PHD Finger Protein 6 (PHF6) ELISA试剂盒

PHF6 is a member of the plant homeodomain (PHD)-like finger (PHF) family. 再加上,我们可以发PHF6 抗体 (54)PHF6 蛋白 (7)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
PHF6 84295 Q8IWS0
小鼠 PHF6 PHF6 70998 Q9D4J7
大鼠 PHF6 PHF6 100359714  
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产品编号 适用 灵敏度 范围 图像 规格 供应商 交付 价格 详细
9.375 pg/mL 15.63 pg/mL - 1000 pg/mL A typical standard curve 96 Tests Log in to see 13至16个工作日

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Human PHD Finger Protein 6 (PHF6) interaction partners

  1. EZH2 (显示 EZH2 ELISA试剂盒) mutations coexisted with mutations of NOTCH1 (显示 NOTCH1 ELISA试剂盒), IL7R (显示 IL7R ELISA试剂盒), and PHF6 in the two Adult T-cell Acute Lymphoblastic Leukemia patients, and they responded poorly to chemotherapy and experienced difficult clinical histories and inferior outcomes

  2. PHF6 mutations occur at a low frequency in pediatric acute myeloid leukemia (显示 BCL11A ELISA试剂盒) in both female and male patients

  3. PHF6 defects most likely result in their loss of function and have a substantial effect on the evolution into the aggressive types of myeloid neoplasms, associated with other concomitant genetic defects including RUNX1 (显示 RUNX1 ELISA试剂盒) mutations

  4. The mutations of the gene encoding plant homeodomain (PHD)-like finger protein 6 (PHF6) contribute to the pathogenesis of the X-linked intellectual disability disorder Borjeson-Forssman-Lehmann syndrome.

  5. PHF6 localizes to the sub-nucleolar fibrillar center where it binds to rDNA-coding sequences. PHF6 mediates the overall levels of ribosome biogenesis within a cell.

  6. Our results suggest that PHF6 may function as an oncogenic factor in several types of cancer. We also hypothesize that PHF6 may also play its role in a tissue-specific manner. Our findings suggest further investigations regarding the exact role of PHF6 in tumor types.

  7. Female phenotypes of Borjeson-Forssman-Lehmann syndrome patients with PHF6 mutations

  8. Our RBBP4 (显示 RBBP4 ELISA试剂盒)-PHF6 complex structure provides insights into the molecular basis of PHF6-NuRD complex interaction and implicates a role for PHF6 in chromatin structure modulation and gene regulation.

  9. Phf6 is a "lineage-specific" cancer gene that plays opposing roles in developmentally distinct hematopoietic malignancies.

  10. The PHF6 tumor suppressor gene was targeted in acute lymphoblastic leukemia by microRNA-128-3p.

Mouse (Murine) PHD Finger Protein 6 (PHF6) interaction partners

  1. active maintenance of a precise chromatin landscape is essential for sustaining proper leukemia cell identity and that loss of a single factor (PHF6) can cause focal changes in chromatin accessibility and nucleosome positioning that render cells susceptible to lineage transition

  2. These results place miR (显示 MLXIP ELISA试剂盒)-128 upstream of PHF6 in a pathway vital for cortical lamination as well as for the development of neuronal morphology and intrinsic excitability.

  3. As part of a cell-intrinsic transcriptional pathway, PHF6 regulates neuronal migration in the brain.

  4. Strongest Phf6 gene expression and nuclear localisation of Phf6 protein were observed in the developing central nervous system, the anterior pituitary gland, the primordia of facial structures and the limb buds.

PHF6 抗原简介

Antigen Summary

This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms.

Gene names and symbols associated with PHF6

  • PHD finger protein 6 (phf6) 抗体
  • PHD finger protein 6 L homeolog (phf6.L) 抗体
  • PHD finger protein 6 (PHF6) 抗体
  • PHD finger protein 6 (Phf6) 抗体
  • 2700007B13Rik 抗体
  • 4931428F02Rik 抗体
  • BFLS 抗体
  • BORJ 抗体
  • CENP-31 抗体
  • mKIAA1823 抗体
  • wu:fa22g03 抗体
  • zgc:55403 抗体

Protein level used designations for PHF6

PHD finger protein 6 , PHD-like zinc finger protein , centromere protein 31

327070 Danio rerio
495066 Xenopus laevis
707390 Macaca mulatta
779543 Xenopus (Silurana) tropicalis
100151997 Sus scrofa
100225613 Taeniopygia guttata
100346149 Oryctolagus cuniculus
100379647 Monodelphis domestica
735789 Pan troglodytes
100054177 Equus caballus
84295 Homo sapiens
422235 Gallus gallus
612921 Canis lupus familiaris
518186 Bos taurus
70998 Mus musculus
100359714 Rattus norvegicus
100174671 Pongo abelii
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