anti-Melanoma Inhibitory Activity Family, Member 3 (MIA3) 抗体

Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. 再加上,我们可以发MIA3 蛋白 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MIA3 338366 Q8BI84
MIA3 375056 Q5JRA6
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Showing 10 out of 21 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 IF, IHC (p), WB Immunofluorescence analysis of methanol-fixed HepG2, using MIA3 antibody at 1:200 dilution. Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL 6至8个工作日
非结合性 ICC, IF, IHC (p), WB ICC/IF Image MIA3 antibody [N1], N-term detects MIA3 protein at Cytoplasm by immunofluorescent analysis. Sample: HepG2 cells were fixed in -20℃ 100% MeOH for 5 min. Green: MIA3 protein stained by MIA3 antibody [N1], N-term , diluted at 1:500. Blue: Hoechst 33343 staining. WB Image Sample (30 ug of whole cell lysate) 100 μL 3至4个工作日
非结合性 ELISA, WB Western blot analysis of MIA3 using Jurkat whole cell lysates 100 μL 11至12个工作日
非结合性 ICC, IF, IHC, IHC (p), WB Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL 11至14个工作日
非结合性 ELISA, WB   100 μL 11至13个工作日
非结合性 ICC, IF, IHC (p), WB 50 μL 12至14个工作日
非结合性 WB Western blot analysis MIA3 using Jurkat whole cell lysates. 100 μg 11至16个工作日
非结合性 WB   100 μL 2至3个工作日
非结合性 IF, IHC, WB   100 μL 2至3个工作日
非结合性 WB   50 μL 11至13个工作日


Fruit Fly (Drosophila melanogaster) Melanoma Inhibitory Activity Family, Member 3 (MIA3) interaction partners

  1. PGANT4 is an O-glycosyltransferase that functions as a regulator of secretion and secretory vesicle formation in vivo by glycosylating the essential Golgi/endoplasmic reticulum protein, Tango1 and conferring protection from furin-mediated proteolysis

  2. identifed a mechanism for polarized basement membrane(BM)secretion in follicle cells; BM proteins are synthesized in a basal ER compartment and exported through Tango1-positive ER exit sites to basal Golgi clusters; Crag targets Rab10 to structures in the basal cytoplasm, where it restricts protein delivery to the basal surface

  3. Study provides evidence that TANGO1 is an integral membrane protein localized to endoplasmic reticulum (ER) exit sites, with a luminal SH3 domain and a cytoplasmic proline-rich domain (PRD).

Mouse (Murine) Melanoma Inhibitory Activity Family, Member 3 (MIA3) interaction partners

  1. Mia3's role in protein secretion is much broader than previously realized, and it may, in fact, be required for the efficient secretion of all collagen molecules in higher organisms

  2. revealed very broad TANGO expression patterns in contrast to the highly restricted expression patterns previously determined for the other members of the MIA gene family

Human Melanoma Inhibitory Activity Family, Member 3 (MIA3) interaction partners

  1. These data showed that the NRZ tether is required for TANGO1 to assemble into a ring and indicated that stable complexes of TANGO1, cTAGE5 and TANGO1-short, recruit the tether.

  2. Both cTAGE5 and SEC12 were exported with TANGO1 in large COPII carriers.

  3. ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT and up-regulation of MIA3/TANGO1, thereby regulating endothelial cell functions directly relevant to atherosclerosis.

  4. TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats.

  5. Mammalian endoplasmic reticulum exit sites are organized by TANGO1 acting as a scaffold, in cooperation with Sec16 for efficient secretion.

  6. TANGO1 is thus pivotal in concentrating procollagen VII in the lumen and recruiting ERGIC membranes on the cytoplasmic surface of the endoplasmic reticulum.

  7. TANGO expression was strongly associated with tumour progression, nodal metastasis, clinical stage and number of blood or lymph vessels in oral squamous cell carcinoma.

  8. We conclude that SNP rs17465637 in MIA3 is indeed a genetic risk factor for CAD across different ethnic populations including Han Chinese.

  9. results suggest a potential association of the MIA3 rs17465637 with cardiovascular disease in dyslipidemic patients with rheumatoid arthritis

  10. genetic polymorphism is associated with an increased risk of myocardial infarction

  11. TANGO transfected cell lines revealed that TANGO expression reduces motility, whereas reduction of TANGO enhances migration.

  12. The results from this study present TANGO as a novel ligand for CD11c, regulating migratory processes of hematopoietic cells.

  13. Reduced expression of TANGO is associated with colon and hepatocellular carcinomas

MIA3 抗原简介


Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. May participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1 (By similarity).

Gene names and symbols associated with MIA3

  • Transport and Golgi organization 1 (Tango1) 抗体
  • MIA family member 3, ER export factor (MIA3) 抗体
  • melanoma inhibitory activity family, member 3 (MIA3) 抗体
  • melanoma inhibitory activity protein 3 (LOC100055507) 抗体
  • melanoma inhibitory activity family member 3 (mia3) 抗体
  • melanoma inhibitory activity 3 (Mia3) 抗体
  • 9130229H14Rik 抗体
  • A930039G15Rik 抗体
  • ARNT 抗体
  • AU022327 抗体
  • B230399H06Rik 抗体
  • C80126 抗体
  • CG11098 抗体
  • D320 抗体
  • Dmel\\CG11098 抗体
  • Gm1525 抗体
  • MIA3 抗体
  • TANGO 抗体
  • TANGO1 抗体
  • UNQ6077 抗体

Protein level used designations for MIA3

CG11098-PA , CG11098-PC , Tango1-PA , Tango1-PC , transport and golgi organisation 1 , transport and golgi organization 1 , melanoma inhibitory activity family, member 3 , melanoma inhibitory activity protein 3-like , melanoma inhibitory activity protein 3 , transport and Golgi organization protein 1 , C219 reactive peptide , C219-reactive peptide , TANGO1

33930 Drosophila melanogaster
421337 Gallus gallus
457757 Pan troglodytes
478997 Canis lupus familiaris
704405 Macaca mulatta
100024966 Monodelphis domestica
100055507 Equus caballus
100351527 Oryctolagus cuniculus
100379945 Xenopus (Silurana) tropicalis
100450028 Pongo abelii
100479797 Ailuropoda melanoleuca
100580164 Nomascus leucogenys
338366 Mus musculus
375056 Homo sapiens
509133 Bos taurus
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