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SP3 belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. 再加上，我们可以发Sp3 Transcription Factor 试剂盒 (1) 和 和数多这个蛋白质的别的产品。
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Sp1 (显示 PSG1 抗体), Sp3 and Sp4 (显示 SP4 抗体) are non-oncogene (显示 RAB1A 抗体) addiction (NOA (显示 DLAT 抗体)) genes and are attractive drug targets for individual and combined cancer chemotherapies.
High SP3 expression is associated with hepatocellular carcinoma.
we established a new regulatory model of COL1A1 (显示 COL1A1 抗体) regulation by HIF-1 (显示 HIF1A 抗体), and bring out its relationship with Sp3 transcription factor. In a fundamental level, these findings give insights in the mechanisms controlling COL1A1 (显示 COL1A1 抗体) gene expression.
Data indicate that the antitumor activity of trefoil factor 2 (TFF2 (显示 TFF2 抗体)) is mediated by an interaction with the transcription factor Sp3 (Sp3) in gastric cancer cells.
demonstrate that a 186bp region is the minimal essential region and that Sp3-GC1 (显示 OLFM4 抗体) binding is essential to the basal expression of KLF5 (显示 KLF5 抗体)
Sp1 (显示 PSG1 抗体) and Sp3 are not only essential for the basal transcription of the ek1 (显示 EPHA3 抗体) gene, their accessibility to the target site on the ek1 (显示 EPHA3 抗体) promoter is regulated by histone protein modification in a cell line dependent manner.
Human SP1 and SP3 transcription factors regulate MALAT1 expression in hepatocellular carcinoma.
result indicated that promoter binding by Sp1 (显示 PSG1 抗体)/Sp3 was essential, but not a limiting step, for hTERT transcription
Sp3 was found to be a major regulator of BNIP3 (显示 BNIP3 抗体) in prostate cancer.
stimulates CCR7 (显示 CCR7 抗体) expression during the course of dendritic cell maturation
This resulted in Sp1 (显示 SP1 抗体) displacement from the promoter and binding of Sp3 to it, leading to p300 (显示 NOTCH1 抗体) recruitment and histone acetylation, activating transcription. This is the first study addressing the mechanisms of physiological TLR5 (显示 TLR5 抗体) expression in the intestine. Additionally, a novel insight is gained into Sp1 (显示 SP1 抗体)/Sp3-mediated gene regulation that may apply to other genes
Sp3 binds and activates the FGFR4 (显示 FGFR4 抗体) promoter.
Dp71 (显示 DMD 抗体) expression in hepatic cells is carried out, in part, by YY1 (显示 YY1 抗体)-, Sp1 (显示 SP1 抗体)- and Sp3-mediated transcription from the Dp71 (显示 DMD 抗体) promoter.
Our results unveil strikingly different recruitment mechanisms of Sp1 (显示 SP1 抗体)/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
Sp1 (显示 SP1 抗体)/Sp3 transcription factors have roles in regulating hallmarks of megakaryocyte maturation and platelet formation and function
Sp1 (显示 SP1 抗体)/3 transcription factors trigger Mina (显示 MINA 抗体) expression through additive activity targeted to a cluster of four Sp1 (显示 SP1 抗体)/3 binding sites forming the P1 promoter.
an interplay between Sp1 (显示 SP1 抗体) and Sp3 as a mechanism involved in the control of Fiat (显示 TXLNG 抗体) gene expression in osteoblasts.
Oct-6 (显示 POU3F1 抗体) and Oct-11 (显示 POU2F3 抗体) contribute to the regulation of loricrin (显示 LOR 抗体) gene transcription via interaction with AP-1 (显示 JUN 抗体) factors and Sp1 (显示 SP1 抗体)/Sp3.
inhibition of FGF-10 (显示 FGF10 抗体) by inflammatory signaling involves the NF-kappaB (显示 NFKB1 抗体)-dependent interactions between RELA (显示 NFkBP65 抗体), SP3, and the Fgf-10 (显示 FGF10 抗体) promoter.
Three GC boxes within the proximal promoter of the murine pyruvate carboxylase (显示 PC 抗体) gene bind Sp1 (显示 SP1 抗体)/Sp3
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13.
Sp3 transcription factor
, sp3 transcription factor
, transcription factor Sp3
, specificity protein 3
, GC-binding transcription factor Sp3