Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) ELISA试剂盒

displays differential expression after induction by nerve growth factor [RGD, Feb 2006].. 再加上,我们可以发NEDD8 抗体 (129)NEDD8 蛋白 (29)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
NEDD8 4738 Q15843
NEDD8 18002 P29595
NEDD8 25490 Q71UE8
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适于 NEDD8 相互作用对的更多 ELISA 试剂盒

Human Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) interaction partners

  1. Nedd8 binding to Smurf plays important roles in the regulation of cell migration and the BMP and TGFbeta (显示 TGFB1 ELISA试剂盒) signaling pathways.

  2. NEDD8-mediated neddylation promotes stress granule assembly.

  3. NEDD8 seems to inhibit the Src (显示 SRC ELISA试剂盒)-mediated phosphorylation of caveolin-1 (显示 CAV1 ELISA试剂盒) by modifying the structure of caveolin-1 (显示 CAV1 ELISA试剂盒) protein, which blocks the migration of cancer cells. Although the neddylation process is currently regarded as an emerging target for cancer therapy, our results suggest the possibility that the inhibition of neddylation could facilitate cancer invasion or metastasis at least in some types of cancers.

  4. The cellular effects of NEDD8 inhibition can be manipulated based on the p53 (显示 TP53 ELISA试剂盒) status.

  5. Here we report that high expression of neddylation components, NEDD8 and NAE1, are associated with poor survival of Pancreatic ductal adenocarcinoma patients. Blockage of neddylation by MLN4924 significantly sensitizes pancreatic cancer cells to gemcitabine, reduced clonogenic survival, decreased invasion capacity, increased apoptosis and senescence

  6. Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.

  7. Furthermore, the authors characterized SENP8/DEN1 (显示 SENP8 ELISA试剂盒) as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8 (显示 SENP8 ELISA试剂盒)-deficient cells.

  8. MKK7 (显示 MAP2K7 ELISA试剂盒) undergoes neddylation in human breast cancer cells

  9. complete blocking of CRLs at a higher inhibitor dose-induced cytotoxicity that was amplified by knockdown of CRL (显示 IL31RA ELISA试剂盒) regulator Cand1 (显示 CAND1 ELISA试剂盒).

  10. In conclusion, the authors revealed that E3 ligase HDM2 promotes NEDD8 NEDDylation of HBx to enhance HBx stability and chromatin localization, which in turn favors HBx-dependent transcriptional regulation, cell proliferation, and hepatitis B virus-driven tumor growth.

Mouse (Murine) Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) interaction partners

  1. Downregulation of NEDD8 enhanced the susceptibility of nasopharyngeal carcinoma cells to cisplatin and radiation.

  2. Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.

  3. neural precursor cell expressed developmentally downregulated protein 8 (Nedd8) modification of Cul-5 (显示 CUL5 ELISA试剂盒) is required for its interaction with TRAF6 (显示 TRAF6 ELISA试剂盒).

  4. Our findings provide mechanistic evidence of the effects of IAP (显示 ALPI ELISA试剂盒) antagonists in combination with NAE inhibitors, and demonstrate the potential of a new combination therapy for cancer.

  5. a role of Nedd8 in regulating caspase-1 (显示 CASP1 ELISA试剂盒) activation following inflammasome activation

  6. Nedd8 and its associated E2 carrier protein (Ubc12) and E3-SCF (显示 KITLG ELISA试剂盒) ligase play a key role in regulating the expression and activity of ENaC (显示 SCNN1A ELISA试剂盒) in alveolar pneumocytes.

  7. a new regulatory mechanism of RCAN1 (显示 RCAN1 ELISA试剂盒) function

  8. c-Cbl conjugates neural precursor cell-expressed, developmentally downregulated 8 (NEDD8), a ubiquitin-like protein, to TbetaRII at Lys556 and Lys567.

  9. The NEDD8 pathway appears to play an important role in CD4 (显示 CD4 ELISA试剂盒)+ T-cell-mediated inflammatory responses

  10. Nedd8 and AhR (显示 AHR ELISA试剂盒) localize to overlapping areas in the heart and spinal ganglia, raising the possibility that this interaction may play a role in organogenesis

Fruit Fly (Drosophila melanogaster) Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8) interaction partners

  1. the Cul1 (显示 CUL1 ELISA试剂盒)-based SCF (显示 KITLG ELISA试剂盒) complex requires Nedd8 modification for the degradation processes of Ci, Arm, and CycE (显示 CCNE1 ELISA试剂盒) in vivo

  2. Genetic analyses indicate that a balance between neddylation and deneddylation maintained by DEN1 (显示 SENP8 ELISA试剂盒) is crucial for animal viability.

NEDD8 抗原简介

Antigen Summary

displays differential expression after induction by nerve growth factor

Gene names and symbols associated with NEDD8

  • neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) 抗体
  • neural precursor cell expressed, developmentally down-regulated gene 8 (Nedd8) 抗体
  • neural precursor cell expressed, developmentally down-regulated 8 (Nedd8) 抗体
  • CG10679 gene product from transcript CG10679-RB (Nedd8) 抗体
  • neural precursor cell expressed, developmentally down-regulated 8 (nedd8) 抗体
  • Nedd8 (Nedd8) 抗体
  • ubiquitin-like protein Nedd8 (nedd8) 抗体
  • neural precursor cell expressed, developmentally down-regulated 8 L homeolog (nedd8.L) 抗体
  • CG10679 抗体
  • DDBDRAFT_0218116 抗体
  • DDBDRAFT_0238041 抗体
  • DDB_0218116 抗体
  • DDB_0238041 抗体
  • Dmel\\CG10679 抗体
  • dNEDD8 抗体
  • GB17785 抗体
  • NEDD-8 抗体
  • nedd8 抗体
  • nedd8.S 抗体
  • Rub1 抗体
  • si:zc14a17.5 抗体
  • ubiquitin 抗体

Protein level used designations for NEDD8

neddylin , ubiquitin-like protein Nedd8 , NEDD-8 , NEDD8 , neural precursor cell expressed developmentally down-regulated protein 8 , neural precursor cell expressed, developmentally down-regulated gene 8 , CG10679-PA , Nedd8-PA , neural precursor cell-expressed developmentally downregulated , neural precursor cell expressed, developmentally down-regulated 8 , Nedd8 , NEDD8 protein , neural precursor cell expressed, developmentally down-regulated 8 S homeolog

GENE ID SPECIES
4738 Homo sapiens
18002 Mus musculus
25490 Rattus norvegicus
35151 Drosophila melanogaster
286796 Bos taurus
368667 Danio rerio
480265 Canis lupus familiaris
549727 Xenopus (Silurana) tropicalis
552822 Apis mellifera
715763 Macaca mulatta
8621655 Dictyostelium discoideum AX4
100009008 Oryctolagus cuniculus
100301786 Oncorhynchus mykiss
100528101 Ictalurus punctatus
100520086 Sus scrofa
446966 Xenopus laevis
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