anti-Milk Fat Globule-EGF Factor 8 Protein (MFGE8) 抗体

involved in the O-acetylation of GD3 ganglioside sialic acid [RGD, Feb 2006].. 再加上,我们可以发MFGE8 蛋白 (22)MFGE8 试剂盒 (19)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MFGE8 4240 Q08431
MFGE8 17304 P21956
MFGE8 25277 P70490
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antibodies-online.cn销售最多的anti-MFGE8 抗体

Showing 10 out of 167 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 IHC (p), WB Anti-Human Milk Fat Globule 1 antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue Anti-Human Milk Fat Globule 1 antibody, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant human MEGF8, 50.2KD (162aa tag+ S28-A317) Lane 1: Recombinant Human MEGF8 Protein 10ng  Lane 2: Recombinant Human MEGF8 Protein 5ng  Lane 3: Recombinant Human MEGF8 Protein 2.5ng  Lane 4: Recombinant Human MEGF8 Protein 1.25ng 100 μg 4至6个工作日
$280.00
详细
非结合性 WB Western blot analysis of MFG-E8 expression in A549 (A), NS-1 (B), PC12 (C) whole cell lysates. 200 μL 13至14个工作日
$487.50
详细
山羊 非结合性 ELISA, WB   100 μg 6至7个工作日
$429.87
详细
小鼠 仓鼠 非结合性 IHC (fro), WB 0.1 mg 6至8个工作日
$484.00
详细
大鼠 非结合性 ICC, IHC, WB Figure. DAB staining on IHC-P; Samples: Rat Testis Tissue. 100 μL 13至16个工作日
$253.00
详细
小鼠 仓鼠 非结合性 FACS, IP 0.1 mg 6至8个工作日
$484.00
详细
非结合性 EIA, FACS, WB Western blot analysis of  Lactadherin Antibody (C-term) in Hela cell line lysates (35ug/lane). Flow cytometric analysis of Hela cells using  Lactadherin Antibody (C-term) Cat.-No AP52057PU-N (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 0.4 mL 6至8个工作日
$522.50
详细
小鼠 非结合性 ICC, IHC, IHC (fro), IHC (p), WB Anti-MFGE8 / MFG-E8 antibody IHC staining of human placenta, trophoblast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN960988 concentration 10 ug/ml. Anti-MFGE8 / MFG-E8 antibody IHC of human placenta, trophoblast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μg 11至14个工作日
$484.00
详细
非结合性 ELISA, IHC, WB Western blot analysis of MFGE8 using HUVEC whole cell lysates ABIN6272659 at 1/100 staining Human Melanoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL 11至12个工作日
$390.77
详细
小鼠 非结合性 ELISA, IHC, IHC (p), IP, WB Anti-MFGE8 / MFG-E8 antibody IHC staining of human lung, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN961592 concentration 5 ug/ml. Anti-MFGE8 / MFG-E8 antibody IHC of human lung, epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11至14个工作日
$561.00
详细

引用最多的anti-MFGE8 抗体

  1. Human Monoclonal MFGE8 Primary Antibody for CyTOF, FACS - ABIN4899815 : Jinushi, Nakazaki, Carrasco, Draganov, Souders, Johnson, Mihm, Dranoff: Milk fat globule EGF-8 promotes melanoma progression through coordinated Akt and twist signaling in the tumor microenvironment. in Cancer research 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal MFGE8 Primary Antibody for IHC (p), WB - ABIN3044017 : Becker-Dreps, Choi, Stamper, Vilchez, Velasquez, Moon, Hudgens, Jiang, Permar: Innate Immune Factors in Mothers' Breast Milk and Their Lack of Association With Rotavirus Vaccine Immunogenicity in Nicaraguan Infants. in Journal of the Pediatric Infectious Diseases Society 2018 (PubMed)

  3. Human Monoclonal MFGE8 Primary Antibody for IHC (p), WB - ABIN535272 : Bártková, Rejthar, Bártek, Kovarík: Differentiation patterns of testicular germ-cell tumours as revealed by a panel of monoclonal antibodies. in Tumour biology 1987 (PubMed)
    Show all 2 Pubmed References

更多抗MFGE8的相互作用对抗体

Horse (Equine) Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. MFGE8 is expressed at the embryo- and fetal-maternal interface in equine pregnancy. In non-pregnant endometrium its expression was upregulated by oestrogen, a finding that was confirmed using endometrial explant culture. MFGE8 was expressed at similar levels by conceptuses collected 13 and 14 days after ovulation and by allantochorion sampled during the 5th month of gestation.

Human Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. Vasculopathy-induced dysfunction of pericytes and endothelial cells, the main cells secreting MFG-E8, may be associated with the decreased expression of MFG-E8 in systemic sclerosis (SSc) and that the deficient inhibitory regulation of latent TGFbeta-induced skin fibrosis by MFG-E8 may be involved in the pathogenesis of SSc and may be a therapeutic target for fibrosis in SSc patients.

  2. Our findings indicate that MFG-E8 may be a potential marker for poor prognosis and survival in breast cancer.

  3. Esophageal cancer patients with high MFG-E8 expression had worse overall survival and relapse-free survival in the subgroup with preoperative chemotherapy. The abundant MFG-E8 expression in esophageal squamous cell carcinoma might have a negative influence on the long-term survival of patients after chemotherapy by affecting T-cell regulation in the tumor microenvironment.

  4. MFGE8 polymorphisms were not associated with MetS but were related to DBP, HDL-C level, and WC in Chinese adults.

  5. This study showed for the first time that MFG-E8 expression is impaired in the endometrium of patients with endometriosis and infertility during the window of implantation.

  6. Our findings suggest that both MFGE8 and TGFbeta1 are agerelated inflammatory factors and are related to the degree of Atherosclerosis (AS). In conclusion, both MFGE8 and TGFbeta1 may serve as potential markers of the severity of AS

  7. Elevated serum MFG-E8 levels may be associated with cerebrovascular diseases or neuropsychiatric systemic lupus erythematosus.

  8. Circulating MFG-E8 levels are dramatically elevated in pregnancy, and are significantly higher in gestational diabetes mellitus than in normal pregnancy.

  9. MFG-E8 could be a potential novel prognostic marker for colorectal cancer (CRC) and overexpression of MFG-E8 might be involved in lymph node metastasis and angiogenesis of CRC.

  10. MFG-E8 levels are elevated in T2D but suppressed by increased adipose tissues, thereby allowing inflammatory factors to rise to high levels. MFG-E8 may serve as a potential biomarker for obesity and T2D in the clinical setting

  11. These findings provide a better understanding of the molecular mechanism underlying colorectal cancer progression and suggest a predictive role for MFG-E8 in colorectal cancer metastasis and prognosis

  12. Levels of MFGE8 were reduced in cirrhotic liver tissue from patients compared with controls.

  13. an efficient purification method for production of non-aggregated, full-length MFG-E8.

  14. Reduced serum milk fat globule-epidermal growth factor 8 (MFG-E8) concentrations are associated with an increased risk of microvascular complications in patients with type 2 diabetes.

  15. MFG-E8 is a protective factor in the pathogenesis of rheumatoid arthritis and subsequent bone loss.

  16. After myocardial infarction, Mfge8 (and Mertk)-expressing macrophages synergistically engage the clearance of injured cardiomyocytes.

  17. Studied the therapeutic effect of rhMFG-E8 in mouse models of IBD. Treatment with rhMFG-E8 significantly attenuated colitis in both models in a dose-dependent way.

  18. MFG-E8 promotes cutaneous wound healing by enhancing angiogenesis.

  19. Lactadherin may decrease inflammation by inhibiting secretory phospholipase A2 activity on pre-apoptotic leukemia cells.

  20. promotes tumor progression in oral squamous cell carcinoma

Cow (Bovine) Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. The vesicular environment provides optimal conditions for presentation and recognition of phosphatidylserine by lactadherin in a simple binding mechanism.

  2. lactophorin C-terminal fragment (LP16) and bovine milk fat globule membrane protein PAS6/7 strongly inhibited the replication of human rotavirus replication

  3. Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites.

  4. The number of lactadherin binding sites increased proportionally to the phosphatidylserine content over a range 0-2% and less rapidly for higher phosphatidylserine content

  5. The crystal structure of the bovine lactadherin C2 domain (residues 1 to 158) at 2.4 A, was determined.

  6. analysis of membrane-interactive loops of Lact-C2

  7. angiogenic endothelial cells have phagocytic properties for lactadherin-opsonized large particles and apoptotic cells

Mouse (Murine) Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. MFG-E8 promoted the proinflammatory phenotypic shift of aged VSMCs and arteries, rendering the vasculature prone to vascular diseases. MFG-E8 may constitute a novel therapeutic target for retarding the aging processes in such vessels.

  2. MFG-E8, as a candidate molecule to evaluate airway inflammation and remodeling, could be a potential target for the management and prevention of asthma exacerbations, suggesting that MFG-E8/integrin beta3 signaling may serve as a promising therapeutic agent for childhood asthma.

  3. Vasculopathy-induced dysfunction of pericytes and endothelial cells, the main cells secreting MFG-E8, may be associated with the decreased expression of MFG-E8 in systemic sclerosis (SSc) and that the deficient inhibitory regulation of latent TGFbeta-induced skin fibrosis by MFG-E8 may be involved in the pathogenesis of SSc and may be a therapeutic target for fibrosis in SSc patients.

  4. The loss of Mfge8 promotes radial-glia-like neural stem cells activation in the early postnatal dentate gyrus, resulting in a decreased number of label-retaining RGLs in adulthood.

  5. This study showed that MFG-E8 suppressed A1 astrocytes and holds great potential for the treatment of Alzheimer's disease.

  6. Letter: by stimulating SMC proliferation, MFGE8 promotes the formation of neointima possibly leading to hyperplasia and consequent stenosis upon arterial damage.

  7. Current study established the involvement of MFG-E8 in antioxidant effects during neuroinflammation.

  8. MFG-E8-/- B6 mice had IgG2c production against apoptotic cells and oxidized LDL. Apoptotic cell induced antibody responses depended on MyD88 signal and T cell help. In addition, MFG-E8-/- B6 mice had enlarged MZ B cell compartments as well as an enhanced antibody response to NP-Ficoll. A significant percentage of MZ B cells in aged MFG-E8-/- B6 mice migrated into follicles.

  9. Lactadherin, given at a single dose of 400 mug/kg 30 minutes before (preconditioning) or 30 minutes after cerebral fluid percussion injury, prevented coagulopathy as defined by clotting time, fibrinolysis, intravascular fibrin deposition, and microvascular bleeding of the lungs. Lactadherin also reduced cerebral edema, improved neurological function, and increased survival.

  10. study suggests that LPS represses MFG-E8 expression and disrupts enterocyte migration via a miR-99b dependent mechanism.

  11. Mesenchymal stem cell-derived MFG-E8 might accelerate diabetic wound healing by promoting angiogenesis, the clearance of apoptotic cells, and the infiltration of M2 macrophages, and by suppressing inflammatory cytokines in wound area.

  12. MFG-E8 localized to the basal lamina of the mammary gland during involution. Basal MFG-E8 localization promoted integrin-dependent suppression of beta-casein expression.

  13. MFG-E8 reduces neutrophil migration and neutrophil extracellular traps via downregulating surface CXCR2 expression in parallel with its role in the phagocytosis of apoptotic neutrophils.

  14. Mechanistically, ligation of alpha8beta1 by the milk protein Mfge8 reduces antral smooth muscle contractile force by preventing RhoA activation through a PTEN-dependent mechanism.

  15. MFG-E8 administration was associated with decreased inflammasome activation in the kidney. Adoptive transfer of MFG-E8-stimulated macrophages reduced activation of inflammasome and tissue damage. The protective role of MFG-E8 in ureteral obstruction kidney injury is mediated through anti-inflammatory macrophage reprogramming which results in decreased inflammasome activation, preventing severe tissue damage.

  16. characterization of the mechanisms by which macrophage derived MFG-E8 regulates wound inflammation; wound macrophage-derived MFG-E8 was recognized as a critical driver of wound angiogenesis

  17. MFG-E8 acts at two levels, by increasing VEGF and ET-1 expression in mesenchymal stromal cells (MSC) and by enhancing M2 polarization of macrophages, to increase tumor angiogenesis.

  18. MFGE8 is an anti-fibrotic protein in mesenchymal stem cell secretomes that strongly inhibits TGFbeta signaling and reduces extracellular matrix deposition and liver fibrosis in mice.

  19. an efficient purification method for production of non-aggregated, full-length MFG-E8.

  20. MFG-E8 is a protective factor in the pathogenesis of rheumatoid arthritis and subsequent bone loss.

Pig (Porcine) Milk Fat Globule-EGF Factor 8 Protein (MFGE8) interaction partners

  1. The evidence suggests that lactadherin and the other F4-binding milk proteins, together with other defense components of milk, could play a role in protection of neonatal piglets against ETEC induced diarrhea.

MFGE8 抗原简介

蛋白简介

involved in the O-acetylation of GD3 ganglioside sialic acid

Gene names and symbols associated with MFGE8

  • milk fat globule-EGF factor 8 protein (mfge8) 抗体
  • milk fat globule-EGF factor 8 protein (MFGE8) 抗体
  • milk fat globule-EGF factor 8 protein b (mfge8b) 抗体
  • milk fat globule-EGF factor 8 protein L homeolog (mfge8.L) 抗体
  • milk fat globule-EGF factor 8 protein (Mfge8) 抗体
  • AA408458 抗体
  • AGS 抗体
  • AI325141 抗体
  • BA46 抗体
  • EDIL1 抗体
  • HMFG 抗体
  • hP47 抗体
  • HsT19888 抗体
  • lactadherin 抗体
  • MFG-E8 抗体
  • mfge8 抗体
  • Mfgm 抗体
  • MFGME8 抗体
  • MFGMP-E8 抗体
  • MGC75581 抗体
  • MGC99228 抗体
  • MGC145109 抗体
  • OAcGD3S 抗体
  • P47 抗体
  • SED1 抗体
  • SPAG10 抗体
  • zgc:154157 抗体

Protein level used designations for MFGE8

milk fat globule-EGF factor 8 protein , sperm-membrane associated protein P47 , O-acetyl disialoganglioside synthase , breast epithelial antigen BA46 , lactadherin , medin , sperm associated antigen 10 , sperm surface protein hP47 , BP47 , MFG-E8 , MFGM , MGP57/53 , PAS-6/PAS-7 glycoprotein , SED1 , components 15/16 , sperm surface protein SP47 , EGF/factor VIII , MP47 , milk fat globule glycoprotein , O-acetyl GD3 ganglioside synthase , O-acetyltransferase Milk fat glolbule membrane protein , O-acetyltransferase milk fat globule membrane protein , milk fat globule EGF factor 8 protein , pP47 protein

GENE ID SPECIES
395038 Xenopus (Silurana) tropicalis
415494 Gallus gallus
453631 Pan troglodytes
488730 Canis lupus familiaris
558580 Danio rerio
735060 Xenopus laevis
100033943 Equus caballus
100585952 Nomascus leucogenys
4240 Homo sapiens
281913 Bos taurus
17304 Mus musculus
25277 Rattus norvegicus
100861394 Capra hircus
397545 Sus scrofa
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