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The protein encoded by TRIM8 is a member of the tripartite motif (TRIM) family.
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TRIM8 activates STAT3 (显示 STAT3 蛋白) by suppressing the expression of PIAS3 (显示 PIAS3 蛋白), an inhibitor of STAT3 (显示 STAT3 蛋白), most likely through E3-mediated ubiquitination and proteasomal degradation.
we provided evidence that TRIM8 and its regulators miR-17-5p and miR (显示 MLXIP 蛋白)-106b-5 participate to a feedback loop controlling cell proliferation through the reciprocal modulation of p53 (显示 TP53 蛋白), miR (显示 MLXIP 蛋白)-34a and N-MYC (显示 MYCN 蛋白).
A pathogenic effect of a heterozygous truncating mutation in the tripartite motif containing 8 (TRIM8) gene on the postnatal development of the human brain.
Our study provides evidences that TRIM8 may participate in the carcinogenesis and progression of glioma and that the transcriptional repression of TRIM8 might have potential value for predicting poor prognosis in glioma patients.
These findings provide the first mechanistic link between TRIM8 and the drug resistance of clear cell Renal Cell Carcinoma (显示 MOK 蛋白)
Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene (显示 RAB1A 蛋白), is involved in positive regulation of TNF (显示 TNF 蛋白) induced NF-kappaB (显示 NFKB1 蛋白) pathway.
TRIM8 is a p53 (显示 TP53 蛋白) direct target gene that induces p53 (显示 TP53 蛋白) stabilization and promotes the degradation of MDM2 (显示 MDM2 蛋白) protein.
Tripartite motif 8 (TRIM8) modulates TNFalpha (显示 TNF 蛋白)- and IL-1beta (显示 IL1B 蛋白)-triggered NF-kappaB (显示 NFKB1 蛋白) activation by targeting TAK1 (显示 MAP3K7 蛋白) for K63-linked polyubiquitination.
TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90beta and consequently regulates transcription of Nanog in embryonic stem cells.
These findings indicate that TRIM8 enhances the STAT3 (显示 STAT3 蛋白)-dependent signal pathway by inhibiting the function of PIAS3 (显示 PIAS3 蛋白).
these studies reveal an additional regulatory function of TRIM8 in innate immune responses: TRIM8 catalyzes polyubiquitination of TRIF (显示 RNF138 蛋白), resulting in disruption of TRIF (显示 RNF138 蛋白)-TBK1 (显示 TBK1 蛋白) interaction
TRIM8 plays a deleterious role in pressure overload-induced cardiac hypertrophy by accelerating the activation of TAK1 (显示 NR2C2 蛋白)-dependent signaling pathways.
potent regulator that exacerbates steatohepatitis and metabolic disorders dependent on its binding and ubiquitinating capacity on transforming growth factor-beta-activated kinase 1 (显示 MAP3K7 蛋白)
TRIM8 has pro-inflammatory effect on Pseudomonas aeruginosa -induced keratitis
Gerp transcribes interferon-gamma (显示 IFNG 蛋白) in epithelial and lymphoid cells and is expressed almost ubiquitously in tissues.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes.
glioblastoma expressed ring finger protein
, glioblastoma-expressed RING finger protein
, probable E3 ubiquitin-protein ligase TRIM8
, ring finger protein 27
, tripartite motif protein TRIM8
, tripartite motif-containing 8
, tripartite motif-containing protein 8
, tripartite motif protein 8