anti-SMAD, Mothers Against DPP Homolog 5 (SMAD5) 抗体

The protein encoded by SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. 再加上,我们可以发SMAD5 蛋白 (14)SMAD5 试剂盒 (10)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SMAD5 4090 Q99717
SMAD5 59328 Q9R1V3
SMAD5 17129 P97454
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antibodies-online.cn销售最多的anti-SMAD5 抗体

Showing 10 out of 127 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-SMAD5 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  HepG2 cell lysate Host:  Rat  Target Name:  SMAD5  Sample Tissue:  Rat Liver  Antibody Dilution:  1ug/ml 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 WB Western blot analysis of SMAD5 expression in HeLa (A), mouse testis (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13至14个工作日
$487.50
详细
小鼠 非结合性 ELISA, FACS, ICC, IHC, WB Figure 1: Western blot analysis using SMAD5 mouse mAb against Hela (1), SK-N-SH (2), PC-12 (3), Jurkat (4), and K562 (5) cell lysate. Dilution: 1/500 - 1/2000 Figure 2: Immunohistochemical analysis of paraffin-embedded brain tissues (left) and lung cancer tissues (right) using SMAD5 mouse mAb with DAB staining. Dilution: 1/200 - 1/1000 100 μL Log in to see 8至11个工作日
$491.79
详细
小鼠 非结合性 ELISA, FACS, IF, IHC, WB 100 μL Log in to see 11至14个工作日
$522.50
详细
非结合性 FACS, IF, IHC, WB Western blot analysis of extracts of various cell lines, using SMAD5 antibody. 100 μL Log in to see 16 Days
$366.77
详细
非结合性 ICC, IF, WB ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using SMAD5, antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with  (Red) at 1:2000. 100 μL Log in to see 3至4个工作日
$466.18
详细
小鼠 非结合性 ELISA, IF, WB Immunofluorescence of monoclonal antibody to SMAD5 on HeLa cell (antibody concentration 10 µg/mL). SMAD5 monoclonal antibody (M01), clone 2D7. Western Blot analysis of SMAD5 expression in Jurkat. 100 μg Log in to see 8至11个工作日
$527.50
详细
非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human K562 Cells; Lane2: Human Hela Cells; Lane3: Human Jurkat Cells. 100 μg Log in to see 13至16个工作日
$350.00
详细
非结合性 ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Human Uterus, antibody was diluted at 1:100. 100 μL Log in to see 16 Days
$181.73
详细
Cow 非结合性 WB 100 μg Log in to see 11至14个工作日
$493.17
详细

引用最多的anti-SMAD5 抗体

  1. Human Polyclonal SMAD5 Primary Antibody for WB - ABIN1881816 : Park, Lee, Ahn, Kim: Predicting the multi-modal binding propensity of small molecules: towards an understanding of drug promiscuity. in Molecular bioSystems 2009 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal SMAD5 Primary Antibody for ICC, FACS - ABIN969404 : Chang, Chang, Lee, Lee, Yeh, Yeh, Cheng, Chien, Chiu: Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 2 Pubmed References

更多抗SMAD5的相互作用对抗体

Human SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. We demonstrated high expression of miR-145 associated with late stage and unfavorable prognosis of esophageal cancer. We identified SMAD5 as direct target of miR-145, the suppressed expression of which consequently led to increased cell proliferation and migration/invasion.

  2. Smad5 acts as a intracellular pH messenger and maintains the bioenergetic homeostasis of cells by regulating cytoplasmic metabolic machinery.

  3. Differential expression of TGF-beta superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.

  4. Data suggest that differences in expression levels in granulosa-like tumor cells and granulosa cells (GCs) from patients with polycystic ovary syndrome (PCOS) are due to increased expression of microRNA-27a-3p in GCs caused by insulin resistance in PCOS; microRNA-27a-3 expression is up-regulated in GCs in PCOS; overexpression of miR-27a-3p inhibits SMAD5 expression and promotes apoptosis. (SMAD5 = SMAD family member 5)

  5. Here the involvement of the pathway in adult brain function is suggested. This exploratory study establishes a strategy to better identify neuronal molecular signatures that are potentially associated with mental illness and cognitive deficits. We propose that the SMAD pathway may be a novel target in addressing cognitive deficit of SZ in future studies.

  6. the BMP-2/Smad1/5/RUNX2 signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin synth

  7. miR-23a and miR-27a target SMAD5 and regulate apoptosis in human granulosa cells via the FasL-Fas pathway

  8. Our findings suggest that suppression of miR-222-3p activity promoted osteogenic differentiation hBMSCs through regulating Smad5-RUNX2 signaling axis.

  9. Overexpression of the BMP4/SMAD4/SMAD5 signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis.

  10. The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.

  11. adult human Sertoli cells assumed similar morphological features, stable global gene expression profiles and numerous proteins, and activation of AKT and SMAD1/5 during long-period culture.

  12. balance between Smad1/5- and Smad2/3-dependent signaling defines the outcome of the effect of TGF-beta on atherosclerosis where Smad1/5 is responsible for proatherogenic effects

  13. among the 15 SNPs, rs3206634 was significantly associated with KD in a recessive model (odds ratio = 2.31, p = 0.019), whereas there was no association between any of the 15 SNPs and CALs.

  14. Our results indicated that KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4/smad5 pathway.

  15. Inhibiting Smurf1 mediated ubiquitination of Smad1/5.

  16. Specific gene siRNAs knock-down further confirmed the osteogenic effects of Genistein on BMP2, SMAD5 and RUNX2 protein expression

  17. Results indicate that BMP/Smad signaling pathway was altered during the period of osteogenesis, and that the activities of p-Smad1/5 were required for Saos-2 cells viability and differentiation induced by fluoride.

  18. the shear-induced apoptosis and autophagy are mediated by bone morphogenetic protein receptor type (BMPR)-IB, BMPR-specific Smad1 and Smad5, and p38 mitogen-activated protein kinase.

  19. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7.

  20. our studies establish that loss of SMAD1/5 leads to upregulation of PDGFA in ovarian granulosa cells

Zebrafish SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway.

  2. Alk3 and Alk3b, as well as SMAD5, are essential cellular mediators of BMP signaling in zebrfish.

  3. Data show that interplay of Smad1/5 and MAP kinase signaling system (ERK signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.

  4. this study uncovers that smad1 and smad9 act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis.

  5. Functional investigation of a subset of these genes, fgf10a, tgfb2, pax9, and smad5 revealed their necessity in zebrafish palatogenesis.

  6. maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2/7 signaling to establish the initial dorsoventral asymmetry

  7. Data show that patterning of the eye primordia in Smad5-deficient embryos starts during blastula and early gastrula stages.

  8. that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 and Smad5.

  9. Data show that Smad5 expression is ubiquitous during testis development but becomes cell-specific in the adult.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. SMAD5 is crucial for expanding amniotic ectoderm rapidly into a stretchable squamous sheet to accommodate exocoelom expansion, axial growth and folding morphogenesis.

  2. CD137 signaling is a new regulator of angiogenesis by modulating the Smad1/5-NFATc1 pathway.

  3. miR-155 inhibited osteoblast differentiation by downregulating the translation of SMAD5 in mouse preosteoblast cells. Inhibition of miR-155 promoted osteogenic potential and thus it can be used as a potential target in the treatment of bone defects.

  4. Up-regulation of miR-93 may contribute to the progression of morphine tolerance by targeting Smad5 in mouse model of bone cancer pain

  5. Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2) expression through S1PR2/RhoA/ROCK/Smad1/5/8 signaling.

  6. We discovered that Smad1/5/4-Amhr2-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1/5/4-Amhr2-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.

  7. these studies characterize an accessory TGF-beta-stimulated BMP R-Smad signaling mechanism in interstitial cells of the developing lung.

  8. Thyroid-specific Smad1 and Smad5 double-knockout (Smad1/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.

  9. Smad1 and Smad5 have overlapping functions to govern hepcidin transcription. Moreover, erythropoietin and erythroferrone target Smad1/5 signaling and require Smad1/5 to suppress hepcidin expression.

  10. miR-106b-5p and miR-17-5p are novel Smad5 regulators.

  11. BetA can enhance in vivo osteogenic potentials of BMP2, possibly via stimulating Smad 1/5/8 and p38 pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases.

  12. Data show that in R-Smad proteins Smad1;Smad5 knockout embryonic stem cells (mESCs), the bone morphogenetic proteins (BMP)-SMAD signaling is dispensable for self-renewal.

  13. Data show that R-Smad Proteins SMAD1 and SMAD5, which transduce bone morphogenetic protein (BMP) signals, recognize enhancer regions together with Kruppel-like factors KLF4 and KLF5 in naive embryonic stem cell (mESCs).

  14. The crystal structure of Smad5-MH1 domain in complex with a composite DNA sequence demonstrates that the MH1 domain is targeted to a binding site with modular binding modes, and the length of the DNA spacer affects the MH1 assembly.

  15. The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2/Smad1/5/8 and Wnt/beta-catenin pathways.

  16. FLI1 and GATA2 are upstream regulators of SMAD1 and SMAD5 expression in endothelial cells.

  17. Data indicate that PDGF-AA promotes mesenchymal stem cel migration via bone morphogenetic protein 2 (BMP2)-smad proteins smad1/5/8 activation requires lysosome-mediated degradation of PDGF alpha Receptor (PDGFRalpha).

  18. some pSMAD1/5 targets, like Gata3, function specifically in transit amplifying cell lineage-progression.

  19. The effects of a soy-free diet on the risk of granulosa cell tumors in mice with conditional double knockout of Smad1 and Smad5 are reported.

  20. our data suggest a pivotal role for canonical BMP signaling demonstrating distinguished nonoverlapping function of pSmad8 with pSmad1 and pSmad5 in hfSCs regulation and hair morphogenesis but a redundant role in adult hair progenitors differentiation.

SMAD5 抗原简介

蛋白简介

The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with SMAD5

  • SMAD family member 5 (SMAD5) 抗体
  • SMAD family member 5 (Smad5) 抗体
  • SMAD family member 5 (smad5) 抗体
  • 1110051M15Rik 抗体
  • AI451355 抗体
  • DKFZp468M0619 抗体
  • Dwf-C 抗体
  • DWFC 抗体
  • fb67b04 抗体
  • JV5-1 抗体
  • mad 抗体
  • madh5 抗体
  • MusMLP 抗体
  • sb:cb400 抗体
  • SBN 抗体
  • SMAD5 抗体
  • smd5 抗体
  • wu:fb67b04 抗体

Protein level used designations for SMAD5

MAD, mothers against decapentaplegic homolog 5 , SMA- and MAD-related protein 5 , SMAD, mothers against DPP homolog 5 , mothers against decapentaplegic homolog 5 , mothers against decapentaplegic, drosophila, homolog of, 5 , MAD homolog 5 , SMAD 5 , mothers against DPP homolog 5 , SMAD family member 5 , pgy , piggytail , somitabun , Mothers against decapentaplegic homolog 5 , Smad 5 , dwarfin-C , mSmad5

GENE ID SPECIES
4090 Homo sapiens
59328 Rattus norvegicus
395679 Gallus gallus
30641 Danio rerio
481520 Canis lupus familiaris
768050 Bos taurus
100033851 Equus caballus
100173534 Pongo abelii
100303615 Sus scrofa
17129 Mus musculus
100717571 Cavia porcellus
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