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RUNX1 抗体 (AA 221-480)

Name: RUNX1 抗体 (AA 221-480)
Brand: antibodies-online
SKU: ABIN6147309
Availability: OutOfStock

RUNX1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts of various cell lines, using RUNX1 antibody (ABIN6129946, ABIN6147309, ABIN6147311 and ABIN6213835) at 1:1000 dilution.

Identification of RUNX1 as an apoptosis transcription factor and an independent prognostic factor in NB tissue and cell lines.

RUNX1 suppresses the growth, migration, invasion and angiogenesis of NB cells in vitro.

Overexpression of RUNX1 promoted NB cell apoptosis, and knockdown of RUNX1 led to suppression of NB apoptosis.

RUNX1 promoted apoptosis in NB cells and altered the transcription and protein levels of BIRC5, CSF2RB, and NFKBIA.

RUNX1 altered the transcription and protein levels of BIRC5, CSF2RB, and NFKBIA through direct binding of its promoter.

ChIP

Ectopic expression of RUNX1 suppresses NB cell growth, metastasis, and angiogenesis and promotes apoptosis in vivo.

Cisplatin promoted apoptosis by promoting RUNX1 expression in NB cells.

9 images

产品编号 ABIN6147309

发货至: 中国

Datasheet as PDF

抗原 See all RUNX1 抗体

RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))
抗原表位
26

16

14

13

11

11

10

7

6

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 221-480
适用
165

104

67

13

10

10

10

9

7

5

5

4

1

1

1

1

1
人
宿主
162

15

2

1
兔
Compatible Secondaries
克隆类型
164

17
多克隆
标记
102

11

7

7

7

7

7

7

6

5

3

2

2

2

2

2

2
This RUNX1 antibody is un-conjugated
应用范围
136

80

47

37

31

23

15

13

13

6

4

3

1

1

1

1

1

1
Western Blotting (WB)

序列

FSERLSELEQ LRRTAMRVSP HHPAPTPNPR ASLNHSTAFN PQPQSQMQDT RQIQPSPPWS YDQSYQYLGS IASPSVHPAT PISPGRASGM TTLSAELSSR LSTAPDLTAF SDPRQFPALP SISDPRMHYP GAFTYSPTPV TSGIGIGMSA MGSATRYHTY LPPPYPGSSQ AQGGPFQASS PSYHLYYGAS AGSYQFSMVG GERSPPRILP PCTNASTGSA LLNPSLPNQS DVVEAEGSHS NSPTNMAPSA RLEEAVWRPY

交叉反应

人, 小鼠, 大鼠

产品特性

Polyclonal Antibodies

免疫原

Recombinant fusion protein containing a sequence corresponding to amino acids 221-480 of human RUNX1 (NP_001745.2).

亚型

IgG

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Discover our top product RUNX1 Primary Antibody
anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 210-310) antibody
RUNX1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2C10 unconjugated

anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 150-250) antibody
RUNX1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Runt-Related Transcription Factor 1 (RUNX1) antibody
RUNX1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 210-310) antibody
RUNX1 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 3A1 unconjugated

anti-Runt-Related Transcription Factor 1 (RUNX1) (pSer304) antibody
RUNX1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 227-255) antibody
RUNX1 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 237-337) antibody
RUNX1 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 6C12A5 unconjugated

anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 200-233), (Middle Region) antibody
RUNX1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Runt-Related Transcription Factor 1 (RUNX1) (AA 227-255) antibody
RUNX1 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB15210 unconjugated

anti-Runt-Related Transcription Factor 1 (RUNX1) (Middle Region) antibody
RUNX1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB,1:500 - 1:2000

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20°C. Avoid freeze / thaw cycles.
抗原

RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))

别名

RUNX1 (RUNX1 产品)

别名

RUNX1 antibody, runx1 antibody, AI462102 antibody, AML1 antibody, Cbfa2 antibody, Pebp2a2 antibody, Pebpa2b antibody, AML1-EVI-1 antibody, AMLCR1 antibody, CBFA2 antibody, EVI-1 antibody, PEBP2aB antibody, runxa antibody, Runx-1 antibody, XAML antibody, Xaml1 antibody, aml antibody, aml-1 antibody, aml1 antibody, aml1-evi-1 antibody, amlcr1 antibody, cbfa2 antibody, evi-1 antibody, pebp2ab antibody, Aml1 antibody, uncharacterized LOC473981 antibody, runt-related transcription factor antibody, runt related transcription factor 1 antibody, runt-related transcription factor 1 antibody, runt related transcription factor 1 L homeolog antibody, LOC473981 antibody, runt antibody, Runx1 antibody, RUNX1 antibody, runx1 antibody, runx1.L antibody

背景

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.,RUNX1,AML1,AML1-EVI-1,AMLCR1,CBF2alpha,CBFA2,EVI-1,PEBP2aB,PEBP2alpha,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Cell Biology & Developmental Biology,Hippo Signaling Pathway,Neuroscience,Stem Cells,Hematopoietic Progenitors,Cardiovascular,Angiogenesis,RUNX1

分子量

20-28 kDa/37 kDa/48-51 kDa

基因ID

861

UniProt

Q01196