Periostin, Osteoblast Specific Factor (POSTN) ELISA试剂盒

Human Periostin, Osteoblast Specific Factor (POSTN) interaction partners

1. POSTN is associated with pathological processes such as metastasis and invasion of liver cancer

2. The combination of POSTN and PTK7 might be a potential prognostic and diagnostic indicator and a promising therapeutic target.

3. Periostin expression was significantly increased in patients with CAC. Periostin aggravates CAC development.

4. serum POSTN can be a novel biomarker for postoperative recurrence of chronic rhinosinusitis with nasal polyps.

5. The periostin (PN)-mediated collagen structure enhanced the mechanical strength of the surrounding fibrous tissues and activated chondrocyte extracellular signaling by interstitial fibrous tissues.

6. hese findings highlight the importance of periostin and YKL40 as serum biomarkers for assessment of asthma severity and acute asthma exacerbations in children with asthma.

7. Serum Periostin (POSTN) levels were significantly higher in patients with CRC compared with healthy controls and associated with clinical stages.

8. these data showed that mouse periostin was degraded at the bone metastatic sites, potentially by cathepsin K, and that the specific measurement of C-terminal intact periostin PTN in serum should assist in detecting bone metastasis formation in breast cancer in humans

9. Our present findings demonstrate the significance of the IL-13/periostin/IL-24 pathway in the pathogenesis of skin allergic inflammation and help to explain and support the utility of the inhibitors of this pathway such as dupilumab and tofacitinib.

10. Thus, periostin level seems to be a strongly related factor for asthma and allergic rhinitis after 5 years of age, since the predicted medians in both subclinical and clinical allergy children were higher than those in non-allergic children.

11. In our sample of children with uncontrolled asthma, serum periostin levels did not discriminate between severe and nonserious asthma.

12. Activated hepatic stellate cells promote the tumor progression of heat-treated residual hepatocellular carcinoma through the release of POSTN.

13. POSTN total immunoreactive score on prostate cancer biopsy samples independently predicted the risk of recurrence, progression, and death in patients with localized disease and in those with low to intermediate Gleason scores.

14. revascularization and progression of pancreatic neuroendocrine tumors (PNETs) under extended vascular-endothelial growth factor A (VEGFA) blockade are dependent on periostin (POSTN), a matricellular protein expressed by stromal cells.

15. Our results show that s-periostin is elevated in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). S-periostin, s-IgE, and s-SE-IgE may be used as biomarkers to predict the expression of IL-5 or SE-IgE in nasal polyp tissue, that is, identifying patients with CRSwNP with moderate and severe type 2 inflammation.

16. otch signaling directly regulates transcription of POSTN in hepatocytes and liver cancer cell lines and may be a candidate for drug targeting in liver cancer.

17. the present study revealed that periostin might promote angiogenesis and eosinophil recruitment, indicating that periostin is a critical matricellular component in remodelling the tissue microenvironment in ENP.

18. Periostin upregulates the effector functions of eosinophils.

19. this study found no longitudinal variation of serum periostin levels in adults with stable asthma

20. the crystal structures of human periostin (EMI-Fas1(I-)(IV) ) and its Cys60Ala mutant. In combination with multi-angle light-scattering analysis and biochemical assays, the crystal structures reveal that periostin mainly exists as a dimer in solution and its homophilic interaction is mainly mediated by the EMI domain.

Mouse (Murine) Periostin, Osteoblast Specific Factor (POSTN) interaction partners

1. The periostin-p21-activated kinase 1-induced Akt1 protects cells from apoptosis through suppression of transcriptional activation of Forkhead-Transcription-Factor (FKHR).

2. Periostin expression was significantly increased in patients with colitis-associated colon cancer (CAC). Periostin aggravates CAC development.

3. data indicated that the regulation of Postn in visceral fat could be beneficial for the maintenance of healthy adipose tissue in obesity.

4. Periostin stimulates signaling pathways involved in an abnormal tissue repair process that contributes to cyst growth and fibrosis polycystic kidney disease.

5. these data showed that mouse periostin was degraded at the bone metastatic sites, potentially by cathepsin K, and that the specific measurement of C-terminal intact periostin PTN in serum should assist in detecting bone metastasis formation in breast cancer in humans

6. findings show that Schwann cells promote macrophage infiltration by upregulating Postn and suggest that POSTN is a novel target for the treatment of macrophage-associated inflammatory neuropathies.

7. loss of periostin attenuates lipid metabolism in adipose tissue, thus recapitulating one aspect of age-related metabolic dysfunction.

8. marker of renal fibrosis and may augment the progression of fibrogenesis as an extracellular matrix protein

9. revascularization and progression of pancreatic neuroendocrine tumors (PNETs) under extended vascular-endothelial growth factor A (VEGFA) blockade are dependent on periostin (POSTN), a matricellular protein expressed by stromal cells.

10. Increased expression of Periostin promotes liver fibrogenesis by activating lysyl oxidase.

11. Inhibition of periostin could be important for suppressing capsule formation on silicone implants after in vivo implantation.

12. Unaffected by Postn, Vav-Itgav(-/-) haematopoietic stem cell proliferate faster in vitro, illustrating the importance of Postn-Itgav interaction.

13. Periostin-expressing myofibroblasts in the heart derive from tissue-resident fibroblasts of the Tcf21 lineage and are necessary for adaptive healing and fibrosis.

14. mesenchymal source, specific to cardiovascular tissues, roles in cardiovascular development and disease [review]

15. Results indicate that periostin is a key player in the development of bleomycin-induced fibrosis and consequent enhancement of tumor cell colonization in the lung.

16. Periostin gene deletion impairs periosteal cells functions and fracture consolidation.

17. these data indicate that CatK not only plays a major role in bone remodeling but also modulates modeling-based cortical bone formation by degrading periostin and thereby moderating Wnt-beta-catenin signaling.

18. Ablation of periostin suppresses post-infarction myocardial regeneration by inhibiting the PI3K/GSK3beta/cyclin D1 signalling pathway, indicating that periostin is essential for myocardial regeneration.

19. this study shows that periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis

20. Genetic or pharmaco-genetic inhibition of periostin in animal models of renal disease was efficient in arresting the progression of the kidney pathology. (Review)

Cow (Bovine) Periostin, Osteoblast Specific Factor (POSTN) interaction partners

1. These results suggest that periostin is one of the local contributing factors in bone and periodontal tissue remodeling following mechanical stress during experimental tooth movement [periostin].