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RASD1 encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone.
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Studies indicate potential roles for Rasd1 small G protein (显示 RAC2 抗体) and leptin (显示 LEP 抗体) in TRPC4 (显示 TRPC4 抗体) cation channel (显示 TRPV1 抗体) activation.
Data indicate that protein kinase A (PKA) phosphorylates only serine-253 amino acid on activator of G-protein signaling 1 protein Dexras1 (RASD1).
Loss of RASD1 is associated with prostate cancer.
Study showed that Rasd1 and NonO (显示 NONO 抗体) interact at the CRE-site of specific target genes.
Rasd1 modulates endogenous renin (显示 REN 抗体) gene expression by interacting with Ear2 (显示 NR2F6 抗体).
A glucocorticoid response element (GRE) was identified in the 3'-flanking region (2.3 kb downstream of poly(A) signal) of the human Dexras1 gene. A point mutation within the 15-bp GRE abolished this glucocorticoid responsiveness
yeast two hybrid analysis and co-immunoprecipitation studies in mammalian cells demonstrate a direct interaction between AGS1 (显示 TREX1 抗体) and the G(beta1) subunit of heterotrimeric G proteins
does not alter the membrane translocation of protein kinase C delta (显示 PKCd 抗体).
Dexras1 plays a critical role in shaping the photic phase response curve (PRC (显示 PPRC1 抗体)) and the signaling events through which it regulates clock entrainment in transgenic mice.
dex-ras1 mRNA is not induced by glucocorticoid stimulation in HEK293 cells
These results suggest that Dexras1 is a critical mediator of the IGF-1 (显示 IGF1 抗体) signal to activate MAPK (显示 MAPK1 抗体), linking glucocorticoid signaling to IGF-1 (显示 IGF1 抗体) signaling in adipogenesis.
These findings suggest that RASD1 acts as a novel signaling molecule and plays an important role in regulating dynamic uterine remodeling during the estrous cycle in the uterus.
This study demonstrated that provide unprecedented evidence for a selective epigenetic up-regulation of Dexras 1 gene expression in the striatum of EAE mice.
RASD1 is a novel factor in Metaphase I-Metaphase II oocyte transition and may be involved in regulating the progression of cytokinesis and spindle formation
Results suggest a potential role for Dexras1 in modulating a selective subset of psychiatric symptoms, possibly via its interaction with NMDARs and/or other disease-related binding-partners
two mechanisms of Rasd1 induction in the hypothalamus, were identified.
Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase (显示 RACGAP1 抗体), Dexras1
Dexras1 mediates adipogenesis and diet-induced obesity.
Dexras1 is involved in the circadian clock regulation
Dexras1 appears to mediate N-methylaspartate (NMDA)-elicited neurotoxicity via nitric oxide and iron influx.
This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
activator of G-protein signaling 1
, dexamethasone-induced Ras-related protein 1
, ras-related protein
, DEXRAS1 (Dexras1)