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SPEN encodes a hormone inducible transcriptional repressor.
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Human Polyclonal SPEN Primary Antibody for ICC, IF - ABIN4355627
McHugh, Chen, Chow, Surka, Tran, McDonel, Pandya-Jones, Blanco, Burghard, Moradian, Sweredoski, Shishkin, Su, Lander, Hess, Plath, Guttman: The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3. in Nature 2015
Human Polyclonal SPEN Primary Antibody for ELISA - ABIN251251
Hiriart, Gruffat, Buisson, Mikaelian, Keppler, Meresse, Mercher, Bernard, Sergeant, Manet: Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. in The Journal of biological chemistry 2005
our data demonstrate a role for SPEN in the regulation of primary cilia formation and cell migration in breast cancer cells, which may collectively explain why its expression is associated with time to metastasis in cohorts of patients with ERalpha (显示 ESR1 抗体)-negative breast cancers.
SPEN is a novel tumor-suppressor gene that may be clinically useful as a predictive biomarker of tamoxifen response in ERalpha (显示 ESR1 抗体)-positive breast cancers.
SPEN mutations were associated with diffuse large B-cell lymphoma with hepatitis C virus infection.
Phosphorylation of the CK2 site on SMRT significantly increased affinity for SHARP.
These results demonstrate a role for the inactivation of SHARP transcription in DM1 biology.
MINT3 (显示 APBA3 抗体) and MINT17 were informative for patient grouping to predict local recurrence in rectal cancer patients
SHARP is a novel component of the HDAC (显示 HDAC3 抗体) corepressor complex, recruited by RBP (显示 RBP4 抗体)-Jkappa to repress transcription of target genes in the absence of activated Notch (显示 NOTCH1 抗体).
the conserved function of the SPOC domain of SHARP is to mediate interaction with SMRT/NCoR (显示 NCOR1 抗体) corepressors, and that Spen proteins play an essential role in the repression complex
both the androgen receptor (显示 AR 抗体) interacting domains of the coactivator SRC1 (显示 SRC 抗体) and of the corepressor SMRT compete for interaction with the androgen receptor (显示 AR 抗体) N-terminus
Pak1 (显示 PAK1 抗体)-SHARP interaction plays an essential role in enhancing the corepressor functions of SHARP, thereby modulating Notch (显示 NOTCH1 抗体) signaling in human cancer cells.
Spenito (显示 RBM15 抗体), a small Spen family member, counteracted Spen function in fat regulation. Finally, mouse Spen and Spenito (显示 RBM15 抗体) transcript levels scaled directly with body fat in vivo, suggesting a conserved role in fat liberation and catabolism. This study demonstrates that Spen is a key regulator of energy balance and provides a molecular context to understand the metabolic defects that arise from Spen dysfunction.
Spen is required for gene repression by Xist. Spen is not required for Xist RNA localization and the recruitment of chromatin modifications.
Spen is required for Xist-mediated silencing.
results suggest that Xist silences transcription by directly interacting with SHARP, recruiting SMRT, activating HDAC3 (显示 HDAC3 抗体), and deacetylating histones to exclude Pol II (显示 0 抗体) across the X chromosome
MINT forms a high affinity complex with CSL (显示 SMPX 抗体); the domains of MINT and CSL (显示 SMPX 抗体) that are necessary and sufficient for complex formation are delineated
MINT plays an important role in tooth development, in particular, epithelial morphogenesis
Notch1 (显示 NOTCH1 抗体) in concert with Notch2 (显示 NOTCH2 抗体) contributes to the morphogenesis of renal vesicles into S-shaped bodies in a RBP-J (显示 RBPJ 抗体)-dependent manner.
Msx2-interacting nuclear target protein (MINT) competed with the intracellular region of Notch (显示 NOTCH1 抗体) for binding to a DNA binding protein (显示 HSF4 抗体) RBP-J (显示 RBPJ 抗体) and suppressed the transactivation activity of Notch (显示 NOTCH1 抗体) signaling.
Stra13, Dec and Sharp (Mint) bHLH repressors are dynamically regulated during mammary gland development and may function to regulate apoptosis
MINT enhances Runx2 (显示 RUNX2 抗体) activation of multiprotein complexes assembled by the OCFRE
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator\; this binding can modulate the activity of both liganded and nonliganded steroid receptors.
Msx2 interacting nuclear target (MINT) homolog
, SMART/HDAC1 associated repressor protein
, SMART/HDAC1-associated repressor protein
, msx2-interacting protein
, nuclear receptor transcription cofactor
, spen homolog, transcriptional regulator (Drosophila)
, Msx2 interacting nuclear target protein