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This intronless gene belongs to a family of RAS-related genes. 再加上，我们可以发RAP2B 蛋白 (8)和数多这个蛋白质的别的产品。
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these results revealed that Rap2B promotes renal cell carcinoma (显示 MOK 抗体) angiogenesis via phosphoinositide 3-kinase/AKT (显示 AKT1 抗体)/vascular endothelial growth factor (显示 VEGF 抗体) signaling pathway, which suggests that Rap2B is a novel therapeutic target for renal cell carcinoma (显示 MOK 抗体) anti-angiogenesis therapy.
our results suggested that Rap2b may be a potential therapeutic target for lung cancer.
knockdown of Rap2B inhibits the proliferation and invasion in HCC (显示 FAM126A 抗体) cells. These findings reveal that Rap2B plays an important role in the regulation of HCC (显示 FAM126A 抗体) progression.
miR (显示 MLXIP 抗体)-194 is inversely correlated with RAP2B.
Western blot analysis uncovered that elevated Rap2B leads to increased phosphorylation levels of FAK (显示 PTK2 抗体), suggesting that FAK (显示 PTK2 抗体)-dependent pathway might be responsible for the effect of Rap2B on PCa (显示 FLVCR1 抗体) cells migration and invasion.
Expression and DNA methylation (显示 HELLS 抗体) status of the Rap2B gene in human bronchial epithelial cells treated by cigarette smoke condensate
Our collective findings provide preliminary evidence that miR (显示 MLXIP 抗体)-342-3p acts as a tumor suppressor in small cell lung cancer through repression of RAP2B.
Rap2B itself is not necessary for p53 (显示 TP53 抗体)-dependent cell cycle arrest.
Data indicate that rap (显示 LRPAP1 抗体) GTP-binding protein (显示 HCAR3 抗体) Rap2B expression is significantly increased in suprarenal epithelioma and Rap2B can promote the cell migration and invasion abilities, suggesting a target for the treatment of suprarenal epithelioma.
Rap2b mediates the pro-survival function of p53 (显示 TP53 抗体) upon DNA damage.
Taken together, these findings shed light on Rap2B as a therapeutic target for breast cancer.
the putative Rap2 (显示 RAP2A 抗体) binding site of the RPIPx (显示 RUFY3 抗体) RUN domain interacts with the extended segment in a segment-swapping manner
This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.
RAP2B, member of RAS oncogene family
, ras-related protein Rap-2b
, ras-dva small GTPase
, ras-like small GTPase
, small GTP binding protein