anti-Runt-Related Transcription Factor 3 (RUNX3) 抗体

RUNX3 encodes a member of the runt domain-containing family of transcription factors. 再加上,我们可以发RUNX3 蛋白 (12)RUNX3 试剂盒 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
RUNX3 12399  
RUNX3 864 Q13761
RUNX3 156726  
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Showing 10 out of 199 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 IHC (p), WB Anti- RUNX3 Picoband antibody, IHC(P) IHC(P): Rat Spleen Tissue Anti- RUNX3 Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 4至6个工作日
小鼠 非结合性 ELISA, FACS, ICC, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using RUNX3 mAb against human RUNX3 recombinant protein. (Expected MW is 33 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8至11个工作日
Cow 非结合性 WB WB Suggested Anti-RUNX3 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:12500  Positive Control:  NIH/3T3 cell lysate 100 μL Log in to see 2至3个工作日
小鸡 非结合性 WB Western blot analysis of RUNX3 expression in Jurkat (A), Raji (B), SW480 (C) whole cell lysates. 200 μL Log in to see 13至14个工作日
小鼠 非结合性 CyTOF, FACS, ICC, SimWes, WB Detection of Human RUNX3/CBFA3 by Simple WesternTM. Simple Western lane view shows lysates of Jurkat human acute T cell leukemia cell line and Daudi human Burkitt's lymphoma cell line, loaded at 0.5 mg/mL. A specific band was detected for RUNX3/CBFA3 at approximately 54 kDa (as indicated) using 10 ug/mL of Mouse Anti-Human/Mouse RUNX3/CBFA3 Monoclonal Antibody. This experiment was conducted under reducing conditions and using the 12-230 kDa separation system. Detection of RUNX3/CBFA3 in Human PBMC by Flow Cytometry. Human PBMC unstimulated (light orange filled histogram) or treated with 50ng/mL PMA (dark orange filled histogram) were stained with Mouse Anti-Human/Mouse RUNX3/CBFA3 Monoclonal Antibody. To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. 100 μg Log in to see 8至9个工作日
非结合性 ELISA, WB 100 μL Log in to see Available
小鼠 非结合性 ELISA, FACS, IF/ICC, IHC, WB 100 μg Log in to see 11至16个工作日
Cow 非结合性 WB 100 μL Log in to see 11至14个工作日
非结合性 ELISA, ICC, IF, WB ABIN6268736 staining 293 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. Western blot analysis of RUNX3 expression in HUVEC cells 100 μL Log in to see 11至12个工作日
小鼠 非结合性 IF, IHC (p), WB Western Blot analysis of RUNX3 expression in transfected 293T cell line by RUNX3 MaxPab polyclonal antibody.Lane 1: RUNX3 transfected lysate(47.19 KDa).Lane 2: Non-transfected lysate. RUNX3 MaxPab polyclonal antibody. Western Blot analysis of RUNX3 expression in human pancreas. 50 μL Log in to see 11至12个工作日

引用最多的anti-RUNX3 抗体

  1. Human Monoclonal RUNX3 Primary Antibody for ICS, IHC (p) - ABIN2689899 : Chuang, Ito, Ito: RUNX family: Regulation and diversification of roles through interacting proteins. in International journal of cancer. Journal international du cancer 2013 (PubMed)
    Show all 6 Pubmed References

  2. Human Polyclonal RUNX3 Primary Antibody for EMSA - ABIN3434042 : Peng, Wei, Wang, Tang, Zhang, Le, Jia, Li, Xie: RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006 (PubMed)
    Show all 6 Pubmed References

  3. Human Polyclonal RUNX3 Primary Antibody for ELISA, WB - ABIN560191 : Nakamura, Senzaki, Yoshikawa, Nishimura, Inoue, Ito, Ozaki, Shiga: Dynamic regulation of the expression of neurotrophin receptors by Runx3. in Development (Cambridge, England) 2008 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal RUNX3 Primary Antibody for CyTOF, FACS - ABIN4899364 : Chopin, Seillet, Chevrier, Wu, Wang, Morse, Belz, Nutt: Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks. in The Journal of experimental medicine 2013 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal RUNX3 Primary Antibody for ICC, FACS - ABIN1724742 : Mei, Bai, Liu, Li, Wu, Yu, Zheng: RUNX3 expression is lost in glioma and its restoration causes drastic suppression of tumor invasion and migration. in Journal of cancer research and clinical oncology 2011 (PubMed)

  6. Human Polyclonal RUNX3 Primary Antibody for WB - ABIN6713267 : Wang, Li, Yu, Su, Li, Ju, Yu, Gu, Zhu, Liu: Overexpressed miR-301a promotes cell proliferation and invasion by targeting RUNX3 in gastric cancer. in Journal of gastroenterology 2014 (PubMed)

  7. Human Polyclonal RUNX3 Primary Antibody for IF, IHC (p) - ABIN514065 : Shi, Wang, Liu, Chen: Inactivation of RUNX3 predicts poor prognosis in esophageal squamous cell carcinoma after Ivor-Lewis esophagectomy. in Medical oncology (Northwood, London, England) 2014 (PubMed)

  8. Human Polyclonal RUNX3 Primary Antibody for ELISA, ICC - ABIN6264885 : Li, Zhao, Huang, Wang, Zhu, Cao, Xiong, Deng: MiR-93-5p promotes gastric cancer-cell progression via inactivation of the Hippo signaling pathway. in Gene 2017 (PubMed)


Zebrafish Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. In neuronal fate determination, Runx co-factor Cbfbeta is essential for its function, but the high level of Runx3 expression can overcome the loss of Cbfbeta, demonstrating that Cbfbeta in this context serves solely as a signal amplifier of Runx3 activity.

  2. successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish

  3. isolation and characterization by spatiotemporal expression detected in the developing zebrafish

  4. Runx3 expression leads to an increase in primitive blood cell numbers, together with an increase in runx1-expressing cells in the ventral wall of the dorsal aorta.

  5. Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 and lose hematopoietic runx1 expression in early embryonic development.

Pig (Porcine) Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. These results demonstrate that the CRISPR/Cas9 system is effective in inducing mutations on a specific locus of genome and the RUNX3 knockout pigs can be useful resources for human cancer research and to develop novel cancer therapies.

Mouse (Murine) Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. Runx3 governs chromatin accessibility during T cell receptor stimulation and enforces the memory cytotoxic T lymphocyte developmental program.

  2. The promoter regions of Runx3 is targets of STAT4 and that STAT4 binding during NK cell activation induces epigenetic modifications of Runx3 gene loci resulting in increased expression.

  3. Runx3 programs CD8(+) T cell residency in non-lymphoid tissues and tumours; results provide insight into the signals that promote T cell residency in non-lymphoid sites, which could be used to enhance vaccine efficacy or adoptive cell therapy treatments that target cancer

  4. Findings suggest that Runx3 may regulate cell shape to inhibit melanoma cell migration partly through enhancing stress fiber formation and ECM protein production.

  5. The findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.

  6. Runx3-deficient CD8(+) cytotoxic effector T cells aberrantly upregulated genes characteristic of follicular helper T (TFH) cell lineage, including Bcl6, Tcf7 and Cxcr5. Mechanistically, the Runx3-CBFbeta transcription factor complex deployed H3K27me3 to Bcl6 and Tcf7 genes to suppress the TFH program.

  7. Deletion of Runx3 in the peripheral nervous system or specifically in peripheral sensory neurons, or of enhancer elements driving Runx3 expression in proprioceptive neurons, induced prepubertal scoliosis.

  8. We found that Runx3 exerted a positive effect on early myeloid development

  9. Runx3 plays a crucial role in the hypothalamo-pituitary-gonadal axis

  10. intricate combinatorial interplay among the three regulatory elements governs Runx3 expression in distinct subtypes of TrkC neurons while concomitantly extinguishing its expression in non-TrkC neurons

  11. this study identifies a compensatory signaling mechanism that prevents lineage-fate errors by dynamically modulating Runx3d induction rates during MHC I positive selection

  12. our data suggest that Runx3 may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 variants

  13. Runx3 is crucial for the phenotypic and functional changes observed in ThPok-deficient invariant natural killer T cells.

  14. the transcription factor Runx3 was essential for the normal development of subsets of innate lymphoid cells (ILCs) in the mucosa

  15. Runx1 and Runx3 are the downstream effectors of Nanog, especially in the early and intermediate osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2.

  16. nonpermissive expression of RUNX3 protein is restricted at the translational level, and that the repression is further enforced by a transcriptional regulation for maintenance of diverse developmental plasticity of T cells for different effector subsets.

  17. Our findings establish Nr4a1 as a novel and critical player in the regulation of CD8 T cell development through the direct suppression of Runx3.

  18. Runx1 Runx3 DKO mice exhibit bone marrow failure and myeloproliferative disorder. RUNX proteins are important for FANCD2 recruitment to DNA repair foci.

  19. inflammation-mediated tumor promotion requires leukocytic Runx3 expression

  20. Bone histomorphometry revealed that decreased osteoblast numbers and reduced mineral deposition capacity in Runx3-deficient mice cause this bone formation deficiency.

Human Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the cell cycle restriction point.

  2. HP plays an important role in the development and progression of GC through silencing of CDH1, RUNX3, p21WAF and p27 expression

  3. The present study suggested a genetic association between RUNX3 gene polymorphisms and severe preeclampsia

  4. The Runx3 may regulate the development of T cell lineage including those of innate lymphoid cells, Treg cells and dendritic cells, which may contribute to the development of hypersensitivity and asthma.

  5. Runx3 ubiquitination is regulated by HOTAIR in the gastric cancer.HOTAIR is negatively associated with Runx3 in gastric cancer tissues.

  6. RUNX3 creates an effective barrier against further TGFbeta-dependent tumor progression by preventing genomic instability.

  7. Therefore miR199b may serve as an oncogene in Wilms' tumour (WT)progression by directly targeting RUNX3, thereby suggesting that the miR199b/RUNX3 axis may be a promising therapeutic target for patients with WT

  8. High expression of miR-20a-5p significantly decreased both the mRNA and protein levels of RUNX3, as well as its direct downstream targets Bim and p21.

  9. The present results suggested that methylation may serve a critical role in the silencing of RUNX3 and loss of RUNX3 expression may serve as a prognostic marker in endometrial cancer.

  10. RUNX3 expression correlates with tumor's differentiation, depth of invasion, lymph node metastasis, distant metastasis, TNM stage and overall survival of gastric cancer patients.

  11. MiR-182/HOXA9 was involved in the process of RUNX3-mediated GC tumor growth.

  12. The BMP9-induced phosphorylation of Smad1/5/8 was increased with the overexpression of RUNX3, and yet was decreased with the knockdown of RUNX3. Collectively, our findings suggest that RUNX3 is an essential modulator of the BMP9-induced osteoblast lineage differentiation of mesenchymal stem cells (MSCs).

  13. results suggest that EZH2 regulates cell proliferation potentially by targeting RUNX3 through the Wnt/beta-catenin signaling pathway in laryngeal carcinoma.

  14. These findings suggested that RUNX3 played a tumor suppressor role in oral squamous cell carcinoma (OSCC) by inhibiting cell migration, invasion and angiogenesis, supporting that it could be a potential therapeutic target for OSCC

  15. Study showed that Runx3 was found a target of miR-106b, and the inhibition of miR-106b upregulated Runx3. These results provide evidence that Runx3 is a tumor-suppressor in retinoblastoma and is a target of miR-106b.

  16. Our results support the ability of Runx3 to contribute to the dissemination of human PDAC thus confirming the observations from murine models.

  17. High expression of RUNX3 is correlated with gastric cancer.

  18. RUNX3 is a common downstream target of TGF-beta and Notch signaling, and may be a novel therapeutic target for treating CVD mediated by EndMT.

  19. CNRIP1 and RUNX3 as potential DNA methylation biomarkers for CRC diagnosis and treatment

  20. RUNX3 expression in oral squamous carcinoma cells contributes to their bone invasion and the resulting osteolysis by inducing their malignant behaviors and production of osteolytic factors.

RUNX3 抗原简介


This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX3

  • runt-related transcription factor 3 (runx3) 抗体
  • runt-related transcription factor 3 (RUNX3) 抗体
  • runt related transcription factor 3 (RUNX3) 抗体
  • runt related transcription factor 3 (runx3) 抗体
  • runt related transcription factor 3 L homeolog (runx3.L) 抗体
  • runt related transcription factor 3 (Runx3) 抗体
  • runt-related transcription factor 3 (Runx3) 抗体
  • AML2 抗体
  • Cbfa3 抗体
  • frrunx3 抗体
  • Pebp2a3 抗体
  • PEBP2aC 抗体
  • runx3 抗体
  • runxb 抗体

Protein level used designations for RUNX3

runt-related transcription factor b , runt-related transcription factor 3 , core-binding factor 3 , frRunx3/p45 , CBF-alpha-3 , PEA2-alpha C , PEBP2-alpha C , SL3-3 enhancer factor 1 alpha C subunit , SL3/AKV core-binding factor alpha C subunit , acute myeloid leukemia 2 protein , core binding factor alpha 3 , core-binding factor subunit alpha-3 , oncogene AML-2 , polyomavirus enhancer-binding protein 2 alpha C subunit , runt domain, alpha subunit 3 , transcription factor AML2/CBFA3 , PEA2 alpha C , PEBP2 alpha C , acute myeloid leukemia gene 2 , core-binding factor, runt domain, alpha subunit 3 , transcription factor AML2 , Runt related transcription factor 3 , Runx3 MASN-variant

58127 Danio rerio
403159 Sus scrofa
456633 Pan troglodytes
100049632 Takifugu rubripes
100474431 Ailuropoda melanoleuca
100500732 Xenopus laevis
12399 Mus musculus
864 Homo sapiens
617389 Bos taurus
156726 Rattus norvegicus
769687 Gallus gallus
487366 Canis lupus familiaris
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