LIM and Senescent Cell Antigen-Like Domains 1 蛋白 (LIMS1)

The protein encoded by LIMS1 is an adaptor protein which contains five LIM domains, or double zinc fingers. 再加上,我们可以发LIM and Senescent Cell Antigen-Like Domains 1 抗体 (68)LIM and Senescent Cell Antigen-Like Domains 1 试剂盒 (1)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
LIMS1 3987 P48059
大鼠 LIMS1 LIMS1 499443  
LIMS1 110829 Q99JW4
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
大肠杆菌(E. Coli) His tag,T7 tag 100 μg Log in to see 15至18个工作日
小麦胚 GST tag 10 μg Log in to see 11至12个工作日

LIMS1 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

更多LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1)互动伙伴

Human LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) interaction partners

  1. High LIMS1 expression is associated with Neuroblastoma.

  2. focal adhesion signaling to actin cytoskeleton is implicated in human laryngeal carcinogenesis and PINCH1 has prognostic significance in the disease.

  3. that PINCH-1 may be playing an important role in etiopathogenesis of both subtypes breast cancer

  4. Mammalian cells have two functional PINCH proteins, PINCH1 and PINCH2. PINCH not only binds to Nck2 and engages in the signaling of growth factor receptors, but also forms a ternary complex with ILK and parvin (IPP complex).

  5. our data suggest an essential role of PINCH1, ILK and ILKAP for the radioresistance of p53-wildtype glioblastoma multiforme cells

  6. Data suggest that PINCH1 and Nck2 critically participate in the regulation of cellular radiosensitivity and EGFR function and downstream signaling in a cellular model of human squamous cell carcinoma.

  7. Downregulation of PINCH1 is associated with metastatic breast cancer.

  8. changes in CSF levels of PINCH appear to correlate with changes in blood CD4 count and with changes in CSF hyperphosphorylated Tau levels

  9. two novel genes, galectin 9 and PINCH, were expressed at much higher levels in cancerous lesions than in normal tissues in all the patients with clear-cell carcinoma who were examined

  10. PINCH predicts survival in rectal cancer patients with RT, but not in patients without RT. The expression of PINCH may be regulated by radiation and by environmental factors surrounding the cells.

  11. PINCH is increased and binds to hp-Tau. These studies address a new mechanism by which AD and HIV may intersect and identify PINCH as a contributing factor to the accumulation of hyperphosphorylated Tau.

  12. Pinch-1 mRNA and protein were significantly up-regulated in acute lymphoblastic leukemia and acute myeloid leukemia bone marrow stromal cells compared to normal bone marrow stromal cells (p<0.01).

  13. PINCH protein might play an important role in the tumourigenesis and metastasis of gastric adenocarcinoma.

  14. PINCH mRNA overexpression in colorectal carcinomas is correlated with VEGF and FAS mRNA expression

  15. PINCH may function as a neuron-specific host-mediated response to challenge by HIV-related factors in the CNS.

  16. PINCH1 can shuttle into the nucleus from cytoplasm in podocytes, wherein it interacts with WT1 and suppresses podocyte-specific gene expression.

  17. Review provides an overview of the current knowledge of the molecular interactions of PINCH with other components of focal adhesions and discusses its potential implication for human heart disease.

  18. data reveal how specific domains of PINCH-1 direct two independent pathways: one utilizing ILK to allow cell attachment, and the other recruiting Rsu-1 to activate Rac1 in order to promote cell spreading

  19. PINCH staining at the tumour invasive margin was related to survival in poorly differentiated tumours but not in better differentiated tumours, indicating that the impact of PINCH on prognosis was dependent on differentiation status.

  20. Data suggest that the adapter protein PINCH1 critically participates in the regulation of the cellular radiosensitivity of normal and malignant cells similarly under adhesion and suspension conditions.

蛋白简介LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1)


The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with LIMS1

  • LIM zinc finger domain containing 1 (LIMS1)
  • LIM zinc finger domain containing 1 (Lims1)
  • LIM and senescent cell antigen-like domains 1 (Lims1)
  • 2310016J22Rik 蛋白
  • 4921524A02Rik 蛋白
  • AI507642 蛋白
  • AU021743 蛋白
  • AW551584 蛋白
  • C430041B13Rik 蛋白
  • Lims1l 蛋白
  • LIMS3 蛋白
  • LIMS3L 蛋白
  • PINCH 蛋白
  • PINCH-1 蛋白
  • Pinch1 蛋白
  • RGD1560732 蛋白

Protein level used designations for LIMS1

LIM and senescent cell antigen-like-containing domain protein 1 , particularly interesting new Cys-His protein 1 , renal carcinoma antigen NY-REN-48

3987 Homo sapiens
499443 Rattus norvegicus
414880 Gallus gallus
474540 Canis lupus familiaris
100511559 Sus scrofa
540281 Bos taurus
110829 Mus musculus
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