anti-Runt-Related Transcription Factor 1 (RUNX1) 抗体

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters.

列出全部抗体 基因 基因ID UniProt
抗小鼠 RUNX1 RUNX1 12394 Q03347
抗人 RUNX1 RUNX1 861 Q01196
抗大鼠 RUNX1 RUNX1 50662 Q63046
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antibodies-online.cn销售最多的anti-RUNX1 抗体

Showing 10 out of 311 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
人 兔 非结合性 WB AML-1/Runx1 antibody tested by Western blot. Detection of AML-1/Runx1 by Western blot analysis. Positive detection of AML-1/Runx1 in nuclear extracts derived from Jurkat cells at 1:500 (lane 1) and 1:1,000 (lane 2) dilutions. 100 μL Log in to see 1至2个工作日
$495.83
详细
Cow 兔 非结合性 IHC, WB Sample Type : Mouse, post-natal day (p) 0 retinal ganglion cells Primary Antibody Dilution : 1:1500 Secondary Antibody : Donkey anti rabbit IgG Alexa 594 Secondary Antibody Dilution : 1:1000 Gene Name : RUNX1 Submitted by : Anonymous WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: PANC1 cell lysate There is BioGPS gene expression data showing that RUNX1 is expressed in PANC1 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 兔 非结合性 WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Jurkat cell lysate RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells WB Suggested Anti-RUNX1 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 <br /> Positive Control: Jurkat cell lysate <br /> RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 兔 非结合性 WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Jurkat cell lysate RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells WB Suggested Anti-RUNX1 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500 <br /> Positive Control: Jurkat cell lysate <br /> RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 兔 非结合性 WB Host: Rabbit Target Name: Runx1 Sample Type: Mouse Skeletal Muscle lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 兔 非结合性 WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: 721_B cell lysate RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 兔 非结合性 WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:7812500 Positive Control: Human Small Intestine 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 兔 非结合性 IHC, WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: SH-SYSY cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
人 兔 非结合性 IHC (p), WB Anti-RUNX1/AML1 Picoband antibody , All lanes: Anti RUNX1 at 0.5ug/ml WB: Recombinant Human RUNX1 Protein 0.5ng Predicted bind size: 50KD Observed bind size: 50KD Anti-RUNX1/AML1 Picoband antibody , IHC(P): Mouse Intestine Tissue 100 μg Log in to see 4至6个工作日
$280.00
详细
小鸡 兔 非结合性 IC, IF, IHC, WB Immunofluorescent analysis of RUNX1 staining in THP1 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of RUNX1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13至14个工作日
$487.50
详细

引用最多的anti-RUNX1 抗体

  1. Human Polyclonal RUNX1 Primary Antibody for WB - ABIN2668716 : Zaidi, Dowdy, van Wijnen, Lian, Raza, Stein, Croce, Stein: Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network. in Cancer research 2009 (PubMed)
    Show all 19 Pubmed References

  2. Human Monoclonal RUNX1 Primary Antibody for ELISA, WB - ABIN969390 : Marshall, Moore, Ohki, Kitabayashi, Patterson, Ornelles: RUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis. in Journal of virology 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal RUNX1 Primary Antibody for IF, IHC (p) - ABIN514054 : Hussein, Dralle, Theophile, Kreipe, Bock: Megakaryocytic expression of miRNA 10a, 17-5p, 20a and 126 in Philadelphia chromosome-negative myeloproliferative neoplasm. in Annals of hematology 2009 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal RUNX1 Primary Antibody for WB - ABIN537342 : Srivastava, Srivastava: Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. in Leukemia research 2005 (PubMed)
    Show all 2 Pubmed References

  5. Human Monoclonal RUNX1 Primary Antibody for ICC, ELISA - ABIN969389 : Zharlyganova, Harada, Harada, Shinkarev, Zhumadilov, Zhunusova, Tchaizhunusova, Apsalikov, Kemaikin, Zhumadilov, Kawano, Kimura, Hoshi: High frequency of AML1/RUNX1 point mutations in radiation-associated myelodysplastic syndrome around Semipalatinsk nuclear test site. in Journal of radiation research 2008 (PubMed)

  6. Human Monoclonal RUNX1 Primary Antibody for IF, IHC (p) - ABIN514053 : Keita, Bachvarova, Morin, Plante, Gregoire, Renaud, Sebastianelli, Trinh, Bachvarov: The RUNX1 transcription factor is expressed in serous epithelial ovarian carcinoma and contributes to cell proliferation, migration and invasion. in Cell cycle (Georgetown, Tex.) 2013 (PubMed)

  7. Cow (Bovine) Polyclonal RUNX1 Primary Antibody for IHC, WB - ABIN2777187 : Takeshita, Ichikawa, Nitta, Goyama, Asai, Ogawa, Chiba, Kurokawa: AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. in Leukemia 2008 (PubMed)

  8. Human Monoclonal RUNX1 Primary Antibody for ELISA, WB - ABIN966980 : Ichikawa, Goyama, Asai, Kawazu, Nakagawa, Takeshita, Chiba, Ogawa, Kurokawa: AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis. in Journal of immunology (Baltimore, Md. : 1950) 2008 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal RUNX1 Primary Antibody for IF, IHC (p) - ABIN2476393 : Tsou, Ransom, Gerlt, Powers, Kenyon: Selection and characterization of a mutant of the cloned gene for mandelate racemase that confers resistance to an affinity label by greatly enhanced production of enzyme. in Biochemistry 1989 (PubMed)
    Show all 2 Pubmed References

  10. Human Polyclonal RUNX1 Primary Antibody for WB - ABIN2801939 : Miyoshi, Shimizu, Kozu, Maseki, Kaneko, Ohki: t(8,21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1. in Proceedings of the National Academy of Sciences of the United States of America 1992 (PubMed)
    Show all 4 Pubmed References

更多抗RUNX1的相互作用对抗体

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Results suggest that AML1/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  2. Gene expression profiling of HEPs revealed a RUNX1c-induced proinflammatory molecular signature, supporting previous studies demonstrating proinflammatory signaling as a regulator of HSC (显示 FUT1 抗体) emergence.

  3. Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 (显示 NFE2 抗体) and either RUNX1, FLI1 (显示 FLI1 抗体) or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.

  4. the ability of Runx1 to induce endothelial-to-hematopoietic transition (EHT (显示 CBFA2T2 抗体)) in non-hemogenic endothelial cells depends on the anatomical location of the cell and the developmental age of the conceptus

  5. CDK6 (显示 CDK6 抗体) kinase activity negatively regulates the conversion of fat-storing cells into fat-burning cells by suppressing RUNX1, and may be a therapeutic target for the treatment of obesity and related metabolic diseases

  6. RUNX1 dosage plays a pivotal role in hemogenic endothelium maturation and the establishment of the hematopoietic system.

  7. These results suggest that RUNX1 may be an essential modulator in BMP9 (显示 GDF2 抗体)- induced osteogenic differentiation of mesenchymal stem cells.

  8. Loss of Runx1 and Runx2 (显示 RUNX2 抗体) inhibits prostate cell motility.

  9. In vivo, in vitro and systems biology results show that Runx1 exerts a pro-neurogenic function in neural precursor cells in vitro, while in vivo data remained inconclusive.

  10. High RUNX1 expression is associated with lymphoma.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our findings show the profound impact of RUNX1 allele dosage on gene expression profile and glucocorticoid sensitivity in AML, thereby opening opportunities for preclinical testing which may lead to drug repurposing and improved disease characterization.

  2. This study established inducible RUNX1b/c-overexpressing human embryonic stem cell (hESC) lines, in which RUNX1b/c overexpression prevented the emergence of CD34 (显示 CD34 抗体)+ cells from early stage, thereby drastically reducing the production of hematopoietic stem/progenitor cells. Simultaneously, the expression of hematopoiesis-related factors was downregulated.

  3. Genome-engineered hPSCs expressing ETV6 (显示 ETV6 抗体)-RUNX1 from the endogenous ETV6 (显示 ETV6 抗体) locus show expansion of the CD19 (显示 CD19 抗体)(-)IL-7R(+) compartment

  4. our study demonstrated that specific bone marrow abnormalities and acquired genetic alterations may be harbingers of progression to hematological malignancies in patients with familial platelet disorder with germline RUNX1 mutation.

  5. These studies provide the first evidence in patients with a RUNX1 mutation for a defect in AH (lysosomal) secretion, and for a global defect in secretion involving all three types of platelet granules that is unrelated to a granule content deficiency. They highlight the pleiotropic effects and multiple platelet defects associated with RUNX1 mutations.

  6. Younger mRUNX1 AML patients treated with intensive chemotherapy experienced inferior treatment outcomes. In older patients with AML treated with hypomethylating agent (HMA) therapy, response and survival was independent of RUNX1 status. Older mRUNX1 patients with prior myelodysplastic syndrome or myeloproliferative neoplasms (MDS (显示 PAFAH1B1 抗体)/MPN (显示 PRSS27 抗体)) had particularly dismal outcome

  7. Data indicate miR (显示 MLXIP 抗体)-29b-1 as a regulator of the AML1-ETO protein (RUNX1-RUNX1T1), and that miR (显示 MLXIP 抗体)-29b-1 expression in t(8;21)-carrying leukemic cell lines partially rescues the leukemic phenotype.

  8. EBPA and RUNX1 are expressed at higher levels in patients with acute myeloid leukemia (显示 BCL11A 抗体) in comparison to healthy subjects

  9. The first characterization of this CASC15 in RUNX1-translocated leukemia.

  10. Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1-ETO/THAP10 (显示 THAP10 抗体)/miR (显示 MLXIP 抗体)-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 (显示 THAP10 抗体) predicts a poor clinical outcome and represents a novel therapeutic target.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (显示 CTCF 抗体) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (显示 MYEF2 抗体) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (显示 RAD21 抗体), or cohesin subunit Smc3 (显示 SMC3 抗体), fail to express runx3 (显示 RUNX3 抗体) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (显示 RUNX2 抗体) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 抗原简介

蛋白简介

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • uncharacterized LOC473981 (LOC473981) 抗体
  • runt-related transcription factor (runt) 抗体
  • runt related transcription factor 1 (Runx1) 抗体
  • runt related transcription factor 1 (RUNX1) 抗体
  • runt-related transcription factor 1 (runx1) 抗体
  • runt related transcription factor 1 L homeolog (runx1.L) 抗体
  • runt-related transcription factor 1 (RUNX1) 抗体
  • runt-related transcription factor 1 (Runx1) 抗体
  • AI462102 抗体
  • aml 抗体
  • aml-1 抗体
  • Aml1 抗体
  • aml1-evi-1 抗体
  • amlcr1 抗体
  • cbfa2 抗体
  • evi-1 抗体
  • Pebp2a2 抗体
  • pebp2ab 抗体
  • Pebpa2b 抗体
  • Runx-1 抗体
  • runx1 抗体
  • runxa 抗体
  • XAML 抗体
  • Xaml1 抗体

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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