anti-Spi-B Transcription Factor (Spi-1/PU.1 Related) (SPIB) 抗体

The protein encoded by SPIB is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. 再加上,我们可以发SPIB 蛋白 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SPIB 6689 Q01892
SPIB 272382 O35906
SPIB 499146 Q5EBA3
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antibodies-online.cn销售最多的anti-SPIB 抗体

Showing 10 out of 43 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-SPIB Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  NCI-H226 cell lysate 100 μL 2至3个工作日
Cow 非结合性 WB WB Suggested Anti-SPIB Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Daudi cell lysate SPIB is supported by BioGPS gene expression data to be expressed in Daudi WB Suggested Anti-SPIB Antibody Titration: 3 ug/ml ELISA Titer: 1:62500 Positive Control: spleen tissue lysate SPIB is supported by RNA-seq  data to be expressed in spleen 100 μL 2至3个工作日
小鼠 非结合性 ELISA, FACS, IF/ICC, IHC, WB 100 μL 11至16个工作日
小鼠 非结合性 ICC, FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of NIH3T3 cells using SPIB mouse mAb (green) and negative control (red) . 100 μL 3至4个工作日
小鼠 非结合性 ELISA, FACS, IF, IHC, IHC (p), WB 100 μL 11至14个工作日
Cow 非结合性 WB 100 μL 11至14个工作日
非结合性 WB 100 μg 11至14个工作日
非结合性 ELISA, WB 100 μL 2至3个工作日
非结合性 ELISA, IHC (p), WB   0.1 mg 2至3个工作日
非结合性 IHC, WB Western blot analysis of extracts of various cell lines, using SPIB antibody. Immunofluorescence analysis of A549 cell using SPIB antibody. Blue: DAPI for nuclear staining. 100 μL 11至13个工作日

引用最多的anti-SPIB 抗体

  1. Mouse (Murine) Polyclonal SPIB Primary Antibody for CyTOF, FACS - ABIN4899321 : Sehgal, Kobayashi, Donaldson, Mabbott: c-Rel is dispensable for the differentiation and functional maturation of M cells in the follicle-associated epithelium. in Immunobiology 2016 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal SPIB Primary Antibody for ICC, FACS - ABIN1098113 : Marshall, Dunham, Major: Transcription factor Spi-B binds unique sequences present in the tandem repeat promoter/enhancer of JC virus and supports viral activity. in The Journal of general virology 2010 (PubMed)
    Show all 2 Pubmed References

  3. Cow (Bovine) Polyclonal SPIB Primary Antibody for WB - ABIN2780475 : Dontje, Schotte, Cupedo, Nagasawa, Scheeren, Gimeno, Spits, Blom: Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B. in Blood 2006 (PubMed)
    Show all 2 Pubmed References


Xenopus laevis Spi-B Transcription Factor (Spi-1/PU.1 Related) (SPIB) interaction partners

  1. spib is required for myeloid specification, and, in its absence, primitive myeloid cells retain hemangioblast-like characteristics and fail to migrate.

Human Spi-B Transcription Factor (Spi-1/PU.1 Related) (SPIB) interaction partners

  1. Results provide evidence that SPIB is a specific transcription factor that participates in pH-mediated regulation of AQP1 gene expression.

  2. These results show that the mechanism of action of lenalidomide in ABC-DLBCL cells involves downregulation of SPIB transcription by cereblon-induced degradation of IKAROS.

  3. High SPIB expression is associated with Lung Cancer metastasis.

  4. our data indicate that SPIB expression is a clinically novel poor prognostic factor in DLBCL that contributes to treatment resistance, at least in part, through an anti-apoptotic mechanism.

  5. Findings establish a molecular hierarchy among POU2F2, SPIB and ID2 during B-cell differentiation, and suggest that aberrant expression of these transcription factors plays an important role in arresting plasmacytic differentiation in WM.

  6. The SRC family tyrosine kinase HCK and the ETS family transcription factors SPIB and EHF regulate transcytosis across a human follicle-associated epithelium model.

  7. Our data indicate that the CBFbeta-SMMHC's C-terminus is essential to induce embryonic hematopoietic defects and leukemogenesis.

  8. Fine mapping identified 26 single-nucleotide polymorphisms (SNPs) across the CLEC16A-SOCS1 and 11 SNPs across the SPIB locus with significant association to primary biliary cirrhosis.

  9. Data show that in a cereblon-dependent fashion, lenalidomide downregulates IRF4 and SPIB, transcription factors that together prevent IFNbeta production.

  10. The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1.

  11. The effect of mutating Spi-B-binding sites within the JC virus promoter/enhancer on early viral gene expression strongly suggests a role for Spi-B binding to the viral promoter/enhancer in the activation of early viral gene expression.

  12. These results suggest that Spi-B could regulate JC virus gene expression in susceptible cells, and may play an important role in JC virus activity in the immune and nervous systems.

  13. Spi-B is expressed in plasmacytoid dendritic cell precursors and inhibits T-, B-, and NK-cell development

  14. Spi-B is a key regulator of human pDC development.

  15. c-Myb and c-Ets family members (Ets-1/2, PU.1, and Spi-B) control hGR 1A promoter regulation in T- and B-lymphoblast cells

  16. DL1-induced activation of the Notch1 pathway controls the lineage commitment of early thymic precursors by altering the levels between Spi-B and GATA-3.

  17. By chromatin immunoprecipitation and assays using an inducible Spi-B construct BLIMP1 and XBP-1 were identified as direct target genes of Spi-B mediated repression.

  18. findings suggest that the concurrent action of Spi-B and E2-2 controls the development of progenitor cells into the plasmacytoid dendritic cell lineage

Mouse (Murine) Spi-B Transcription Factor (Spi-1/PU.1 Related) (SPIB) interaction partners

  1. Mice lacking both PU.1 and SpiB in mature B cells do not generate germinal centers and high-affinity antibody after protein immunization. PU.1 and SpiB double-deficient B cells have a survival defect after engagement of CD40 or Toll-like receptors (TLR), despite paradoxically enhanced plasma cell differentiation.

  2. Mechanistic analysis indicated that E47 activated expression of the transcription factor Spi-B and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 expression. These findings demonstrate that the balance of Id3 and E47 controls the maintenance of Foxp3 expression in Treg cells and, thus, contributes to Treg cell plasticity.

  3. Our results suggest that complementary biological functions of PU.1 and Spi-B may be explained by their interaction with a similar set of regions in the genome of B cells.

  4. Nfkb1 transcriptional activation by PU.1 and Spi-B promotes toll-like receptor-mediated B cell proliferation.

  5. Data show that transcription factor Spi-B-mediated negative feedback regulation limited medullary thymic epithelial cells (mTECs) development.

  6. there is a small M-cell population with developmental regulation that is Spi-B independent; however, Spi-B is probably a candidate master regulator of M-cell functional maturation and development by another pathway.

  7. Data indicate that the developmental defects of plasmacytoid dendritic cells (pDC) in Spi-B-deficient mice were more prominent in the bone marrow.

  8. The Blnk promoter contains a predicted PU.1 and/or Spi-B binding site that is required for promoter activity and occupied by PU.1 and/or Spi-B.

  9. RankL-induced expression of SpiB is essential for Lgr5 stem cell-derived epithelial precursors to develop into Peyer's patch M cells

  10. Spi-B is an essential transcription factor that regulates M-cell differentiation.

  11. Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C.

  12. DNA microarray analyses enabled us to identify two genes inhibited by v-Abl that encode the Igk 3' enhancer-binding transcription factors Spi-B and IRF-4.

  13. Reduction of Spi-B activity in pro-B cells promotes their differentiation to a stage intermediate between late pro-B cells and large pre-B cells.

  14. potential positive autoregulatory loop mediated through an upstream regulatory element is essential for proper PU.1 gene expression

  15. Spi-B function is necessary for efficient development of fetal thymocytes at the CD4-CD8-CD44-CD25+ (DN) checkpoint to the CD4+CD8+ (DP) stage; dysregulation of Spi-B expression results in a dose-dependent perturbation of thymocyte development.

  16. Maintenance of the B-2 type cell phenotype requires relatively high levels of PU.1, but B-1 cells require little.

  17. The present findings establish a hierarchy between these two factors and provide a molecular link between OBF-1 and B cell receptor signaling.

SPIB 抗原简介


The protein encoded by this gene is a transcriptional activator that binds to the PU-box (5'-GAGGAA-3') and acts as a lymphoid-specific enhancer. Four transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SPIB

  • Spi-B transcription factor L homeolog (spib.L) 抗体
  • Spi-B transcription factor (SPIB) 抗体
  • Spi-B transcription factor (Spi-1/PU.1 related) (Spib) 抗体
  • Spi-B transcription factor (Spib) 抗体
  • B42b-like 抗体
  • Spi-B 抗体
  • spib 抗体
  • spiba 抗体

Protein level used designations for SPIB

Spi-B transcription factor (Spi-1/PU.1 related) a , transcription factor Spi-B , Ets transcription factor Spi-B , Spi-1/PU.1 related

379335 Xenopus laevis
6689 Homo sapiens
100688036 Canis lupus familiaris
784460 Bos taurus
272382 Mus musculus
499146 Rattus norvegicus
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