anti-Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) 抗体

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. 再加上,我们可以发UCHL5 蛋白 (18)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
UCHL5 56207 Q9WUP7
UCHL5 51377 Q9Y5K5
UCHL5 360853  
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antibodies-online.cn销售最多的anti-UCHL5 抗体

Showing 10 out of 103 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-UCHL5 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Small Intestine WB Suggested Anti-UCHL5 Antibody  Positive Control: Lane 1:341 µg Zebrafish skin lysate Primary Antibody Dilution: 1:0000Secondary Antibody: Anti-rabbit-HRP Secondry  Antibody Dilution: 1:0000Submitted by: William Tse 100 μL 2至3个工作日
Cow 非结合性 WB WB Suggested Anti-UCHL5  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: HepG2 cell lysate Host: Rabbit  Target Name: UCHL5  Sample Tissue: Human Fetal Muscle  Antibody Dilution: 1.0 µg/mL 100 μL 2至3个工作日
非结合性 EIA, IHC (p), WB 0.4 mL 6至8个工作日
Bat 非结合性 WB 100 μL 11至14个工作日
Bat 非结合性 WB 100 μL 11至14个工作日
Cow 非结合性 WB 100 μL 11至14个工作日
非结合性 ELISA, WB Western blot analysis UCHL5 using HeLa whole cell lysates 100 μL 11至12个工作日
非结合性 IHC (p), WB Antibody is used in Western blot to detect UCHL5 in mouse kidney tissue lysate. HE staining of frozen human ovarian cancer tissue reacted with the primary antibody at a 1:250 dilution. Levels using the antibody on frozen tissue array (A )correlated well with the mRNA expression levels detected by Agilent expression microarray (B). 60X magnification. Data courtesy of Marlena Fejzo, University of California, Los Angeles. 400 μL 2至3个工作日
非结合性 ICC, IHC, WB 100 μL 13至16个工作日
小鼠 非结合性 ICC, IHC, WB 100 μL 13至16个工作日

引用最多的anti-UCHL5 抗体

  1. Human Polyclonal UCHL5 Primary Antibody for IHC (fro), ELISA - ABIN544864 : Lai, Chou, Chang, Liu, Lin: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. in Genome research 2000 (PubMed)
    Show all 3 Pubmed References


Mouse (Murine) Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) interaction partners

  1. PI3K-dependent UCHL5 is required for high glucose-induced TGF-betaR1 protein expression in mesangial cells. UCHL5 is also required for high glucose-induced TGF-betaR1 protein deubiquitination, p21(WAF1) and fibronectin protein expression and cell hypertrophy.

  2. ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 to activate ATP hydrolysis and enhance their own destruction

  3. this is the first report characterizing the physiological roles of Uch37 and Rpn13 in murine development and implicating a non-ATPase proteasomal protein, Rpn13, in the process of gametogenesis

Human Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) interaction partners

  1. UCH37 maintains the homeostasis of proteasomal degradation reciprocally by assisting the recruitment of the ubiquitin receptor Rpn13 into the proteasome and by reversing ubiquitination of certain critical substrates of the 26 S proteasome.

  2. Rpn13-Rpn2 complex structural analysis shows that RA190 targets hRpn13 and Uch37 through parallel mechanisms and at proteasomes, RA190-inactivated Uch37 cannot disassemble hRpn13-bound ubiquitin chains

  3. Our study provides a new mechanism for chromatin occupancy of Tcf7 and uncovers the physiological significance of Uch37 during early vertebrate development by regulating the Wnt/beta-catenin pathway.

  4. Our studies provide a molecular mechanism by which UCHL5 mitigates TGFbeta-1 signaling by stabilizing Smad2/Smad3. These data indicate that UCHL5 may contribute to the pathogenesis of idiopathic pulmonary fibrosis and may be a potential therapeutic target.

  5. Positive cytoplasmic UCHL5 tumor immunoexpression is linked to increased survival of patients with small (<5 cm) tumors (p = 0.001), disease stages I-II (p = 0.025), and age 66 years or older (p = 0.037). UCHL5 is thus a potential marker in gastric cancer with new prognostic relevance.

  6. our report demonstrates significant value in targeting USP14/UCHL5 with VLX1570 in drug-resistant Waldenstrom macroglobulinemia (WM) and carries a high potential for clinical translation

  7. UCHL5 is a promising novel prognostic marker in lymph-node-positive rectal cancer. Our results also advance the currently limited knowledge of biomarkers in colorectal cancer treatment.

  8. UCHL5 expression could function as a prognostic marker in pancreatic ductal adenocarcinoma, particularly at disease stages IIB to III. As UCHL5 is one of the few markers predicting increased survival, our results may be of clinical relevance.

  9. this work implicates hRpn13 and Uch37 in cell cycle progression, providing a rationale for their function in cellular proliferation and for the apoptotic effect of the hRpn13-targeting molecule RA190.

  10. These results uncover a novel mechanism for E2F1 transcriptional activation through removal of its Lys-63-linked ubiquitination by UCH37.

  11. Uch37 consists of two domains, a globular UCH-domain and a fibrous C-terminal tail. The C-terminal residues of Uch37 are implicated in Rpn13 binding.

  12. Data show that DEUBAD domain in RPN13 (ADRM1) activates ubiquitin thioesterase L5 (UCH-L5), and the related DEUBAD domain in INO80G (NFRKB) inhibits UCH-L5.

  13. Data indicate that ubiquitin thioesterase L5 UCH37 (UCHL5) comprises a catalytic UCH domain followed by the four-helix (alpha8-alpha11) C-terminal domain.

  14. High expression of UCH37 is significantly associated with epithelial ovarian cancer.

  15. b-AP15 is an inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.

  16. UCH37 over-expression is associated with hepatocellular carcinoma recurrence.

  17. UCH37 is associated with outcome and recurrence of ESCC and can be a novel predictor for poor prognosis of esophageal squamous cell carcinoma patients after curative resection.

  18. a functional proteomic analysis was performed to screen UCH37-interacting proteins in hepatocellular carcinoma (HCC), and glucose-regulated protein 78 was identified as one interacting with UCH37

  19. our structures reveal conformationally dynamic parts of the enzyme that may play a role in the structural transition to the more active form.

  20. Silencing of UCH37 in A549 cells induced apoptosis.

Cow (Bovine) Ubiquitin Carboxyl-terminal Hydrolase L5 (UCHL5) interaction partners

  1. Neither Uch37 alone nor the Uch37-Adrm1 or Uch37-Adrm1-S1 complexes can hydrolyse di-ubiquitin efficiently; rather, incorporation into the 19S complex is required to enable processing of polyubiquitin chains.

UCHL5 抗原简介


Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex\; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity).

Gene names and symbols associated with UCHL5

  • ubiquitin carboxyl-terminal hydrolase L5 (uchl5) 抗体
  • ubiquitin C-terminal hydrolase L5 (UCHL5) 抗体
  • ubiquitin C-terminal hydrolase L5 L homeolog (uchl5.L) 抗体
  • ubiquitin C-terminal hydrolase L5 (uchl5) 抗体
  • ubiquitin carboxyl-terminal esterase L5 (Uchl5) 抗体
  • ubiquitin C-terminal hydrolase L5 (Uchl5) 抗体
  • 5830413B11Rik 抗体
  • CGI-70 抗体
  • DKFZp459M0513 抗体
  • INO80R 抗体
  • UCH-L5 抗体
  • UCH37 抗体
  • wu:fj17f09 抗体
  • zgc:85615 抗体

Protein level used designations for UCHL5

ubiquitin carboxyl-terminal hydrolase isozyme L5 , ubiquitin carboxyl-terminal hydrolase L5 , UCH-L5 , ubiquitin C-terminal hydrolase 37 , ubiquitin C-terminal hydrolase UCH37 , ubiquitin thioesterase L5 , INO80 complex subunit R , ubiquitin carboxyl-terminal esterase L5

406357 Danio rerio
424359 Gallus gallus
457596 Pan troglodytes
478958 Canis lupus familiaris
733154 Xenopus laevis
100124308 Xenopus (Silurana) tropicalis
100174635 Pongo abelii
100195039 Salmo salar
100349016 Oryctolagus cuniculus
56207 Mus musculus
51377 Homo sapiens
360853 Rattus norvegicus
282110 Bos taurus
100144472 Sus scrofa
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