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MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. 再加上，我们可以发Nuclear Transcription Factor, X-Box Binding 1 蛋白 (3)和数多这个蛋白质的别的产品。
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This study identifies NFX1-123 as a critical host protein partner through which 16E6 is able to subvert the immune response and in turn permit a long-lived high-risk Human papillomavirus infection.
The results showed that a repressor complex composed of NFX1-91, mSin3A and histone deacetylase 1 was involved in the PKC-delta-induced repression of the hTERT promoter, which resulted in the repression of hTERT transcription.
Human papillomavirus 16 E6 (16E6) interacts with the cellular protein NFX1-123, and they collaboratively increase the growth and differentiation master regulator, Notch1.
NFX1-123 and human papillomavirus 16E6 upregulated Notch 1 expression in keratinocytes.
a mechanism for HPV16 E6 activation of the NFkappaB pathway through NFX1-91
HuD acts as a novel adaptor protein to recruit TAP for efficient export of ARE-containing mRNAs in neuronal cells
the induction of hTERT telomerase by the HPV-16 E6/E6-AP complex involves targeting of NFX1-91, a newly identified repressor of telomerase, for ubiquitination and degradation.
Nrf1 is normally targeted to the endoplasmic reticulum membrane and endoplasmic reticulum stress may play a role in modulating Nrf1 function as a transcriptional activator
data suggest that NFX1-123 is integral to hTERT regulation in HPV16 E6-expressing epithelial cells and that the interaction between NFX1-123 and poly(A) binding proteins is critical to hTERT activity
These data demonstrate that targeted degradation of NFX1-91 by E6/E6AP dissociates the mSin3A/HDAC complex from the hTERT promoter and induces hTERT transcription.
NFX1-123 is a cytoplasmic protein that colocalizes with poly(A) binding proteins, and binds hTERT mRNA in HPV16 E6-expressing keratinocytes.
Mutation E610G, quantitatively accounts for the Nxf1 modifier gene activity toward IAP insertion.
nuclear accumulation and modulation of unfolded protein response regulated by subunit of phosphoinositide 3-kinase
nuclear translocation regulated by p85alpha and p85beta monomers of PI3K
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
nuclear transcription factor, X-box binding 1
, nuclear transcription factor, x-box binding 1
, transcriptional repressor NF-X1-like
, nuclear transcription factor, X box-binding protein 1
, transcriptional repressor NF-X1
, nuclear X box binding factor 1
, testis expressed gene 42