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anti-Pyruvate Dehydrogenase Complex, Component X (PDHX) 抗体

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. 再加上，我们可以发Pyruvate Dehydrogenase Complex, Component X 蛋白 (9) 和 和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PDHX 8050 O00330
PDHX 27402 Q8BKZ9
PDHX 311254  
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antibodies-online.cn销售最多的anti-Pyruvate Dehydrogenase Complex, Component X 抗体

Showing 10 out of 69 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
人 山羊 非结合性 ELISA, WB ABIN185236 (1µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. ABIN185389 staining of paraffin embedded Human Pancreas. A) Microwaved antigen retrieval with citrate buffer pH 6 (3µg/ml), HRP-staining. B) Microwaved antigen retrieval with Tris/EDTA buffer pH9 (1µg/ml) , HRP-staining. 100 μg 6至7个工作日
$429.84
详细
人 兔 非结合性 WB WB Image Sample (30 ug of whole cell lysate) A: A431 , B: H1299 C: Hela 10% SDS PAGE antibody diluted at 1:1000 100 μL 3至4个工作日
$466.18
详细
人 山羊 非结合性 IHC, ELISA, WB 100 μg 11至14个工作日
$610.50
详细
人 兔 非结合性 IHC, WB ABIN6273292 at 1/100 staining Human pancreas cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis of extracts of SKOV-3 cells, using PDHX antibody. 100 μL 11至12个工作日
$390.77
详细
人 小鼠 非结合性 IF, WB Western Blot analysis of PDHX expression in transfected 293T cell line by PDHX MaxPab polyclonal antibody.Lane 1: PDHX transfected lysate(55.11 KDa).Lane 2: Non-transfected lysate. PDHX MaxPab polyclonal antibody. Western Blot analysis of PDHX expression in human stomach. 50 μg 11至12个工作日
$440.00
详细
人 兔 非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Human A431 Cells; Lane2: Human Hela Cells; Lane3: Porcine Heart Tissue. Figure. Western Blot; Sample: Recombinant PDHX, Human. 100 μg 15至18个工作日
$350.00
详细
小鼠 兔 非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Mouse Heart Tissue; Lane2: Mouse Brain Tissue; Lane3: Mouse Kidney Tissue. Figure. Western Blot; Sample: Recombinant PDHX, Mouse. 100 μg 15至18个工作日
$360.00
详细
人 兔 非结合性 IF/ICC, WB Western blot analysis of extracts of various cell lines, using PDHX antibody (ABIN5973826) at 1/1000 dilution. Immunofluorescence analysis of U2OS cells using PDHX antibody (ABIN5973826). Blue: DAPI for nuclear staining. 100 μL 11至16个工作日
$426.40
详细
人 兔 非结合性 IHC, IP, WB Western blot analysis of extracts of various cell lines, using PDHX antibody (ABIN5971318). 100 μL 11至16个工作日
$511.69
详细
人 兔 非结合性 IF, WB Western blot analysis of extracts of various cell lines, using PDHX antibody. Immunofluorescence analysis of U2OS cells using PDHX antibody. 200 μL 12至14个工作日
$438.90
详细

引用最多的anti-Pyruvate Dehydrogenase Complex, Component X 抗体

  1. Human Polyclonal PDHX Primary Antibody for IHC (p), ELISA - ABIN544818 : Ling, McEachern, Seyda, MacKay, Scherer, Bratinova, Beatty, Giovannucci-Uzielli, Robinson: Detection of a homozygous four base pair deletion in the protein X gene in a case of pyruvate dehydrogenase complex deficiency. in Human molecular genetics 1998 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal PDHX Primary Antibody for IHC (p), ELISA - ABIN547434 : Roche, Baker, Yan, Hiromasa, Gong, Peng, Dong, Turkan, Kasten: Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms. in Progress in nucleic acid research and molecular biology 2001 (PubMed)

  3. Human Polyclonal PDHX Primary Antibody for IHC (p), IHC - ABIN250349 : Schild, Ruhs, Beiter, Zügel, Hudemann, Reimer, Krumholz-Wagner, Wagner, Keller, Eder, Krüger, Krüger, Braun, Nieß, Steinacker, Mooren: Basal and exercise induced label-free quantitative protein profiling of m. vastus lateralis in trained and untrained individuals. in Journal of proteomics 2015 (PubMed)

更多抗Pyruvate Dehydrogenase Complex, Component X的相互作用对抗体

Human Pyruvate Dehydrogenase Complex, Component X (PDHX) interaction partners

  1. PDHX is a functional target of miR-27b and that this interaction has consequential effects on cell metabolism which facilitate cell growth and progression in breast cancer.

  2. We propose testing for the R446* mutation in PDHX as a rapid first screening in Roma infants with metabolic acidosis.

  3. MiR-26a regulates glucose metabolism of colorectal cancer cells by direct targeting PDHX.

  4. New mutation in PDHX gene found in two unrelated patients with Pyruvate dehydrogenase deficiency.

  5. genetic association with systemic lupus erythematosus to a haplotype between PDHX and CD44 was established.

  6. determination that PDH and complex III exist at a steady-state ratio of 1:100, 1:128 and 1:202 in HeLa cell extracts, fibroblast mitochondria and heart tissue mitochondria, respectively

  7. model of the pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and binding of the E1 and E3 components

  8. specificity of pairing for human E3BP with E3 from its subcomplex structure to be most likely due to conformational rigidity of the binding fragment of the E3-binding domain of E3BP and its exquisite amino acid match with the E3 target interface

  9. A cluster of disease-causing E3 mutations located near the center of the E3BD/E3 interface prevents the efficient recruitment of these E3 variants by E3BP into the PDC, leading to the dysfunction of the PDC catalytic machine.

  10. These data provide an additional case of E3BP deficiency with a unique and previously unreported deletion in the PDHX gene.

  11. Despite the presence of antibodies reactive with PDC-E3BP in the majority of primary biliary cirrhosis (PBC) patients this self-protein is not a dominant T-cell autoantigen in PBC.

  12. PDHX-assisted photosensitization with rose Bengal induces structural and functional alteration of mitochondria in HeLa cells.

Mouse (Murine) Pyruvate Dehydrogenase Complex, Component X (PDHX) interaction partners

  1. T1a/podoplanin is first expressed in prox 1-positive lymphatic progenitor cells, with predominant localization in the luminal plasma membrane of lymphatic endothelial cells during later development.

  2. In islet cells both fat and glucose regulate PDK gene and protein expression and indicate that hyperglycemia and hyperlipidemia contribute to the decline in diabetic islet PDH activity by increasing mRNA and protein expression of PDK.

Cow (Bovine) Pyruvate Dehydrogenase Complex, Component X (PDHX) interaction partners

  1. This study showed that the recombinant and bovine E2/E3BP cores bind E3s with a 2:1 stoichiometry, and propose that mammalian PDC comprises a heterogeneous population of assemblies incorporating a network of E3 cross-bridges above the core surface.

Pyruvate Dehydrogenase Complex, Component X (PDHX) 抗原简介

蛋白简介

The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit\; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with PDHX

  • pyruvate dehydrogenase complex, component X (pdhx) 抗体
  • pyruvate dehydrogenase complex component X (PDHX) 抗体
  • pyruvate dehydrogenase complex component X L homeolog (pdhx.L) 抗体
  • E3-binding protein (pdhX) 抗体
  • pyruvate dehydrogenase complex component X (pdhx) 抗体
  • pyruvate dehydrogenase complex, component X (Pdhx) 抗体
  • Ac1164 抗体
  • AI481367 抗体
  • DDBDRAFT_0168431 抗体
  • DDBDRAFT_0230192 抗体
  • DDB_0168431 抗体
  • DDB_0230192 抗体
  • DLDBP 抗体
  • E3bp 抗体
  • MGC86218 抗体
  • OPDX 抗体
  • PDHX 抗体
  • Pdx1 抗体
  • proX 抗体
  • zgc:66110 抗体
  • zgc:85977 抗体

Protein level used designations for PDHX

pyruvate dehydrogenase complex, component X , pyruvate dehydrogenase protein X component, mitochondrial-like , dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex , lipoyl-containing pyruvate dehydrogenase complex component X , pyruvate dehydrogenase complex, E3-binding protein subunit , pyruvate dehydrogenase complex, lipoyl-containing component X , pyruvate dehydrogenase protein X component, mitochondrial , dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex (E3-binding protein) (proX) , E3-binding protein , E3BP , proX , pyruvate dehydrogenase protein X component

GENE ID SPECIES
393532 Danio rerio
423154 Gallus gallus
447247 Xenopus laevis
451120 Pan troglodytes
8618072 Dictyostelium discoideum AX4
100059260 Equus caballus
100220979 Taeniopygia guttata
100349815 Oryctolagus cuniculus
100379696 Xenopus (Silurana) tropicalis
100455315 Pongo abelii
100475970 Ailuropoda melanoleuca
100544023 Meleagris gallopavo
100586539 Nomascus leucogenys
8050 Homo sapiens
27402 Mus musculus
311254 Rattus norvegicus
475942 Canis lupus familiaris
517402 Bos taurus
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