anti-Tumor Protein P63 (TP63) 抗体

TP63 encodes a member of the p53 family of transcription factors. 再加上,我们可以发p63 试剂盒 (31)p63 蛋白 (10)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
TP63 8626 Q9H3D4
TP63 246334 Q9JJP6
TP63 22061 O88898
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产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB TP63 Antibody (C-term) (ABIN657886) western blot analysis in MDA-MB231 cell line lysates (35 µg/lane). This demonstrates the TP63 antibody detected the TP63 protein (arrow). Anti-TP63 Antibody (C-term) at 1:1000 dilution + HACAT whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 77 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL Log in to see 10至11个工作日
非结合性 ICC, IHC (p), WB Anti-p63 Picoband antibody,  IHC(P): Human Oesophagus Squama Cancer Tissue Anti-p63 Picoband antibody,  All lanes: Anti P63  at 0.5ug/ml WB: Recombinant Human P63 Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD 100 μg Log in to see 4至6个工作日
山羊 非结合性 ELISA, WB 0.1 mg Log in to see 2至3个工作日
非结合性 ICC, IHC (p), WB Anti-p63 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue Anti-p63 antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: SMMC Cell Lysate Lane 3: COLO320 Cell Lysate Lane 4: A549 Cell Lysate Lane 5: SGC Cell Lysate 100 μg Log in to see 4至6个工作日
非结合性 IHC, WB Immunohistochemistry of paraffin-embedded rat kidney using TP63 antibody at dilution of 1:100 (x400 lens). 100 μL Log in to see 16 Days
小鼠 非结合性 WB TP63 Antibody (Ascites) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TP63 antibody detected the TP63 protein (arrow). 0.1 mL Log in to see 10至11个工作日
小鼠 非结合性 ELISA, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 Detection limit for recombinant GST tagged TP63 is approximately 0.3ng/ml as a capture antibody. 100 μg Log in to see 8至11个工作日
非结合性 IHC (p) Immunochemical staining of human P63 in human skin with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections). Immunochemical staining of human P63 in human prostate with rabbit polyclonal antibody (0.5 µg/mL, formalin-fixed paraffin embedded sections). 100 μg Log in to see 20至21个工作日
非结合性 WB Human p63 / TP63 Western blot (WB) 13067 100 μg Log in to see 20至21个工作日
非结合性 IHC (p) Immunochemical staining of human P63 in human prostatic carcinoma with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Immunochemical staining of human P63 in human prostate with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). 100 μg Log in to see 20至21个工作日

引用最多的anti-p63 抗体

  1. Human Polyclonal p63 Primary Antibody for WB - ABIN657886 : Miki, Kubo, Takahashi, Yoon, Kim, Lee, Zo, Lee, Hosono, Morizono, Tsunoda, Kamatani, Chayama, Takahashi, Inazawa, Nakamura, Daigo: Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. in Nature genetics 2010 (PubMed)
    Show all 2 Pubmed References


Human Tumor Protein P63 (TP63) interaction partners

  1. In leukoplakia, increased expression of survivin reflects on the increased expression of ki-67 (显示 MKI67 抗体) and p63 (显示 RPE65 抗体).

  2. Gene-gene interaction between MSX1 (显示 MSX1 抗体) and TP63 may influence the risk of nonsyndromic cleft lip with or without cleft palate in Asian populations.

  3. High N-terminally truncated isoform of p63 (显示 RPE65 抗体) expression is associated with squamous cell carcinogenesis.

  4. The rs35592567 polymorphism in TP63 affected the expression of TP63 by interfering with its interaction with miR (显示 MLXIP 抗体)-140, and could serve as an explanation for the increased risk of Gastric Cancer.

  5. The data from this study showed that p63 was a tumor suppressor mainly through regulating PTEN in chondrosarcoma cells.

  6. we first demonstrated that upregulation of P63 (显示 RPE65 抗体) in the cartilage tissues of osteoarthritis (OA) patients inhibited chondrocyte autophagy thereby contributing to the malignant progression of OA.

  7. high DeltaNp63beta expression up-regulates KLK6 (显示 KLK1 抗体)-PAR2 (显示 F2RL1 抗体) and down-regulates PAR1 (显示 MARK2 抗体), inducing malignant transformation in oral epithelium with stimulating proliferation through ERK (显示 EPHB2 抗体) signal activation

  8. multiple ankyloblepharon-ectodermal defects-cleft lip/palate syndrome-associated p63 (显示 RPE65 抗体) mutations, but not those causative of other diseases, lead to thermodynamic protein destabilization, misfolding, and aggregation

  9. LINC01503 is increased in squamous cell carcinoma (SCC (显示 CYP11A1 抗体)) cells compared with non-tumor cells. TP63 bound to the super enhancer at the LINC01503 locus activates its transcription which promotes SCC (显示 CYP11A1 抗体) cell proliferation, migration, invasion, and growth of xenograft tumors.

  10. we provide evidence that S100A7 (显示 S100A7 抗体) also inhibits YAP (显示 YAP1 抗体) expression and activity through p65 (显示 GORASP1 抗体)/NFkappaB (显示 NFKB1 抗体)-mediated repression of DeltaNp63, and S100A7 (显示 S100A7 抗体) represses drug-induced apoptosis via inhibition of YAP (显示 YAP1 抗体).

Horse (Equine) Tumor Protein P63 (TP63) interaction partners

  1. p63 expression was significantly lower in the chronic laminitic hoof than in that of control horses

Zebrafish Tumor Protein P63 (TP63) interaction partners

  1. they unravel essential roles of TAp63 and p53 (显示 TP53 抗体) to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch (显示 NOTCH1 抗体) signalling and caspase 3 (显示 CASP3 抗体) activity.

  2. the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma (显示 BBC3 抗体) transcription in response to ER stress.

  3. Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)

  4. DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)

  5. rps19 (显示 RPS19 抗体)-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 (显示 TP53 抗体) and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia

Mouse (Murine) Tumor Protein P63 (TP63) interaction partners

  1. The results indicate that ZIP10 (显示 SLC39A10 抗体) plays important roles in epidermal development via, at least in part, the ZIP10 (显示 SLC39A10 抗体)-zinc-p63 (显示 CKAP4 抗体) signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis.

  2. Notch signaling maintains p63 levels and horizontal basal cell (HBC) dormancy, in contrast to its suppression of p63 expression in other tissues. Additionally, Notch1, but not Notch2, is required to maintain HBC dormancy after selective neuronal degeneration.

  3. present study, we provided a role for IDH2 (显示 IDH2 抗体) in protection against UVB-induced skin damage and a new connection between IDH2 (显示 IDH2 抗体) and DeltaNp63.

  4. Overexpression of DeltaNp63 in transgenic mouse epidermis results in a severe skin phenotype that shares many of the key clinical, histological and molecular features associated with Atopic dermatitis and IL-31 (显示 IL31 抗体) and IL-33 (显示 IL33 抗体) are key players in the signaling pathways.

  5. cells expressing both p63 (显示 CKAP4 抗体) and p73 (显示 ARHGAP24 抗体) exist in mouse epidermis and hair follicle and that hetero-tetramer complexes can be detected by immunoprecipitation in differentiating keratinocytes.

  6. Data suggest that this the selective targeting of genes by tumor suppressor protein (显示 TP53 抗体) p63 (p63 (显示 CKAP4 抗体)) correlates with subtle, but measurable transcriptional differences in mouse and human keratinocytes that converges on major metabolic processes, which often exhibit species-specific trends.

  7. p63alpha protein up-regulates heat shock protein 70 (显示 HSP70 抗体) expression via E2F1 transcription factor (显示 E2F1 抗体) 1 (显示 HNF1A 抗体), promoting Wasf3/Wave3 (显示 WASF3 抗体)/MMP9 (显示 MMP9 抗体) signaling and bladder cancer invasion

  8. these results therefore highlight an unanticipated role for p53 (显示 TP53 抗体) family proteins in a regulatory network that integrates essential Wnt (显示 WNT2 抗体)-Tcf (显示 HNF4A 抗体) and nodal-Smad (显示 SMAD1 抗体) inputs.

  9. the double mutant spermatocytes apoptosed at late pachynema because of sex body deficiency; thus p53 (显示 TP53 抗体) and TAp63 are dispensable for arrest caused by sex body defects. These data affirm that recombination-dependent and sex body-deficient arrests occur via genetically separable mechanisms.

  10. TGFb3 (显示 TGFB3 抗体)-induced down-regulation of p63 (显示 CKAP4 抗体) in the medial edge epithelia of the palatal shelves is a pre-requisite for palatal fusion by facilitating periderm migration from, and reducing the proliferative potential of, the midline epithelial seam thereby preventing cleft palate.

Xenopus laevis Tumor Protein P63 (TP63) interaction partners

  1. Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.

  2. The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4 (显示 BMP4 抗体).

  3. The role of p63 as a negative Wnt (显示 WNT2 抗体)-regulator thus matches with the frequently observed downregulation of p63 during tumor progression, when cancer cells adopt a more mesenchymal, invasive phenotype.

p63 (TP63) 抗原简介


This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)\; split-hand/foot malformation 4 (SHFM4)\; ankyloblepharon-ectodermal defects-cleft lip/palate\; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth)\; limb-mammary syndrome\; Rap-Hodgkin syndrome (RHS)\; and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined.

Gene names and symbols associated with anti-Tumor Protein P63 (TP63) 抗体

  • tumor protein p63 (TP63) 抗体
  • tumor protein p63 (tp63) 抗体
  • tumor protein p63 (Tp63) 抗体
  • transformation related protein 63 (Trp63) 抗体
  • tumor protein p63 L homeolog (tp63.L) 抗体
  • AI462811 抗体
  • AIS 抗体
  • B(p51A) 抗体
  • B(p51B) 抗体
  • DNp63 抗体
  • EEC3 抗体
  • id:ibd3516 抗体
  • ket 抗体
  • LMS 抗体
  • NBP 抗体
  • np63 抗体
  • OFC8 抗体
  • p40 抗体
  • p51 抗体
  • P51/P63 抗体
  • p53CP 抗体
  • P63 抗体
  • p73H 抗体
  • P73l 抗体
  • RHS 抗体
  • SHFM4 抗体
  • TP53CP 抗体
  • TP53L 抗体
  • Tp63 抗体
  • Tp73l 抗体
  • tp73l-A 抗体
  • Trp53rp1 抗体
  • trp63 抗体
  • wu:fc89f04 抗体
  • wu:fk85h07 抗体
  • wu:fk88b02 抗体
  • Xp63 抗体

Protein level used designations for anti-Tumor Protein P63 (TP63) 抗体

CUSP , amplified in squamous cell carcinoma , chronic ulcerative stomatitis protein , keratinocyte transcription factor KET , transformation-related protein 63 , tumor protein 63 , tumor protein p53-competing protein , tumor protein p63 deltaN isoform delta , tumor protein p63 , delta-Np63 , fc89f04 , transformation related protein 63 , tumor protein 63 kDa , tumor protein 63-like

8626 Homo sapiens
100059752 Equus caballus
100170632 Oryzias latipes
260407 Danio rerio
703997 Macaca mulatta
615335 Bos taurus
246334 Rattus norvegicus
374269 Gallus gallus
460930 Pan troglodytes
488125 Canis lupus familiaris
100227936 Taeniopygia guttata
100386953 Callithrix jacchus
100444448 Pongo abelii
100606847 Nomascus leucogenys
22061 Mus musculus
373640 Xenopus laevis
100625258 Sus scrofa
100355881 Oryctolagus cuniculus
100732143 Cavia porcellus
101108874 Ovis aries
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