anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) 抗体

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. 再加上,我们可以发MAD2L1 蛋白 (8)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
MAD2L1 4085 Q13257
MAD2L1 56150 Q9Z1B5
MAD2L1 297176  
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Showing 10 out of 148 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-MAD2L1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  MCF7 cell lysate 100 μL 2至3个工作日
$289.00
详细
山羊 非结合性 ELISA, WB   100 μg 6至7个工作日
$429.84
详细
非结合性 ICC, IF, IP, IHC (p), WB IHC-P Image MAD2L1 antibody [C2C3], C-term detects MAD2L1 protein at cytoplasm and nucleus in human A549 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded human A549 xenograft. MAD2L1 antibody [C2C3], C-term , diluted at 1:250. WB Image Sample (30μg whole cell lysate) A:Hep G2 , B:MOLT4 , C:Raji , 12% SDS PAGE antibody diluted at 1:1000 100 μL 3至4个工作日
$466.18
详细
非结合性 WB Anti- Mad2L1 Picoband antibody, Western blotting All lanes: Anti Mad2L1  at 0.5ug/ml Lane 1: 293T Whole Cell Lysate at 40ug Lane 2: COLO320 Whole Cell Lysate at 40ug Predicted bind size: 23KD Observed bind size: 23KD 100 μg 4至6个工作日
$240.00
详细
小鼠 非结合性 IHC (p), IP, WB IImmunohistochemistry of normal testis (formalin fixed) after antigen retreival, stained with Anti-Mad2L1 (clone 17D10)). Primary spermatocytes show staining of both the cytoplasm and nucleus. Picture kindly supplied by M.d.Espen Burum-Auensen from Rikshospitalet, Norway 50 μL 7至8个工作日
$447.65
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非结合性 EIA, WB   0.1 mg 4至8个工作日
$632.50
详细
非结合性 ELISA, ICC, IF, WB ABIN6275902 staining  A549 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11至12个工作日
$390.77
详细
非结合性 ELISA, ICC, IF, IHC, WB Western blot analysis of Hela whole cell lysates, using MAD2L1 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276825 staining  A549 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11至12个工作日
$390.77
详细
非结合性 IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL 11至14个工作日
$484.00
详细
非结合性 ELISA, IF, IHC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with MAD2L1 antibody ABIN214362 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-MAD2L1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11至14个工作日
$484.00
详细

引用最多的anti-MAD2L1 抗体

  1. Human Polyclonal MAD2L1 Primary Antibody for ICC, IF - ABIN151995 : Wu, Glickstein, Liu, Fujita, Li, Yang, Duvoisin, Wan: The anaphase-promoting complex coordinates initiation of lens differentiation. in Molecular biology of the cell 2007 (PubMed)
    Show all 13 Pubmed References

  2. Human Monoclonal MAD2L1 Primary Antibody for IHC (p), IP - ABIN108555 : Burum-Auensen, Deangelis, Schjølberg, Røislien, Andersen, Clausen: Spindle proteins Aurora A and BUB1B, but not Mad2, are aberrantly expressed in dysplastic mucosa of patients with longstanding ulcerative colitis. in Journal of clinical pathology 2007 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal MAD2L1 Primary Antibody for IHC (p), IP - ABIN108556 : Gysin, Paquette, McMahon: Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. in Molecular cancer research : MCR 2012 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal MAD2L1 Primary Antibody for WB - ABIN2801908 : Gemma, Hosoya, Seike, Uematsu, Kurimoto, Hibino, Yoshimura, Shibuya, Kudoh, Emi: Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers. in Lung cancer (Amsterdam, Netherlands) 2001 (PubMed)
    Show all 2 Pubmed References

  5. Human Polyclonal MAD2L1 Primary Antibody for ICC, IF - ABIN441319 : Itoh, Sugino, Ikeda, Mizuguchi, Kanno, Amin, Iemura, Yasui, Hirota, Tanaka: Nucleoporin Nup188 is required for chromosome alignment in mitosis. in Cancer science 2013 (PubMed)

  6. Human Polyclonal MAD2L1 Primary Antibody for ELISA, WB - ABIN268644 : Li, Benezra: Identification of a human mitotic checkpoint gene: hsMAD2. in Science (New York, N.Y.) 1996 (PubMed)

  7. Human Monoclonal MAD2L1 Primary Antibody for ELISA, WB - ABIN561710 : Yeh, Yeh, Chen, Juang: RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. in The Journal of biological chemistry 2012 (PubMed)

更多抗MAD2L1的相互作用对抗体

Human MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) interaction partners

  1. Low expression of BRCA1 and its transcriptional target MAD2 expression are strongly correlated with improved survival in high-grade serous carcinoma.

  2. study provides insights into how specific substrates are recruited to AAA+ ATPases (like TRIP13) through adaptor proteins and suggests a model of how translocation through the axial pore of AAA+ ATPases is coupled to protein remodelling

  3. MAD2 was found both in SCLC and NSCLC. Interestingly, there was a significant difference found between SCLC and NSCLC using qt-PCR (P<0.05).

  4. we demonstrate that the CDC20-MAD2 complex could also be formed independently of the SAC. Moreover, in prolonged arrest caused by nocodazole treatment, the overall levels of the CDC20-MAD2 complex are gradually, but significantly, reduced and this is associated with lower levels of cyclin B1, which brings a new insight into the mechanism of mitotic "slippage" of the arrested cells.

  5. MAD2-p31(comet) axis may serve as a potential therapeutic target for glioma.

  6. These results identify an unexpected dependency on TRIP13 in cells overexpressing Mad2.

  7. this study shows that MAD2L1 is a prognostic biomarker for lung adenocarcinoma

  8. MiR-200c-5p suppresses proliferation and metastasis of human hepatocellular carcinoma by suppressing MAD2L1 expression.

  9. Low MAD2L1 expression is associated with Chromophobe Renal Cell Carcinomas.

  10. TRAP1 is relevant in the control of key cell cycle regulators in tumor cells. TRAP1/TBP7 quality control of CDK1 and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.

  11. Thes authors show that p31(comet) binding to the TRIP13 N-terminal domain positions the disordered MAD2 N-terminus for engagement by the TRIP13 "pore loops", which then unfold MAD2 in the presence of ATP.

  12. catalytic activation of the spindle assembly checkpoint depends on regulated protein-protein interactions that accelerate the spontaneous but rate-limiting conversion of MAD2 required for mitotic checkpoint complex assembly

  13. in addition to its role in checkpoint signaling, MAD2 ensures chromosome stability through the regulation of AURORA B.

  14. Overexpression of MAD2gamma may play a role in checkpoint disruption and is associated with resistance to cisplatin-based chemotherapy in testicular germ cell tumors.

  15. Aberrant Mad2 expression was associated with cell proliferation and genetic instability, which may contribute to the carcinogenesis of PGI-DLBCL. Mad2 overexpression indicated a poor DFS.

  16. interactions between Mad2 and H3K4 regulate resolution of the spindle assembly checkpoint by limiting closed Mad2 availability for Cdc20 inhibition.

  17. we showed that BubR1 and Mad2 are overexpressed in oral squamous cell carcinoma cell lines and linked such overexpression to attenuated spindle assembly checkpoint activity.

  18. Studied the folding/unfolding process of the open and closed conformers of human Mad2.

  19. MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer

  20. p31comet-induced cell death is mediated by interactions with Mad2

Mouse (Murine) MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) interaction partners

  1. immunofluorescence staining for mitotic arrest deficient 2-like 1 and the protein kinase TTK, components of the spindle assembly checkpoint (SAC), suggested that this delay possibly involved SAC activation.

  2. Mad2-positive tumors have a higher frequency of developing persistent subclones that avoid remission and continue to grow.

  3. reduced MAD2 levels attenuate the apoptotic response to mis-segregating sex chromosomes and allow the formation of aneuploid sperm.

  4. p31comet-induced cell death is mediated by interactions with Mad2

  5. study shows that Mad2 is a novel substrate for CCP6 in megakaryocytes; Mad2 polyglutamylation plays a crucial role in the regulation of megakaryopoiesis

  6. Exacerbating chromosome missegregation in CENP-E+/- mice by reducing levels of another mitotic checkpoint component, Mad2, results in elevated cell death and decreased tumor formation compared with reduction of either protein alone.

  7. Mad2 is also repressed by p53 and its upregulation is required for chromosome instability in a p53 mutant tumor model

  8. Data show that Mad2 haploinsufficiency is protective in the presence of a cycle-specific DNA synthesis agent in vivo, and Ape1/Ref-1 inhibitor in vitro.

  9. Pcid2 is essential for B cell survival through the regulation of MAD2 expression during B cell differentiation

  10. tumours that experience transient Mad2 overexpression and consequent chromosome instability recur at markedly elevated rates

  11. a functional Mad2-dependent spindle checkpoint exists during the first meiotic division in mammalian oocytes

  12. Data show that the loss of Trrap leads to chromosome missegregation, mitotic exit failure and compromised mitotic checkpoints, which are caused by defective Trrap-mediated transcription of the mitotic checkpoint proteins Mad1 and Mad2.

  13. that Brca1(Delta11/Delta11) cells displayed decreased expression of a number of genes that are involved in the spindle checkpoint, including Mad2

  14. Data suggest that Mad2 and BubR1 must cooperate to inhibit Cdc20 activity.

  15. Our results provide further evidence for the role of MAD2 as a spindle checkpoint protein in mouse oocytes.

  16. Mad2 is involved in synergistic growth of immature hematopoietic progenitor cells in response to stem cell factor plus Granulocyte-Macrophage Colony-Stimulating Factor

MAD2L1 抗原简介

蛋白简介

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.

Gene names and symbols associated with MAD2L1

  • mitotic arrest deficient 2 like 1 (MAD2L1) 抗体
  • MAD2 mitotic arrest deficient-like 1 (Mad2l1) 抗体
  • MAD2 mitotic arrest deficient-like 1 (yeast) (MAD2L1) 抗体
  • MAD2 mitotic arrest deficient-like 1 (yeast) (mad2l1) 抗体
  • mitotic arrest deficient 2 like 1 (mad2l1) 抗体
  • mitotic arrest deficient 2 like 1 (Mad2l1) 抗体
  • mitotic arrest deficient 2 like 1 S homeolog (mad2l1.S) 抗体
  • AA673185 抗体
  • cb408 抗体
  • HSMAD2 抗体
  • mad2 抗体
  • MAD2L1 抗体
  • XMad2 抗体
  • zgc:112133 抗体

Protein level used designations for MAD2L1

MAD2 (mitotic arrest deficient, yeast, homolog)-like 1 , MAD2-like protein 1 , mitotic arrest deficient 2-like protein 1 , mitotic arrest deficient, yeast, homolog-like 1 , mitotic spindle assembly checkpoint protein MAD2A , MAD2 (mitotic arrest deficient, homolog)-like 1 , MAD2-like 1 , spindle assembly checkpoint protein Mad2 , MAD2 mitotic arrest deficient-like 1 , MAD2 mitotic arrest deficient-like 1 (yeast)

GENE ID SPECIES
4085 Homo sapiens
56150 Mus musculus
337870 Bos taurus
422675 Gallus gallus
461661 Pan troglodytes
476070 Canis lupus familiaris
550434 Danio rerio
708574 Macaca mulatta
100125170 Xenopus (Silurana) tropicalis
100137358 Papio anubis
100218172 Taeniopygia guttata
297176 Rattus norvegicus
380433 Xenopus laevis
100731050 Cavia porcellus
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