anti-Lysine (K)-Specific Demethylase 5B (KDM5B) 抗体

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. 再加上,我们可以发KDM5B 蛋白 (6)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
KDM5B 10765 Q9UGL1
KDM5B 75605 Q80Y84
KDM5B 304809  
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antibodies-online.cn销售最多的anti-KDM5B 抗体

Showing 10 out of 87 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 交付 价格 详细
非结合性 WB Western blot analysis of KDM5B expression in rat testis extract ( Lane 1), mouse testis extract ( Lane 2) and HEPG2 whole cell lysates ( Lane 3). KDM5B at 175KD was detected using rabbit anti- KDM5B Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 ??g/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg 4至6个工作日
小鼠 非结合性 ELISA, WB 50 μL 2至3个工作日
小鼠 非结合性 IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to KDM5B on formalin-fixed paraffin-embedded human colon. [antibody concentration 1 ug/ml] KDM5B monoclonal antibody (M02), clone 1G10. Western Blot analysis of KDM5B expression in Hela NE . (170kD,OMIM, 100 μg 11至12个工作日
小鼠 非结合性 ELISA, WB KDM5B monoclonal antibody (M02A), clone 1G10. Western Blot analysis of KDM5B expression in Hela NE . (170kD,OMIM, KDM5B monoclonal antibody (M02A), clone 1G10. Western Blot analysis of KDM5B expression in NIH/3T3 200 μL 11至12个工作日
小鼠 非结合性 IF, ELISA, WB 100 μg 11至14个工作日
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-KDM5B/PLU1/Jarid1B Polyclonal Antibody, Unconjugated (ABIN762986) at 1:200 followed by conjugation to the secondary antibody and DAB staining Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat Anti-Rabbit IgG at 1: 5000;  TMB staining; Read the data in Microplate Reader by 450nm 100 μL 3至7个工作日
小鼠 非结合性 WB Western blot analysis in mouse testis tissue lysates (35ug/lane). 400 μL 2至3个工作日
非结合性 IHC, WB Western blot analysis of extracts of HeLa cell line, using KDM5B antibody. Western blot analysis of extracts of various cell lines, using KDM5B antibody (ABIN2737048) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s. 100 μL 11至13个工作日
小鼠 非结合性 Fig. 1. Black line: Control Antigen (100 ng) 100 μg 11至16个工作日
小鼠 非结合性 ELISA, WB Western Blot detection against Immunogen (35.9 KDa) . 50 μL 11至12个工作日

引用最多的anti-KDM5B 抗体

  1. Human Polyclonal KDM5B Primary Antibody for IHC, IHC (p) - ABIN4332094 : Wouters, Stas, Gremeaux, Govaere, Van den Broeck, Maes, Agostinis, Roskams, van den Oord, Vankelecom: The human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis. in PLoS ONE 2013 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal KDM5B Primary Antibody for ICC, IF - ABIN438013 : Roesch, Vultur, Bogeski, Wang, Zimmermann, Speicher, Körbel, Laschke, Gimotty, Philipp, Krause, Pätzold, Villanueva, Krepler, Fukunaga-Kalabis, Hoth, Bastian, Vogt, Herlyn: Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells. in Cancer cell 2013 (PubMed)
    Show all 6 Pubmed References

  3. Human Monoclonal KDM5B Primary Antibody for IF, IHC (p) - ABIN1327126 : Xiang, Zhu, Han, Ye, Xu, Peng, Ma, Yu, Lin, Chen, Chen: JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal KDM5B Primary Antibody for FACS, ICC - ABIN4332096 : Croteau, Jenkins, Ye, Mullins, Brinckerhoff: Differential mechanisms of tumor progression in clones from a single heterogeneous human melanoma. in Journal of cellular physiology 2013 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal KDM5B Primary Antibody for ELISA, WB - ABIN524185 : Bamodu, Huang, Lee, Wu, Wang, Hsiao, Yeh, Chao: Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448. in BMC cancer 2016 (PubMed)
    Show all 2 Pubmed References

  6. Human Monoclonal KDM5B Primary Antibody for ELISA, WB - ABIN524186 : Hayami, Yoshimatsu, Veerakumarasivam, Unoki, Iwai, Tsunoda, Field, Kelly, Neal, Yamaue, Ponder, Nakamura, Hamamoto: Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. in Molecular cancer 2010 (PubMed)


Human Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. Down-regulation of JARID1B by shRNA inhibited leukemia cell proliferation, promoted apoptosis, and blocked cell cycle in G0/G1 phase through histone H3K4 methylation.

  2. Jarid1b negatively regulated Ship1 expression, but not that of Pten, by directly binding to its promoter to modulate H3K4me3 enrichment.

  3. Findings indicate the importance of cellular phenotypic heterogeneity in therapeutic resistance and identify lysine demethylase 5A/B (KDM5A/B) as key regulators of this process.

  4. This study documents that long-term, moderate hypoxia promotes resistance to the EGFR TKI, gefitinib, in the NSCLC cell line HCC827, which harbors an activating EGFR mutation..Mechanistically, knockdown of LSD1 and PLU-1, prevented and reversed hypoxia-induced gefitinib resistance, suggesting that LSD1 and PLU-1 play key roles in hypoxia-induced gefitinib resistance and epithelial-mesenchymal transition

  5. Results showed that JARID1B was overexpressed in non-small cell lung cancer (NSCLC) cells and its overexpression was associated with tumor size, lymph node metastasis, advanced stages, and poor overall survival in NSCLC patients. JARID1B mediated promotion of EMT and CSCs characteristics in NSCLC cells, suggesting that JARID1B can be a putative marker of tumor progression and poor prognosis in NSCLC patients.

  6. KDM5 inhibition has potential in the treatment of HER2(+) breast cancer.

  7. These results enlighten an important role of a miRNA's circuit in regulating JARID1B's activity and suggest new perspectives for epigenetic therapies.

  8. High JARID1B expression is associated with Osteosarcoma.

  9. In the HCC cell line, Hep3B, KDM5B expression promoted promote tumor cell proliferation and colony formation. Increased expression of KDM5B in HCC tissues, compared with adjacent normal liver tissues, and was associated with larger tumor size, advanced TNM stage, and reduced overall survival in patients with HCC.

  10. Data reinforces the recent observation that the KDM5B haploinsufficiency is not a mechanism involved in intellectual disability and that KDM5B disorder associated with loss of heterozygosity variants is a recessive disorder.

  11. Altered splicing of JARID1B may be important factor increasing melanoma aggressiveness.

  12. both KDM5A and KDM5B are involved in the lengthening of DICER1

  13. HBx activates the histone demethylase KDM5B and induces hepatic progenitor cell-like features in hepatocellular carcinoma

  14. JARID1B directly bound to PI3K/AKT signaling inhibitor SHIP1 gene promoter and decreased SHIP1 gene expression.

  15. We established the function of JARID1B in mediating the cancer stem cell potential of G0-like cells and our results expand understanding of its context-specific roles in malignant and normal stem cell homeostasis

  16. KDM5B is up-regulated in esophageal squamous cell carcinoma cells.MiR-194 targets KDM5B to inhibit esophageal squamous cell carcinoma development and progression.

  17. Study identified USP15 as having recurrent de novo loss of function mutations and discovered evidence supporting two other known genes with recurrent de novo variants (FOXP1 and KDM5B).

  18. research suggests that miR424-5p may act as a novel anti-oncogene in cervical cancer by blocking cell growth through targeting KDM5B-Notch pathway

  19. JARID1B is involved in the pathogenesis of glioma.

  20. PLU-1 was overexpressed in colorectal cancer tissue compared with healthy colon. PLU-1 expression positively correlated with colorectal cancer progression.

Mouse (Murine) Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. KDM5B regulates nucleosome positioning in embryonic stem cells.

  2. JARID1B bound to NFkB promoter and affected NFkB expression, resulting in the up-regulation of VEGF-A, promoting proliferation and migration of pulmonary arterial smooth muscle cells in mice with chronic hypoxia-induced pulmonary hypertension.

  3. KDM5B, which demethylates H3K4me3, plays an integral role in regulating RNAPII occupancy, transcriptional initiation and elongation, and alternative splicing events in embryonic stem cells.

  4. data suggest Kdm5b negatively regulates neurogenesis and represses reelin in neural stem cells from the adult subventricular zone.

  5. These results suggest that KDM5B acts to repress type I IFN and other innate cytokines to promote an altered immune response following Respiratory syncytial virus infection that contributes to development of chronic disease.

  6. findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of DR

  7. Deletion of Jarid1b compromises hematopoietic stem cell (HSC) self-renewal capacity; Jarid1b is a positive regulator of HSC potential.

  8. Mechanistically, JARID1B was required for GATA3 recruitment to the Foxa1 promoter to activate Foxa1 expression.

  9. KDM5B is a barrier to the reprogramming process as evidenced by the accelerated reprogramming of differentiated cells in the absence of Kdm5b.

  10. these studies identified Jarid1b as a negative regulator of hematopoietic stem cell (HSC) activity and Jhdmlf as a positive regulator of HSC activity.

  11. Results suggest a role for Jarid1b in Rb-mediated repression of cell cycle genes during senescence.

  12. results delineate an essential role for Jarid1b-mediated transcriptional control during embryonic stem cell differentiation

  13. The present study demonstrated a functional contribution of PLU1 overexpression with concomitant epigenetic dysregulation in cancer progression.

  14. PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells.

  15. Regions upstream of the promoter repress transcription more effectively in a non-malignant breast cell line as compared to breast cancer cell lines.

  16. Ectopic overexpression of mouse Jarid1B, a Yjr119Cp homolog, greatly diminished H3-(lysine) K4me3 and H3-K4me2 in HeLa cells, suggesting these proteins function as K4 demethylases in vivo.

  17. JARID1b blocks differentiation of multiple lineages from ES cells

Cow (Bovine) Lysine (K)-Specific Demethylase 5B (KDM5B) interaction partners

  1. Histone demethylases KDM3A, KDM4A, and KDM4C were expressed before and after embryonic genome activation, whereas KDM5B was mainly expressed during the blastocyst period.

KDM5B 抗原简介


Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor (By similarity).

Gene names and symbols associated with KDM5B

  • lysine (K)-specific demethylase 5Ba (kdm5ba) 抗体
  • lysine (K)-specific demethylase 5Bb (kdm5bb) 抗体
  • lysine demethylase 5B (KDM5B) 抗体
  • lysine (K)-specific demethylase 5B (Kdm5b) 抗体
  • lysine (K)-specific demethylase 5B (KDM5B) 抗体
  • lysine demethylase 5B (Kdm5b) 抗体
  • 2010009J12Rik 抗体
  • 2210016I17Rik 抗体
  • AW556288 抗体
  • cb264 抗体
  • CT31 抗体
  • D1Ertd202e 抗体
  • id:ibd5050 抗体
  • Jarid1b 抗体
  • jarid1ba 抗体
  • jarid1bb 抗体
  • mKIAA4034 抗体
  • PLU-1 抗体
  • Plu1 抗体
  • PUT1 抗体
  • Rb-Bp2 抗体
  • RBBP2H1A 抗体
  • RGD1565602 抗体
  • wu:fc44h11 抗体
  • wu:fd15c05 抗体
  • zgc:85741 抗体

Protein level used designations for KDM5B

jumonji, AT rich interactive domain 1B (Rbp2 like) , jumonji, AT rich interactive domain 1Ba (Rbp2 like) , histone demethylase JARID1B-B , jumonji/ARID domain-containing protein 1B-B , lysine-specific demethylase 5B-B , putative DNA/chromatin binding motif , lysine (K)-specific demethylase 5B , Jumonji, AT rich interactive domain 1B (RBP2-like) , jumonji, AT rich interactive domain 1B , lysine-specific demethylase 5B-like , RBP2-H1 , cancer/testis antigen 31 , histone demethylase JARID1B , jumonji/ARID domain-containing protein 1B , lysine-specific demethylase 5B , retinoblastoma-binding protein 2 homolog 1 , retinoblastoma-binding protein 2, homolog 1A , putative DNA/chromatin binding motif 1

327168 Danio rerio
415256 Danio rerio
457630 Pan troglodytes
100011885 Monodelphis domestica
100064707 Equus caballus
100077577 Ornithorhynchus anatinus
100356218 Oryctolagus cuniculus
100483283 Ailuropoda melanoleuca
10765 Homo sapiens
75605 Mus musculus
421168 Gallus gallus
479999 Canis lupus familiaris
100625438 Sus scrofa
540633 Bos taurus
304809 Rattus norvegicus
100723111 Cavia porcellus
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