tip5 (显示 BAZ2A 抗体))via association with ubiquitin specific protease 21 (USP21) debiquitinase
The protein stability of IL-33 (显示 IL33 抗体) is maintained by USP21 through deubiquitination
Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3 (显示 GATA3 抗体)
Study observed a reduction in the number of A549 cells developing a primary cilium upon serum starvation when USP21 was depleted with two independent siRNA oligos.
Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation
Overexpression of USP21 inhibited RNA virus-induced RIG-I (显示 DDX58 抗体) polyubiquitination and RIG-I (显示 DDX58 抗体)-mediated interferon (显示 IFNA 抗体) signaling, while USP21 deletion resulted in elevated RIG-I (显示 DDX58 抗体) polyubiquitination, IRF3 (显示 IRF3 抗体) phosphorylation, IFN production, and antiviral responses.
USP21 plays an important role in the down-regulation of TNFalpha (显示 TNF 抗体)-induced NF-kappaB (显示 NFKB1 抗体) activation through deubiquitinating RIP1 (显示 RALBP1 抗体).
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described.
ubiquitin specific peptidase 21
, Ubiquitin specific peptidase 21
, NEDD8-specific protease
, deubiquitinating enzyme 21
, ubiquitin carboxyl-terminal hydrolase 21
, ubiquitin specific protease 21
, ubiquitin thioesterase 21
, ubiquitin thiolesterase 21
, ubiquitin-specific processing protease 21
, ubiquitin-specific protease 16
, ubiquitin-specific-processing protease 21
, ubiquitin specific protease 23
, ubiquitin-specific protease 21