anti-Myocilin (MYOC) 抗体

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. 再加上,我们可以发Myocilin 蛋白 (23)Myocilin 试剂盒 (7)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MYOC 17926 O70624
MYOC 4653 Q99972
MYOC 81523 Q9R1J4
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Showing 10 out of 59 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
豚鼠 非结合性 WB 100 μL Log in to see 2至3个工作日
非结合性 EIA, IHC (p) 50 μg Log in to see 6至8个工作日
小鼠 非结合性 IHC, WB 100 μL Log in to see 13至14个工作日
小鼠 非结合性 EIA, IHC (p), WB 50 μg Log in to see 6至8个工作日
非结合性 IHC (p), ELISA Human Eye, Retina (formalin-fixed, paraffin-embedded) stained with MYOC antibody ABIN334270 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7至9个工作日
小鼠 非结合性 WB Western Blot analysis of MYOC expression in transfected 293T cell line by MYOC monoclonal antibody (M02), clone 2B4. Lane 1: MYOC transfected lysate(57 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8至11个工作日
小鼠 非结合性 WB Western blot analysis of MYOC over-expressed 293 cell line, cotransfected with MYOC Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of MYOC expression in transfected 293T cell line by MYOC monoclonal antibody (M01), clone 4F8. Lane 1: MYOC transfected lysate(57 KDa). Lane 2: Non-transfected lysate. 50 μg Log in to see 8至11个工作日
Gibbon 非结合性 IHC, ELISA 0.05 mg Log in to see 2至3个工作日
小鼠 非结合性 IHC (p), RNAi, ELISA, WB Human Vessel: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7至9个工作日
非结合性 WB   200 μL Log in to see 13至14个工作日

通过反应活性、应用领域、克隆类型和共轭标记 MYOC 抗体

特性 应用范围 宿主 克隆类型 标记
Mouse (Murine)

Human , ,
, , , , ,
Rat (Rattus)



Mouse (Murine) Myocilin (MYOC) interaction partners

  1. mutant myocilin induces abnormal ECM (显示 MMRN1 抗体) accumulation in the ER of TM cells, which may be responsible for reduced outflow facility and IOP elevation in myocilin-associated glaucoma.

  2. Mutated myocilin and heterozygous Sod2 (显示 SOD2 抗体) deficiency act synergistically in a mouse model of open-angle glaucoma

  3. myocilin promotes cell proliferation and resistance to apoptosis via the ERK1/2 (显示 MAPK1/3 抗体) MAPK (显示 MAPK1 抗体) signaling pathway.

  4. Myocilin binds to ErbB2 (显示 ERBB2 抗体)/ErbB3 (显示 ERBB3 抗体), activates these receptors, and affects the downstream PI3K-AKT (显示 AKT1 抗体) signaling pathway

  5. Myocilin also stimulated osteogenic differentiation of wild-type MSCs, which was associated with activation of the p38 (显示 CRK 抗体), Erk1/2 (显示 MAPK1/3 抗体), and JNK (显示 MAPK8 抗体) MAP kinase (显示 MAPK1 抗体) signaling pathways

  6. We suggest that intracellular myocilin plays a role as a regulator of muscle hypertrophy pathways, acting through the components of dystrophin (显示 DMD 抗体) associated protein complex.

  7. The TIGR is implicated in resistance to oxidative stress. Despite the presence of a SOD motif, which is necessary for protection in mammalian cells, the protein is not a functional SOD, but might be involved in SOD activity.

  8. TIGR is a newly identified component of the CNS glial scar that is likely to contribute to neuronal regenerative failure characteristic of the mammalian CNS.

  9. Results do not support a causative role for increased MYOC levels or the MYOC gene in steroid-induced glaucoma.

  10. Results show that myocilin and gamma-synuclein interact and as a result, myocilin's properties are changed.

Human Myocilin (MYOC) interaction partners

  1. present work reveals that FOXC1 (显示 FOXC1 抗体) is an important regulator of exocytosis and establishes a new link between FOXC1 (显示 FOXC1 抗体) and MYOC-associated glaucoma

  2. The four detected MYOC mutations appeared to be associated with morphologic changes in the trabecular meshwork and the underlying pathogenesis of a subtype of familial primary open angle glaucoma.

  3. The mutations c.1456C < T (p.L486F) in MYOC and c.322G < A (p.V108I) in B4GALT3 (显示 B4GALT3 抗体) are likely responsible for the pathogenesis of Primary Open-angle Glaucoma in this family.

  4. Our findings demonstrated that MYOC cascade genetic testing for POAG allows identification of at-risk individuals at an early stage or even before signs of glaucoma are present. To our knowledge, this is the first study to demonstrate the clinical utility of predictive genetic testing for MYOC glaucoma.

  5. regulation by retinoic acid acts through the MYOC promoter which contains a critical cluster of four retinoic acid responsive (显示 GPRC5A 抗体) elements (RAREs), with the RARE-DR2 presenting the strongest effect and binding the RARalpha (显示 RARA 抗体)/RXRalpha (显示 RXRA 抗体) heterodimer.

  6. Five out of 30 families with PCG (16.7%) had disease attributable to CYP1B1 (显示 CYP1B1 抗体) alterations suggesting that CYP1B1 (显示 CYP1B1 抗体) is not the major gene causing PCG in Vietnamese unlike in the case of Arab or Romany patients.

  7. The present study provides insight into the genetic or haplotype variants of MYOC and OPTN (显示 OPTN 抗体) genes contributing to primary glaucoma. Haplotype variants identified in the present study may be regarded as potential contributing factors of primary glaucoma in Korea.

  8. Familial linkage studies for primary angle-closure glaucoma have been performed and identified MYOC causative primary angle-closure glaucoma disease

  9. The rate of CYP1B1 (显示 CYP1B1 抗体) mutations in Lebanese patients with primary congenital glaucoma (PCG) is lower than that reported in other Arab and Middle Eastern populations and suggests other genes are responsible.

  10. Data show that predictive genetic testing for early onset Myocilin glaucoma can facilitate early detection of disease or discharge from routine ophthalmic examinations.

Cow (Bovine) Myocilin (MYOC) interaction partners

  1. endoproteolytic processing might regulate the activity of myocilin; the inhibition of the processing by pathogenic mutations impairs the normal role of myocilin

Myocilin (MYOC) 抗原简介


MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.

Gene names and symbols associated with anti-Myocilin (MYOC) 抗体

  • myocilin (MYOC) 抗体
  • myocilin (myoc) 抗体
  • myocilin (Myoc) 抗体
  • AI957332 抗体
  • GLC1A 抗体
  • GPOA 抗体
  • JOAG 抗体
  • JOAG1 抗体
  • MGC136645 抗体
  • MYOC 抗体
  • myocilin 抗体
  • Tigr 抗体
  • zgc:136645 抗体

Protein level used designations for anti-Myocilin (MYOC) 抗体

myocilin , trabecular meshwork-induced glucocorticoid response protein , mutated trabecular meshwork-induced glucocorticoid response protein

397046 Sus scrofa
548602 Danio rerio
704406 Macaca mulatta
17926 Mus musculus
4653 Homo sapiens
81523 Rattus norvegicus
281342 Bos taurus
101087632 Felis catus
490344 Canis lupus familiaris
100008897 Oryctolagus cuniculus
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