anti-UL16 Binding Protein 2 (ULBP2) 抗体

Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. 再加上,我们可以发ULBP2 试剂盒 (14)ULBP2 蛋白 (14)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
ULBP2 80328 Q9BZM5
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Showing 10 out of 46 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 WB Western blot analysis of ULBP2 expression in mouse ovary (A), rat ovary (B) whole cell lysates. 200 μL 13至14个工作日
非结合性 IHC (p), ELISA Immunochemical staining of human ULBP2 in human renal-carcinoma with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixtur 100 μL 14至16个工作日
非结合性 WB Western Blot at 1:1000 dilution Lane 1: HT-1080 whole cell lysate Lane 2: U-251 MG whole cell lysate Lysates/proteins at 20 ug per lane. Western blot analysis of ULBP2 using rabbit polyclonal ULBP2 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ULBP2 gene. 400 μL 2至3个工作日
非结合性 IHC (p) Immunochemical staining of human ULBP2 in human gastric cancer with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Immunochemical staining of human ULBP2 in human hepatoma with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). 100 μL 14至16个工作日
非结合性 ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μL 13至16个工作日
非结合性 IF, WB Immunofluorescence analysis of U2OS cells using ULBP2 antibody (ABIN6293785) at dilution of 1:100. Blue: DAPI for nuclear staining. 50 μL 11至13个工作日
非结合性 WB 100 μL 14至16个工作日
小鼠 非结合性 WB Western blot analysis of extracts of various cell lines, using ULBP2 antibody. 100 μL 6至11个工作日
非结合性 WB Western blot analysis of ULBP2 expression in mouse ovary (A), rat ovary (B) whole cell lysates. 100 μL 11至18个工作日
非结合性 WB   100 μL 2至3个工作日


Human UL16 Binding Protein 2 (ULBP2) interaction partners

  1. Data show that the response of NK cells activated by ULBP2 was augmented by an interaction between NKG2D ligand 2 protein (ULBP2)-bound natural killer group 2D (NKG2D) and IL- interleukin 15 receptor (IL-15R).

  2. NK cells are important cytotoxic cells in the immune system, and the activated NKG2D receptor on the NK cell surface can bind to NKG2D ligands expressed in tumor cells, enabling NK cells to activate and kill tumor cells. (Review)

  3. High ULBP2 expression is associated with lymphoma.

  4. IMP3 directly interacts with ULBP2 mRNA, leading to ULBP2 transcript destabilization and reduced ULBP2 surface expression and indirectly downregulates MICB with a mechanism functionally distinct from that of ULBP2.

  5. By suppressing AR and up-regulating ULBP2 in HCC, cisplatin could up-regulate cytotoxicity of NK cells to better target HCC.

  6. human tumor cells lost their surface expression of ULBP2, but not ULBP1 and ULBP3, during NK cell-mediated cytolysis.

  7. This study suggests that NKG2D ligands shedding of MICA, MICB and ULBP-2 is a novel pathway in endometriosis complex pathogenesis that impairs Natural Killer Cells cell function.

  8. Varicella-Zoster Virus differentially modulates expression of the NKG2D ligands by upregulating MICA expression and reducing ULBP2 and ULBP3 expression in the infected cells.

  9. A conserved WW domain-like motif regulates CD74 antigen-dependent cell-surface transport of the NKG2D ligand ULBP2.

  10. NKG2D and NKG2DL are involved in allergen-induced activation of dendritic epidermal T cells and the NKG2D/NKG2DL pathway might be a potential target for treatment of contact hypersensitivity.

  11. Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.

  12. Data inticate that heat shock protein 60 (HSP60) interacted constitutively with NKG2D ligand ULBP2 and phosphatase of regenerating liver 3 (PRL-3) regulated HSP60 tyrosine phosphorylation.

  13. Results suggest that ULBP2 is expressed and released from cervical cancer cells by CRF, which regulates NKG2D expression in natural killer cells.

  14. c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells.

  15. the NKG2D ligand ULBP2 is transported to the cell surface through an endosomal pathway dependent on protein kinase C and lysosomal integrity. ULBP2 surface transport is dependent on the invariant chain.

  16. This study provides for the first time, the c-Myc dependent regulation of NKG2D ligands, ULBP1/2/3 in acute myeloid leukemia.

  17. Vpr augments ULBP2 expression on both infected and uninfected bystander cells during HIV-1 infection of primary CD4+ T lymphocytes.

  18. Study shows that tumor-suppressive miR-34a and miR-34c act as ULBP2 repressors. Findings also implicate p53 in ULBP2 regulation, emphasizing the role of the specific NKG2DL in tumor immune surveillance.

  19. Data show that VSV infection caused an active suppression of NKG2D-ligand surface expression, affecting both endogenous and histone deacetylase (HDAC)-inhibitor induced MICA, MICB and ULBP-2 expression.

  20. Findings define the involvement of p53 in the regulation of ULBP1 and ULBP2 which enhance NK cell-mediated target recognition.

ULBP2 抗原简介


Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface.

Gene names and symbols associated with ULBP2

  • UL16 binding protein 2 (ULBP2) 抗体
  • NKG2D ligand 2-like (LOC100355436) 抗体
  • N2DL2 抗体
  • RAET1H 抗体

Protein level used designations for ULBP2

ALCAN-alpha , N2DL-2 , NKG2D ligand 2 , NKG2DL2 , UL16-binding protein 2 , retinoic acid early transcript 1 H , retinoic acid early transcript 1H

80328 Homo sapiens
100355436 Oryctolagus cuniculus
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