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Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.. 再加上，我们可以发MLLT1 蛋白 (3)和数多这个蛋白质的别的产品。
Showing 10 out of 41 products:
Human Polyclonal MLLT1 Primary Antibody for ICC, IF - ABIN4334892
Perlman, Gadd, Arold, Radhakrishnan, Gerhard, Jennings, Huff, Guidry Auvil, Davidsen, Dome, Meerzaman, Hsu, Nguyen, Anderson, Ma, Mungall, Moore, Marra, Mullighan, Ma, Wheeler, Hampton et al.: MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours. ... in Nature communications 2015
Human Polyclonal MLLT1 Primary Antibody for WB - ABIN390126
Bitoun, Oliver, Davies: The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. in Human molecular genetics 2007
data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs in acute myeloid leukaemia, and suggest that displacement of ENL from chromatin may be a promising epigenetic therapy, alone or in combination with BET inhibitors, for aggressive leukaemia
MLL (显示 MLL 抗体)-ENL dysregulated the proliferative and repopulating capacity of hematopoietic stem cells.
Recurrent mutations within Wilms tumours involve the highly conserved YEATS domain of MLLT1.
Novel splice isoform of Mllt1 is documented and confirmed that both Mllt1 mRNA isoforms are translated. The data support that MLLT1 protein isoforms display distinct stage-specific expression during spermiogenesis and adult tissues.
Data suggest that AT mutated protein ATM (显示 ATM 抗体)-dependent phosphorylation of ENL (MLLT1) protein functions as switch from elongation to Polycomb (显示 CBX2 抗体)-mediated repression to preserve genome integrity.
AF9 and its homolog ENL directly interact with AF4.
MLL (显示 MLL 抗体)-ENL Interaction with CBX8 (显示 CBX8 抗体) Is Required for Efficient Transformation.
Data from a follow-up study in Rome suggest a particularly favorable prognosis for patients with acute lymphoblastic leukemia expressing the MLL (显示 MLL 抗体)/ENL fusion gene.
Three-way translocation involving MLL (显示 MLL 抗体), MLLT1, and a novel third partner, NRXN1 (显示 NRXN1 抗体), in a patient with acute lymphoblastic leukemia and t(2;19;11) (p12 (显示 POLE4 抗体);p13.3;q23).
ENL chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner.
define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL (显示 MLL 抗体)-mediated transformation of HPCs
demonstrate BAM11 transcriptional co-activation activity and its functional interaction with Btk (显示 BTK 抗体)
An intimate association between MLL (显示 MLL 抗体) and RNA pol II (显示 POLR2F 抗体) occurs at MLL (显示 MLL 抗体) target genes in vivo that is required for normal initiation and/or transcriptional elongation.
Overlapping expression of Af9 (显示 MLLT3 抗体) with Af4/Aff1 and Fmr2/Aff2 (显示 AFF2 抗体), two genes that are also related to neurodevelopmental diseases, as well as with the highly homologous Enl.
Even genetically complex leukemias can be reversed on inactivation of the initiating MLL (显示 MLL 抗体) fusion.
Capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells.
myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog
, myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog
, protein ENL
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1
, ENL/MLL fusion
, MLLT1/MLL fusion
, YEATS domain-containing protein 1
, leukemia-associated protein MLLT1
, myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog