PDHX 抗体
(Pyruvate Dehydrogenase Complex, Component X (PDHX))
The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit\; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].
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PDHX 抗体 by Grade
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PDHX 抗体 by 适用
Find PDHX 抗体 for a variety of species such as anti-Human PDHX, anti-Mouse PDHX, anti-Rat PDHX. The species listed below are among those available. Click on a link to go to the corresponding products.
PDHX 抗体 by 应用范围
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PDHX 抗体 by 抗体来源
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PDHX 抗体 by 抗原表位
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PDHX 抗体 by 克隆形成能力
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PDHX 抗体 by 克隆
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Popular PDHX 抗体
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
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Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, IHC, ELISA
Validations
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Cat. No.
ABIN7166903
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
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Validations
- (4)
Cat. No.
ABIN521742
Quantity
50 μg
Datasheet
Datasheet
Reactivity
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Application
WB, IP
Validations
- (3)
Cat. No.
ABIN948658
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN563534
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
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Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, IP
Validations
- (2)
Cat. No.
ABIN6145384
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (p), EIA
Validations
- (3)
Cat. No.
ABIN357414
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IF
Validations
- (1)
Cat. No.
ABIN7262258
Quantity
200 μL
Datasheet
Datasheet
Reactivity
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Application
WB
Validations
- (1)
Cat. No.
ABIN2856340
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IC
Validations
- (2)
Cat. No.
ABIN7306614
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
Cat. No.
ABIN708221
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN708223
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN910568
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our PDHX 抗体
: "Basal and exercise induced label-free quantitative protein profiling of m. vastus lateralis in trained and untrained individuals." in: Journal of proteomics, Vol. 122, pp. 119-32, (2015) (PubMed).: "Quantitative proteomics: the copy number of pyruvate dehydrogenase is more than 10(2)-fold lower than that of complex III in human mitochondria." in: FEBS letters, Vol. 529, Issue 2-3, pp. 173-8, (2002) (PubMed).
: "Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms." in: Progress in nucleic acid research and molecular biology, Vol. 70, pp. 33-75, (2001) (PubMed).
Aliases for PDHX 抗体
pyruvate dehydrogenase complex component X (PDHX) 抗体pyruvate dehydrogenase complex, component X (Pdhx) 抗体
pyruvate dehydrogenase complex, component X (pdhx) 抗体
pyruvate dehydrogenase complex component X L homeolog (pdhx.L) 抗体
E3-binding protein (pdhX) 抗体
pyruvate dehydrogenase complex component X (pdhx) 抗体
Ac1164 抗体
AI481367 抗体
DDBDRAFT_0168431 抗体
DDBDRAFT_0230192 抗体
DDB_0168431 抗体
DDB_0230192 抗体
DLDBP 抗体
E3BP 抗体
E3bp 抗体
MGC86218 抗体
OPDX 抗体
PDHX 抗体
PDX1 抗体
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proX 抗体
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