Matrix Metallopeptidase 1 (Interstitial Collagenase) 蛋白 (MMP1)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. 再加上,我们可以发MMP1 抗体 (319)MMP1 试剂盒 (135)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
MMP1 4312 P03956
MMP1 17386 P33435
MMP1 300339  
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
人细胞 His tag 10 μg Log in to see 20至21个工作日
HEK-293 Cells His tag 50 μg Log in to see 2至3个工作日
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HEK-293 Cells His tag Validation with Western Blot 10 μg Log in to see 8至11个工作日
大肠杆菌(E. Coli) 非结合性 Validation with Western Blot 10 μg Log in to see 8至11个工作日
Human 非结合性 10 μg Log in to see 6至7个工作日
HEK-293 Cells His tag Validation with Western Blot 10 μg Log in to see 8至11个工作日
Mammalian Cells His tag   50 μg Log in to see 4 Days
大肠杆菌(E. Coli) His tag 100 μg Log in to see 13至16个工作日
HEK-293 Cells 非结合性   10 μg Log in to see 10至12个工作日

MMP1 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , , , , ,
, ,
Mouse (Murine)

Rat (Rattus)

引用最多的MMP1 蛋白

  1. Human MMP1 Protein expressed in Human Cells - ABIN2003013 : Desrochers, Jeffrey, Weiss: Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity. in The Journal of clinical investigation 1991 (PubMed)
    Show all 5 Pubmed References

更多Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1)互动伙伴

Human Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. study to explore the relationship between 2 polymorphisms (MMP-1-755 T/G [rs498186] and MMP-3 (显示 MMP3 蛋白) A/C [rs632478]) and disc degeneration; no significant association of the MMP-1 polymorphism with disc degeneration was found

  2. Expression of GSDMC is increased by UV irradiation in human skin keratinocytes. GSDMC induction contributes to the increase of MMP-1 expression specifically via activation of ERK (显示 EPHB2 蛋白) and JNK (显示 MAPK8 蛋白) pathways.

  3. our results suggest that the typical 1G/2G MMP-1 polymorphic site did not play a direct determinant role in breast cancer among Taiwanese women.

  4. The maternal and fetal 1G/1G MMP1 gene polymorphisms may be strong genetic markers of preeclampsia, occurring either individually or together.

  5. The current study indicated that MMP1 has a key role in the regulation of cervical tumor growth and lymph node metastasis via epithelial mesenchymal transition to a certain extent

  6. 2G allele of MMP-1, C allele of MMP-2 (显示 MMP2 蛋白) and 5A/6A genotype of MMP-3 (显示 MMP3 蛋白) are associated with susceptibility and disease progression of type 2 diabetic nephropathy

  7. this study provides insights into the development of a possible alternative therapy manipulating MMP-1 and the mTOR (显示 FRAP1 蛋白) signaling pathway in Epidermal growth factor receptor (显示 EGFR 蛋白)-tyrosine kinase (显示 RET 蛋白) inhibitor-resistant lung adenocarcinoma.

  8. Specific silencing that targeted AMPK (显示 PRKAA1 蛋白) resulted in the enhancement of mobility and contractility and in the production of MMP-1 and MMP-2 (显示 MMP2 蛋白).

  9. MMP-1 genotype may accelerate the development of HIV-associated neurocognitive disorder (HAND) whereas MMP3 (显示 MMP3 蛋白) -1612 5A5A genotype may reduce the risk of pathogenesis of HAND.

  10. Authors observed a significant increase in the immunoexpression of collagen I and III in patients with DCM and a significant reduction in the immunoexpression of MMP-1 compared with the control group. Also, the collagen I and TIMP-1 (显示 TIMP1 蛋白) expression indicated a positive linear correlation and respectively a negative linear relationship with collagen III and MMP-1.

Pig (Porcine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. the identification of MMP1 and MMP10 (显示 MMP10 蛋白) genes in swine is reported.

  2. increased interstitial MMP1 activity during ischemia and reperfusion is a result of the endothelin protein kinase c pathway and may be due to enhanced phosphorylation of mmp1

  3. Results indicate that leukemia inhibitory factor (LIF (显示 LIF 蛋白)) and Oncostatin M (显示 OSM 蛋白) increase the expression of MMP-1, MMP-3 (显示 MMP3 蛋白), and TIMP-1 (显示 TIMP1 蛋白) several fold, and that their expression is reduced to basal levels in the presence of the LIF (显示 LIF 蛋白) antagonist MH35-BD.

Fruit Fly (Drosophila melanogaster) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. results suggest that Ubx regulates organ shape by controlling Mmp1 expression, and the extent and timing of extracellular matrix degradation.

  2. This work identifies Draper-dependent activation of MMP-1 as a novel cascade required for proper glial clearance of severed axons.

  3. Mmp1 negatively regulates ectopic eye differentiation by restricting the rate of proliferation and the levels of expression of retinal-determining genes dachshund and eyes absent.

  4. Data indicate that matrix metalloproteinases mmp1 and mmp2 (显示 MMP2 蛋白) mutants have distinct heart phenotypes.

  5. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.

  6. A primary function of Mmp1, under the control of the JNK (显示 MAPK8 蛋白) pathway, is to promote basement membrane repair, which in turn may permit cell migration and the restoration of a continuous tissue.

  7. Drosophila Mmp1 is involved in the regulation of ISC proliferation for maintenance of gut (显示 GUSB 蛋白) homeostasis

  8. Study identified three genes, regeneration (rgn (显示 RGN 蛋白)), augmenter of liver regeneration (alr (显示 GFER 蛋白)) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration.

Mouse (Murine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. Infection with Mycobacterium bovis results in increase in interleukin-1alpha, TGF-beta1 (显示 TGFB1 蛋白), and MMP1 in multinucleated macrophages.

  2. MMP-2 (显示 MMP2 蛋白) promoted and MMP-13 (显示 MMP13 蛋白) disrupted vasculogenic mimicry formation in large cell lung cancer by cleaving laminin-5 to influence EGFR (显示 EGFR 蛋白) signal activation.

  3. The data demonstrate that MMP13 (显示 MMP13 蛋白) and CTGF (显示 CTGF 蛋白) play a crucial role in modulation of fibrogenic mediators while promoting hepatic fibrogenesis.

  4. CXCL10 (显示 CXCL10 蛋白) has strong inhibitory effects on neovascularization, whereas MMP13 (显示 MMP13 蛋白) is required for neovascularization in C. albicans-infected corneas.

  5. that MMP-13 (显示 MMP13 蛋白) is a central protease in infarct development and cortical remodeling during post-stroke neurorepair

  6. the phenotype seen in the Hdac4 (显示 HDAC5 蛋白)(-/-) mice is partially derived from elevation in MMP-13 (显示 MMP13 蛋白) and may be due to a bone remodeling disorder caused by overexpression of this enzyme.

  7. MEF2C (显示 MEF2C 蛋白) is necessary for Mmp13 (显示 MMP13 蛋白) gene expression at the transcriptional level and participates in PTH (显示 PTH 蛋白)-stimulated Mmp13 (显示 MMP13 蛋白) gene expression by increased binding to c-FOS at the AP-1 (显示 JUN 蛋白) site in the Mmp13 (显示 MMP13 蛋白) promoter.

  8. data reveal a novel involvement of MMP-13 (显示 MMP13 蛋白) in regulating dendritic cell (DC) immunobiology through moderating MHC-I surface presentation, endocytosis and cytokine/chemokine (显示 CCL1 蛋白) secretion; furthermore, the reduced MHC-I surface presentation by DCs resulted in a poor CD8 (显示 CD8A 蛋白)(+) T-cell response in vitro; MMP-13 (显示 MMP13 蛋白) might be a promising target for therapeutic intervention in inflammatory diseases

  9. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2 (显示 DDR2 蛋白)-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 (显示 DDR2 蛋白) and matrix metalloproteinase 13 (显示 MMP13 蛋白).

  10. Postnatal chondrocyte-specific deletion of Hdac3 (显示 HDAC3 蛋白) with an inducible Col2a1 (显示 COL2A1 蛋白)-Cre caused premature production of pErk1/2 and Mmp13 (显示 MMP13 蛋白) in the growth plate.

Cow (Bovine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. BoHV-4 infection affects various pathways related to cell proliferation and cell surface integrity, at least three of which were centered on upregulation of matrix metalloproteinase 1 (MMP1). MMP1 transcription was upregulated by the BoHV-4 transactivator IE2/RTA (显示 RBM9 蛋白), leading to abnormally high metalloproteinase tissue levels, potentially leading to defective endometrium healing and unresolved inflammation.

  2. The expression patterns of MMP1, MMP2 (显示 MMP2 蛋白), and MMP8 (显示 MMP8 蛋白) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2 (显示 MMP2 蛋白), and MMP8 (显示 MMP8 蛋白) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2 (显示 MMP2 蛋白), and MMP8 (显示 MMP8 蛋白) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.

  3. Data suggest that luteolytic factors (such as interferon gamma (显示 IFNG 蛋白), tumor necrosis factor alpha (显示 TNF 蛋白), and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

  4. The results showed that a decrease in MMP-1 and MMP-2 (显示 MMP2 蛋白) gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.

  5. Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.

  6. MMP-1 promotes VEGFR2 (显示 KDR 蛋白) expression and proliferation of endothelial cells through stimulation of PAR-1 (显示 F2R 蛋白) and activation of NF-kappaB (显示 NFKB1 蛋白)

  7. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

  8. the differential expression and localization of membrane-type 1 matrix metalloproteinase (显示 MMP14 蛋白) in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle,including activation of pro-MMP-2 (显示 MMP2 蛋白)

  9. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 and MMP-13 (显示 MMP13 蛋白) (follicular apex (显示 APEX1 蛋白) vs. base) for the preovulatory collagenolysis required for follicle rupture

  10. identification of MT1-MMP (显示 MMP14 蛋白) in odontoclasts during deciduous tooth resorption might be relevant to the migration activity that these cells have to gain access to the root surface

Rabbit Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. These results suggest that PEP-1-SIRT2 (显示 SIRT2 蛋白) promotes matrix metalloproteinases-induced dedifferentiation via ERK (显示 MAPK1 蛋白) signaling in articular chondrocytes. .

  2. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 and decreased TIMP-3 (显示 TIMP3 蛋白) secretion.

Horse (Equine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners

  1. ANXA2 (显示 ANXA2 蛋白) and MMP1 might participate in remodeling during wound healing in the horse.

  2. The polymorphism in the promoter of the MMP-1 gene could be a risk factor for early implant failure of total hip arthroplasty.

  3. These results suggest that MMP-1 and IL-8 (显示 IL8 蛋白) are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.

Xenopus laevis Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) interaction partners



Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with MMP1

  • matrix metallopeptidase 1 (MMP1)
  • Matrix metalloproteinase 1 (Mmp1)
  • matrix metalloproteinase 1 (RB11133)
  • matrix metalloproteinase 1 (Mmp1)
  • matrix metallopeptidase 13 (Mmp13)
  • matrix metallopeptidase 1 (interstitial collagenase) (MMP1)
  • matrix metallopeptidase 1 S homeolog (mmp1.S)
  • interstitial collagenase (LOC100727966)
  • matrix metallopeptidase 1 (Mmp1)
  • CG4859 蛋白
  • Clg 蛋白
  • Clgn 蛋白
  • col4 蛋白
  • dm1-MMP 蛋白
  • Dmel\\CG4859 蛋白
  • dmmp1 蛋白
  • l(2)k04809 蛋白
  • MMP-1 蛋白
  • MMP-13 蛋白
  • Mmp1 蛋白
  • Mmp 1 蛋白
  • Mmp1a 蛋白
  • mmp18 蛋白

Protein level used designations for MMP1

fibroblast collagenase , interstitial collagenase , matrix metalloprotease 1 , matrix metalloproteinase 1 , MMP-1 , matrix metalloproteinase 1 (type I collagenase) , matrix metalloproteinase-1 , CG4859-PC , CG4859-PD , CG4859-PE , CG4859-PF , CG4859-PG , CG4859-PH , CG4859-PI , CG4859-PJ , CG4859-PK , CG4859-PL , Mmp1-PC , Mmp1-PD , Mmp1-PE , Mmp1-PF , Mmp1-PG , Mmp1-PH , Mmp1-PI , Mmp1-PJ , Mmp1-PK , Mmp1-PL , Collagenase-3 , collagenase 3 , collagenase-1 , matrix metalloproteinase 13 , matrix metalloproteinase-13 , MMP-18 , collagenase-4 , matrix metalloproteinase-18 , xCol4 , matrix metallopeptidase 1a , matrix metalloproteinase 1a (interstitial collagenase) , myocardial collagenase

4312 Homo sapiens
397320 Sus scrofa
37949 Drosophila melanogaster
1790862 Rhodopirellula baltica SH 1
100144547 Bombyx mori
17386 Mus musculus
281308 Bos taurus
100009110 Oryctolagus cuniculus
489428 Canis lupus familiaris
100033896 Equus caballus
495287 Xenopus laevis
101120355 Ovis aries
100727966 Cavia porcellus
300339 Rattus norvegicus
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