anti-Poly(rC) Binding Protein 2 (PCBP2) 抗体

The protein encoded by PCBP2 appears to be multifunctional. 再加上,我们可以发PCBP2 蛋白 (9)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PCBP2 5094 Q15366
PCBP2 18521 Q61990
PCBP2 363005  
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antibodies-online.cn销售最多的anti-PCBP2 抗体

Showing 10 out of 61 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 IHC, WB <b>WB Suggested Anti-PCBP2 Antibody Titration: </b>1.25ug/ml<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2至3个工作日
Cow 非结合性 WB <b>WB Suggested Anti-PCBP2 Antibody Titration: </b>2.5ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2至3个工作日
小鼠 非结合性 WB PCBP2 monoclonal antibody (M02), clone 1B6. Western Blot analysis of PCBP2 expression in K-562. 0.1 mg Log in to see 8至11个工作日
非结合性 IC, IF, IHC, WB Immunofluorescent analysis of hnRNP E2 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibo 200 μL Log in to see 13至14个工作日
Cow 非结合性 IHC (p), WB 100 μg Log in to see 7至9个工作日
Bat 非结合性 WB 100 μg Log in to see 7至9个工作日
非结合性 ICC, IF, IHC, IHC (p), WB Immunocytochemistry: PCBP2 Antibody [NBP1-83241] - Immunofluorescence: [NBP1-83241] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli & cytoplasm. Immunohistochemistry-Paraffin: PCBP2 Antibody [NBP1-83241] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes. 0.1 mL Log in to see 10至13个工作日
非结合性 ICC, IF, WB ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using PCBP2, antibody at 1:200 dilution. WB Image Sample (30 ug of whole cell lysate) A: Hep G2 , 10% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 1至2个工作日
小鼠 非结合性 IF, IHC (p), RNAi, ELISA, WB Immunoperoxidase of monoclonal antibody to PCBP2 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml] Immunofluorescence of monoclonal antibody to PCBP2 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 11至12个工作日
小鼠 非结合性 EIA, IF, IHC (p), WB 50 μg Log in to see 6至8个工作日

通过反应活性、应用领域、克隆类型和共轭标记 PCBP2 抗体

特性 应用范围 宿主 克隆类型 标记
Human ,
, , , , ,
Mouse (Murine)

Rat (Rattus)

引用最多的anti-PCBP2 抗体

  1. Human Monoclonal PCBP2 Primary Antibody for IF, IHC (p) - ABIN562121 : Fujimura, Kano, Murata: Identification of PCBP2, a facilitator of IRES-mediated translation, as a novel constituent of stress granules and processing bodies. in RNA (New York, N.Y.) 2008 (PubMed)
    Show all 9 Pubmed References

  2. Cow (Bovine) Polyclonal PCBP2 Primary Antibody for IHC, WB - ABIN2778923 : Oh, Yang, Hahn, Kim, Byun, Jeon, Kim, Song, Noh, Kim, Yoo, Kim, Kim: Transcriptome analysis of human gastric cancer. in Mammalian genome : official journal of the International Mammalian Genome Society 2005 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal PCBP2 Primary Antibody for ICC, IF - ABIN4344023 : Flynn, Martin, Spitale, Do, Sagan, Zarnegar, Qu, Khavari, Quake, Sarnow, Chang: Dissecting noncoding and pathogen RNA-protein interactomes. in RNA (New York, N.Y.) 2014 (PubMed)

  4. Human Monoclonal PCBP2 Primary Antibody for WB - ABIN394008 : Kim, Chang, Yun, Yang, Hong, Kim, Um, Lee, Lee, Hwang: Chloride intracellular channel 1 identified using proteomic analysis plays an important role in the radiosensitivity of HEp-2 cells via reactive oxygen species production. in Proteomics 2010 (PubMed)


Human Poly(rC) Binding Protein 2 (PCBP2) interaction partners

  1. Double immunofluorescence for hnRNP E2 and TDP-43 (显示 TARDBP 抗体) showed most TDP-43 (显示 TARDBP 抗体) immunopositive dystrophic neuritis within frontal and temporal cortex, and the neuronal cytoplasmic inclusions seen in dentate gyrus granule cells, to contain hnRNP E2. Present findings indicate an association between TDP-43 (显示 TARDBP 抗体) and hnRNP E2 which might underlie the pathogenetic mechanism of Semantic Dementia Frontotemporal Lobar Degeneration.

  2. Data suggest that the interaction between PCBP2 and the 3'UTR (显示 UTS2R 抗体) of the ARHGDIA (显示 ARHGDIA 抗体) mRNA may induce a local change in RNA structure that favors subsequent binding of miR (显示 MLXIP 抗体)-151-5p and miR-16 (显示 GDE1 抗体), thus leading to the suppression of ARHGDIA (显示 ARHGDIA 抗体) expression.

  3. To promote intracellular iron flux, an iron chaperone appears to be essential for receiving iron from heme catabolism. Data suggest that PCBP2 competes with CPR (显示 POR 抗体) for binding HO1 (显示 HMOX1 抗体); PCBP2 K homology 3 domain is important for HO1 (显示 HMOX1 抗体)/PCBP2 interaction; heme prompts HO1 (显示 HMOX1 抗体)/CPR (显示 POR 抗体) multimer and decreases HO1 (显示 HMOX1 抗体)/PCBP2 multimer. [PCBP2 = poly(rC) binding protein 2; CPR (显示 POR 抗体) = cytochrome P450 reductase (显示 POR 抗体); HO1 (显示 HMOX1 抗体) = heme oxidase 1]

  4. BC200 RNA interacts with hnRNP E1 (显示 PCBP1 抗体) and E2 mainly through its unique 3' C-rich domain.

  5. Study determined that PCBP2 specifically associates with components of this kinase cascade and regulates the activities of its downstream transcriptional coactivators.

  6. These results suggest that FPN1 (显示 SLC40A1 抗体) exports iron received from the iron chaperone PCBP2. Therefore, it was found that PCBP2 modulates cellular iron export, which is an important physiological process.

  7. PCBP2 was overexpressed in esophageal squamous cell carcinoma tissues and cell lines. PCBP2 expression promoted proliferation of ESCC cells. We also found that reduced PCBP2 expression might induce ESCC cell apoptosis with increased cleaved caspase3 expression. Overall, our findings indicated that PCBP2 might be involved in the ESCC progression and be considered as a new treatment target in ESCC.

  8. High expression of PCBP2 may contribute to sorafenib resistance in hepatocellular carcinoma cells.

  9. our data indicate that miR (显示 MLXIP 抗体)-214 may function as tumor suppressor in glioma by targeting PCBP2

  10. beta2-adrenergic receptor (显示 ADRB2 抗体) signaling promotes pancreatic ductal adenocarcinoma progression by facilitating PCBP2-dependent c-myc (显示 MYC 抗体) expression.

Mouse (Murine) Poly(rC) Binding Protein 2 (PCBP2) interaction partners

  1. Study determined that PCBP2 specifically associates with components of this kinase cascade and regulates the activities of its downstream transcriptional coactivators.

  2. data suggest that PCBP2 regulates p73 (显示 ARHGAP24 抗体) expression via mRNA stability and p73 (显示 ARHGAP24 抗体)-dependent biological function in ROS (显示 ROS1 抗体) production and cellular senescence.

  3. PCBP2 overexpression rescues the Meis1 (显示 MEIS1 抗体) effects of Akt (显示 AKT1 抗体)-mTOR (显示 FRAP1 抗体) pathway and hypertrophy of cardiomyocytes.

  4. These data reveal that Pcbp1 (显示 PCBP1 抗体) and Pcbp2 are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.

  5. PCBP2 knockdown promoted angiotensin II-induced hypertrophy (increase in cell size, protein synthesis and activation of fetal genes) of cardiomyocytes, while PCBP2 overexpression obtained oppose effects.

  6. Our analysis of PCBP1 (显示 PCBP1 抗体) and PCBP2 expression demonstrates robust expression of these two proteins within the gastric epithelium with high concordance for both proteins in their cell-type specificities and intracellular distributions.

  7. This study demonstrates for the first time that alpha-CP2 functions as a transcriptional activator by binding to a single-stranded poly(C) sequence.

  8. This study provides evidence that PCBP2 and hnRNP A1 (显示 HNRNPA1 抗体) bind to the 5' and 3' ends of the murine norovirus 1 viral RNA and contribute to RNA circularization, playing a role in the virus life cycle.

  9. PCBP2-AIP4 (显示 ITCH 抗体) axis defines a new signaling cascade for MAVS (显示 MAVS 抗体) degradation and 'fine tuning' of antiviral innate immunity.

Pig (Porcine) Poly(rC) Binding Protein 2 (PCBP2) interaction partners

  1. These results indicated that Nsp1beta of porcine reproductive and respiratory syndrome virus is able to bind and interact with cellular PCBP2 strongly in both the infected cells and plasmid transfected cells.

  2. Overall, the results presented here point toward an important role for PCBP1 (显示 PCBP1 抗体) and PCBP2 in regulating porcine reproductive and respiratory syndrome virus RNA synthesis via binding to viral nonstructural protein 1beta.

PCBP2 抗原简介


The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with PCBP2

  • poly(rC) binding protein 2 (PCBP2) 抗体
  • poly(rC) binding protein 2 (Pcbp2) 抗体
  • poly(rC) binding protein 2 (pcbp2) 抗体
  • poly(rC) binding protein 2 L homeolog (pcbp2.L) 抗体
  • alphaCP-2 抗体
  • AW412548 抗体
  • fb36h02 抗体
  • hnRNP-E2 抗体
  • HNRNPE2 抗体
  • HNRPE2 抗体
  • Hnrpx 抗体
  • PCBP2 抗体
  • PCBP3 抗体
  • wu:fb36h02 抗体
  • zgc:55964 抗体

Protein level used designations for PCBP2

alpha-CP2 , heterogeneous nuclear ribonucleoprotein E2 , heterogenous nuclear ribonucleoprotein E2 , hnRNP E2 , poly(rC)-binding protein 2 , CBP , CTBP , heterogeneous nuclear ribonucleoprotein X , hnRNP X , putative heterogeneous nuclear ribonucleoprotein X , poly(rC) binding protein 2 , poly(rC) binding protein 3 , PolyrC-binding protein 2 , poly(rc)-binding protein 2 , heterogeneous nuclear ribonucleoprotein

5094 Homo sapiens
18521 Mus musculus
321844 Danio rerio
363005 Rattus norvegicus
399399 Xenopus laevis
420965 Gallus gallus
477596 Canis lupus familiaris
540653 Bos taurus
733863 Xenopus (Silurana) tropicalis
100194880 Salmo salar
100528911 Ictalurus punctatus
397665 Sus scrofa
100731593 Cavia porcellus
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