Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) ELISA试剂盒

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. 再加上,我们可以发RUNX1T1 抗体 (51)RUNX1T1 蛋白 (6)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
大鼠 RUNX1T1 RUNX1T1 362489  
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< 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Log in to see 11至18个工作日
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适于 RUNX1T1 相互作用对的更多 ELISA 试剂盒

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. PKM2 (显示 PKM ELISA试剂盒) as a novel target of RUNX1 (显示 RUNX1 ELISA试剂盒)-ETO and is specifically downregulated in RUNX1 (显示 RUNX1 ELISA试剂盒)-ETO positive AML (显示 RUNX1 ELISA试剂盒) patients, indicating that PKM2 (显示 PKM ELISA试剂盒) level might have a diagnostic potential in RUNX1 (显示 RUNX1 ELISA试剂盒)-ETO associated AML (显示 RUNX1 ELISA试剂盒).

  2. The specific association of ZBTB7A (显示 ZBTB7A ELISA试剂盒) mutations with t(8;21) rearranged acute myeloid leukaemia points towards leukemogenic cooperativity between mutant ZBTB7A (显示 ZBTB7A ELISA试剂盒) and the RUNX1 (显示 RUNX1 ELISA试剂盒)/RUNX1T1 fusion protein has been reported.

  3. Data indicate miR-29b-1 as a regulator of the AML1-ETO protein (RUNX1-RUNX1T1), and that miR-29b-1 expression in t(8;21)-carrying leukemic cell lines partially rescues the leukemic phenotype.

  4. Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1-ETO/THAP10/miR-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 predicts a poor clinical outcome and represents a novel therapeutic target.

  5. RUNX1 (显示 RUNX1 ELISA试剂盒)-RUNX1T1 transcript levels were measured in bone marrow samples collected from 208 patients at scheduled time points after transplantation. Over 90% of the 175 patients who were in continuous complete remission had a >/=3-log reduction in RUNX1 (显示 RUNX1 ELISA试剂盒)-RUNX1T1 transcript levels from the time of diagnosis at each time point after transplantation and a >/=4-log reduction at >/=12 months.

  6. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (显示 TFF1 ELISA试剂盒) are mechanistically connected to CEBPB (显示 CEBPB ELISA试剂盒) and that cross-regulation between CEBPB (显示 CEBPB ELISA试剂盒)-RUNX1t1-TFF1 (显示 TFF1 ELISA试剂盒) plays an important role in gastric carcinogenesis.

  7. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  8. Leukaemogenesis by AML1-ETO requires enhanced C/D box snoRNA/RNP formation.

  9. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (显示 RUNX1 ELISA试剂盒)-175) of AML1 (显示 RUNX1 ELISA试剂盒)-ETO is consistent with its contribution to the activity of full-length AML1 (显示 RUNX1 ELISA试剂盒)-ETO and is mediated through its direct association with the DNA-binding domain

  10. the AML1 (显示 RUNX1 ELISA试剂盒)-ETO fusion protein increases the expression of SIRT1 (显示 SIRT1 ELISA试剂盒), possibly by binding to the promoter region of SIRT1 (显示 SIRT1 ELISA试剂盒) to activate its transcription in t(8;21) AML (显示 RUNX1 ELISA试剂盒).

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Results suggest that AML1 (显示 RUNX1 ELISA试剂盒)/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  2. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (显示 TFF1 ELISA试剂盒) are mechanistically connected to CEBPB (显示 CEBPB ELISA试剂盒) and that cross-regulation between CEBPB (显示 CEBPB ELISA试剂盒)-RUNX1t1-TFF1 (显示 TFF1 ELISA试剂盒) plays an important role in gastric carcinogenesis.

  3. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  4. Leukaemogenesis by AML1-ETO requires enhanced C/D box snoRNA/RNP formation.

  5. Data show that RUNX1 (显示 RUNX1 ELISA试剂盒)-ETO;c-Kit(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (显示 BCL11A ELISA试剂盒) (AML (显示 RUNX1 ELISA试剂盒)) in a fraction (51%) of reconstituted mice.

  6. Self-renewal induced by AML1 (显示 RUNX1 ELISA试剂盒)/ETO in primary murine progenitors was inhibited when Aes (显示 AES ELISA试剂盒) was decreased or absent.

  7. AML1 (显示 RUNX1 ELISA试剂盒)-ETO synergizes with an ICSBP (显示 IRF8 ELISA试剂盒) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  8. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (显示 CEBPB ELISA试剂盒) and a novel regulator of early adipogenesis

  9. the loss of the molecular events of AML1 (显示 RUNX1 ELISA试剂盒)-ETO C-terminal NCoR (显示 NCOR1 ELISA试剂盒)/SMRT-interacting domain transforms AML1 (显示 RUNX1 ELISA试剂盒)-ETO into a potent leukemogenic protein

  10. p15(Ink4b (显示 CDKN2B ELISA试剂盒)) loss must be accompanied by additional oncogenic changes for RUNX1 (显示 RUNX1 ELISA试剂盒)-ETO-associated AML (显示 RUNX1 ELISA试剂盒) to develop

RUNX1T1 抗原简介

Antigen Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1) 抗体
  • RUNX1 translocation partner 1 L homeolog (runx1t1.L) 抗体
  • RUNX1 translocation partner 1 (RUNX1T1) 抗体
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1) 抗体
  • RUNX1 translocation partner 1 (Runx1t1) 抗体
  • AML1T1 抗体
  • Cbfa2t1 抗体
  • Cbfa2t1h 抗体
  • CDR 抗体
  • ETO 抗体
  • MTG8 抗体
  • si:ch211-232j17.1 抗体
  • wu:fi14b07 抗体
  • zgc:154044 抗体
  • ZMYND2 抗体

Protein level used designations for RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPECIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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