蛋白简介

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD)\; a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with SMG7

• Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) (Smg7) 抗体
• SMG7, nonsense mediated mRNA decay factor (SMG7) 抗体

• 9430023P16Rik 抗体
• C1orf16 抗体
• EST1C 抗体
• mKIAA0250 抗体
• SGA56M 抗体

Protein level used designations for SMG7

EST1-like protein C , protein SMG7 , EST1 telomerase component homolog C , breast cancer-associated antigen SGA-56M , ever shorter telomeres 1C , smg-7 homolog, nonsense mediated mRNA decay factor