anti-Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase (POMGNT1) 抗体

The protein encoded by POMGNT1 is a type II transmembrane protein that resides in the golgi. 再加上,我们可以发Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase 试剂盒 (8)Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase 蛋白 (7)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
POMGNT1 68273 Q91X88
POMGNT1 55624 Q8WZA1
POMGNT1 362567 Q5XIN7
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Showing 10 out of 24 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-Pomgnt1 Antibody   Titration: 1.0 ug/ml   Positive Control: Mouse Brain 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 ICC, IF, IHC (p), WB IHC-P Image POMGNT1 antibody detects POMGNT1 protein at cytoplasm in mouse liver by immunohistochemical analysis. Sample: Paraffin-embedded mouse liver. POMGNT1 antibody , diluted at 1:500. IHC-P Image Immunohistochemical analysis of paraffin-embedded Cal27 xenograft , using POMGNT1, antibody at 1:500 dilution. 100 μL Log in to see 3至4个工作日
$466.18
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Cow 非结合性 WB 50 μg Log in to see 11至14个工作日
$551.83
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小鼠 非结合性 ELISA, IHC, IHC (p), WB 100 μg Log in to see 11至14个工作日
$537.17
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非结合性 IHC, WB Western blot analysis of extracts of various cells, using POMGNT1 antibody. Immunohistochemistry of paraffin-embedded human prostate using POMGNT1 antibody at dilution of 1:100 (x40 lens). 100 μL Log in to see 11至13个工作日
$366.77
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非结合性 IHC, IHC (p) Immunohistochemistry-Paraffin: POMGNT1 Antibody [NBP1-82193] Staining of human stomach, upper shows distinct cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: POMGNT1 Antibody  - Staining of human heart muscle shows cytoplasmic positivity in myocytes. 0.1 mL Log in to see 10至13个工作日
$494.38
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非结合性 ICC, IHC, IHC (p), WB   100 μL Log in to see 11至14个工作日
$507.83
详细
小鼠 非结合性 IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to POMGNT1 on formalin-fixed paraffin-embedded human liver. [antibody concentration 3 ug/ml] Western Blot detection against Immunogen (36.52 KDa) . 100 μg Log in to see 11至12个工作日
$440.00
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非结合性 IF/ICC, IHC (fp), WB   100 μL Log in to see 6至8个工作日
$431.20
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非结合性 IF, IHC, WB   100 μL Log in to see 2至3个工作日
$429.00
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更多抗Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase的相互作用对抗体

Mouse (Murine) Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase (POMGNT1) interaction partners

  1. Findings suggest that PomGnT1 promotes GBM progression via activation of beta-catenin and may serve as a prognostic factor for glioma patient survival as well as a novel molecular target for anticancer therapy in malignant glioma.

  2. POMGnT1 gene knockout cause basement membrane disruptions in a mouse model of dystroglycanopathy.

  3. Results describe the effect of altered glycosylation of alpha-dystroglycan caused by inactivation of POMGnT1 in the retina.

  4. classical beta1,2-elongation and beta1,6-GlcNAc branching of O-mannose glycan structures are dependent upon the POMGnT1 enzyme and O-mannosylation is not limited solely to alpha-DG in the brain

  5. POMGnT1 knockout mice were viable but with reduced fertility and variable lifespan

  6. The present study provides the first genetic animal model to further dissect the roles of POMGnT1 in MEB disease.

  7. From these findings, we propose that fukutin forms a complex with POMGnT1 and may modulate its enzymatic activity.

  8. POMGnT1(-/-) muscle showed minimal pathological changes with very low-serum creatine kinase levels, and had normally formed muscle basal lamina, but showed reduced muscle mass, reduced numbers of muscle fibers, and impaired muscle regeneration.

Human Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase (POMGNT1) interaction partners

  1. Next-generation sequencing data analysis revealed that all three muscle-eye-brain disease patients had the same novel copy number variations (CNV) g.6668-8257del, which was homozygous in patient 1 and heterozygous in patients 2 and 3.

  2. These findings demonstrate that PomGnT1 might be a new focus of glioblastoma (GBM)research for treatment of recurrent Temozolomide -resistant GBM

  3. The authors have identified a novel mutation in POMGNT1 that causes nonsyndromic autosomal recessive retinitis pigmentosa, adding to the genetic heterogeneity of this retinal disease.

  4. Study identified recessive POMGNT1 mutations in three unrelated non-syndromic retinitis pigmentosa families showing significant impaired POMGNT1 enzymatic activity.

  5. When association tests were applied to data from the Diabetes Heart Study, it found exome variants of POMGNT1 and JAK1 genes were associated with type 2 diabetes.

  6. POMGNT1 Is Glycosylated by Mucin-Type O-Glycans

  7. study presents clinical, neuroradiological, and POMGNT1 findings in 12 muscle-eye-brain disease patients of Turkish origin from 10 families; suggests a genotype-phenotype correlation

  8. Data indicate that Golgi phosphoprotein 3 (GOLPH3) binds to and controls the Golgi localization of protein O-linked mannose beta-1,2-N-acetlyglucosaminyltransferase 1 (POMGnT1).

  9. Identification of novel POMGnT1 mutations in Chinese patients with muscle-eye-brain disease.

  10. POMGnT1 point mutations and protein expression are associated with variably severe muscle-eye-brain disease showing that severity of the phenotype does not correlate with protein expression.

  11. Promoter alteration causes transcriptional repression of the POMGNT1 gene in limb-girdle muscular dystrophy type 2O.

  12. This study demonistreated that Intragenic rearrangements in POMGNT1 gene in muscle-eye-brain disease.

  13. these results show that the amino acid sequence affects POMGnT1 activity.

  14. This study gives a comprehensive biochemical evaluation of all clinically relevant POMGnT1 point mutations known to date, which have been linked to muscle-eye-brain disease or similar conditions.

  15. the function of the gene products is only known for POMT1, POMT2, and POMGnT1, all responsible for the O-mannosylglycan biosynthesis

  16. Merosin-deficient congenital muscular dystrophy with mental retardation and cerebellar cysts, unlinked to the MEB locus, in three Tunisian patients

  17. Loss-of-function of an N-acetylglucosaminyltransferase, POMGnT1, in muscle-eye-brain disease. 13 mutations have been identified in patients with MEB. The mutant POMGnT1s were expressed and none had any activity.

  18. Results describe the identification of a novel O-linked mannose beta1,2-N-acetylglucosaminyltransferase (POMGnT1) gene missense mutation in muscle-eye-brain disease.

  19. DNA mutational analysis and phenotypes in patients with muscle-eye-brain disease

  20. Our results suggest that PomGnT1, enzymes involved in the O-mannosyl glycosylation pathway, play an active role in modulating integrin and laminin-dependent adhesion and migration of human neuronal cells.

Protein O-Linked Mannose Beta1,2-N-Acetylglucosaminyltransferase (POMGNT1) 抗原简介

蛋白简介

The protein encoded by this gene is a type II transmembrane protein that resides in the golgi. It participates in O-mannosyl glycosylation, and is specific for alpha linked terminal mannose. Mutations in this gene are associated with muscle-eye-brain (MEB) disease. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with POMGNT1

  • protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (POMGNT1) 抗体
  • protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) S homeolog (pomgnt1.S) 抗体
  • protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (pomgnt1) 抗体
  • protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase (Pomgnt1) 抗体
  • protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) (Pomgnt1) 抗体
  • 0610016I07Rik 抗体
  • 4930467B06Rik 抗体
  • gnT-I.2 抗体
  • GNTI.2 抗体
  • GnT I.2 抗体
  • im:7151461 抗体
  • LGMD2O 抗体
  • MDDGA3 抗体
  • MDDGB3 抗体
  • MDDGC3 抗体
  • MEB 抗体
  • MGAT1.2 抗体
  • POMGNT1 抗体
  • zgc:158130 抗体

Protein level used designations for POMGNT1

protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase , O-linked mannose beta1,2-N-acetylglucosaminyltransferase , protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 , O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 , O-mannosyl N-acetylglucosaminyltransferase , UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2

GENE ID SPECIES
429097 Gallus gallus
456564 Pan troglodytes
482511 Canis lupus familiaris
495292 Xenopus laevis
571876 Danio rerio
707205 Macaca mulatta
100158594 Xenopus (Silurana) tropicalis
100174367 Pongo abelii
100590586 Nomascus leucogenys
68273 Mus musculus
506551 Bos taurus
55624 Homo sapiens
362567 Rattus norvegicus
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