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The product of MLX belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. 再加上，我们可以发MAX-Like Protein X 蛋白 (6)和数多这个蛋白质的别的产品。
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Human Polyclonal MLX Primary Antibody for ELISA, IHC - ABIN4334896
Stoltzman, Peterson, Breen, Muoio, Billin, Ayer: Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. in Proceedings of the National Academy of Sciences of the United States of America 2008
MLX promotes myogenesis not via an adjustment of glucose metabolism but rather by inducing the expression of several myokines, including insulin-like growth factor 2 (IGF2 (显示 IGF2 抗体))
Glucose is required at two additional steps to stimulate the transcription activation function of MondoA (显示 MLXIP 抗体)-Mlx complexes.
Overexpression of dominant negative Mlx improves glucose intolerance by inhibiting expression not only of lipogenic enzymes but also other important genes such as Glucose-6-phosphatase (显示 G6PC 抗体) and Elovl6 (显示 ELOVL6 抗体).
MYC (显示 MYC 抗体) is part of a network of bHLHLZ proteins centered on the MYC (显示 MYC 抗体) heterodimeric partner MAX and its counterpart, the MAX-like protein MLX.
Knockdown of MondoA (显示 MLXIP 抗体), or its dimerization partner Mlx, blocks Myc (显示 MYC 抗体)-induced reprogramming of multiple metabolic pathways, resulting in apoptosis
Data show that for both MondoA (显示 MLXIP 抗体) and Mlx, the C-terminal domain CRM-1 (显示 XPO1 抗体) has cytoplasmic localization activity that is required by the protein monomers to accumulate in the cytoplasm.
Mlx is an obligatory partner of ChREBP (显示 MLXIPL 抗体) in regulating lipogenic enzyme genes in liver.
Endogenous MondoA (显示 MLXIP 抗体) and Mlx associate with mitochondria in primary skeletal muscle.
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
MAX-like protein X
, transcription factor-like protein 4
, max-like protein X
, BigMax alpha
, MAX-like bHLHZIP protein
, protein BigMax
, transcription factor like 4
, transcription factor-like 4
, transcription factor max-like protein X
, BigMax protein
, class D basic helix-loop-helix protein 13
, max-like factor protein