The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008].
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Vallenius, Mäkelä: "Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein." in: Journal of cell science, Vol. 115, Issue Pt 10, pp. 2067-73, (2002) (PubMed).