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The protein encoded by LIMS1 is an adaptor protein which contains five LIM domains, or double zinc fingers. 再加上，我们可以发LIM and Senescent Cell Antigen-Like Domains 1 蛋白 (5) 和 LIM and Senescent Cell Antigen-Like Domains 1 试剂盒 (1)和数多这个蛋白质的别的产品。
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Chicken Monoclonal LIMS1 Primary Antibody for IF, WB - ABIN968921
Campana, Myers, Rearden: Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury. in Glia 2003
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Human Monoclonal LIMS1 Primary Antibody for ICC, FACS - ABIN969354
Chiswell, Zhang, Murphy, Boggon, Calderwood: The structural basis of integrin-linked kinase-PINCH interactions. in Proceedings of the National Academy of Sciences of the United States of America 2008
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Human Monoclonal LIMS1 Primary Antibody for FACS, IF - ABIN966832
Yang, Wang, Hawkins, Chen, Vaynberg, Mao, Tu, Zuo, Wang, Wang, Wu, Tjandra, Qin: Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. in The Journal of biological chemistry 2009
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High LIMS1 expression is associated with Neuroblastoma (显示 ARHGEF16 抗体).
focal adhesion signaling to actin cytoskeleton is implicated in human laryngeal carcinogenesis and PINCH1 has prognostic significance in the disease.
that PINCH-1 may be playing an important role in etiopathogenesis of both subtypes breast cancer
Mammalian cells have two functional PINCH proteins, PINCH1 and PINCH2 (显示 LIMS2 抗体). PINCH not only binds to Nck2 (显示 NCK2 抗体) and engages in the signaling of growth factor receptors, but also forms a ternary complex with ILK (显示 ILK 抗体) and parvin (显示 PARVA 抗体) (IPP (显示 IPP 抗体) complex).
our data suggest an essential role of PINCH1, ILK (显示 ILK 抗体) and ILKAP (显示 ILKAP 抗体) for the radioresistance of p53 (显示 TP53 抗体)-wildtype glioblastoma multiforme cells
Data suggest that PINCH1 and Nck2 (显示 NCK2 抗体) critically participate in the regulation of cellular radiosensitivity and EGFR (显示 EGFR 抗体) function and downstream signaling in a cellular model of human squamous cell carcinoma.
Downregulation of PINCH1 is associated with metastatic breast cancer.
changes in CSF (显示 CSF2 抗体) levels of PINCH appear to correlate with changes in blood CD4 (显示 CD4 抗体) count and with changes in CSF (显示 CSF2 抗体) hyperphosphorylated Tau levels
two novel genes, galectin 9 (显示 LGALS9 抗体) and PINCH, were expressed at much higher levels in cancerous lesions than in normal tissues in all the patients with clear-cell carcinoma who were examined
PINCH predicts survival in rectal cancer patients with RT, but not in patients without RT. The expression of PINCH may be regulated by radiation and by environmental factors surrounding the cells.
findings suggest that PINCH-1 regulates integrin-mediated adhesion of keratinocytes through the interactions with ILK (显示 ILK 抗体) as well as EPLIN (显示 LIMA1 抗体).
Rsu-1 (显示 RSU1 抗体) expression is dramatically decreased in PINCH double knockout mouse livers.
PINCH is increased and binds to hp-Tau. These studies address a new mechanism by which AD and HIV may intersect and identify PINCH as a contributing factor to the accumulation of hyperphosphorylated Tau.
PINCH-1 inhibits JNK (显示 MAPK8 抗体)-mediated apoptosis by stabilising the PINCH-1 binding protein RSU-1 (显示 RSU1 抗体) and promotes Bcl-2 (显示 BCL2 抗体)-dependent pro-survival signalling downstream of integrins.
Data suggest that the adapter protein (显示 GRB10 抗体) PINCH1 critically participates in the regulation of the cellular radiosensitivity of normal and malignant cells similarly under adhesion and suspension conditions.
PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes.
These results provide important evidence for a crucial role of the PINCH-1-ILK (显示 ILK 抗体)-alpha-parvin (显示 PARVA 抗体) complex in the control of podocyte adhesion, morphology, and survival.
LIM (显示 PDLIM5 抗体) 5 domain of PINCH1 interacts with Rsu-1 (显示 RSU1 抗体) in mammalian cells and functions, in part, by altering cell adhesion.
The PINCH1 is composed of 5 LIM domains, binds ILK and locates to integrin-mediated adhesion sites, and PINCH1 is for integrin function, actin organization, cell-cell adhesion and endodermal cell survival during the implanting of mouse embryos.
PICH1, Ilk (显示 ILK 抗体) and alpha-parvin (显示 PARVA 抗体) form a complex to costameres in neonatal mouse ventricular myocytes. This complex is stimulated by fibronectins and phenylephrine, and by both by drug synergism, to regulate cardiac myocyte hypertrophy.
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
LIM and senescent cell antigen-like-containing domain protein 1
, particularly interesting new Cys-His protein 1
, renal carcinoma antigen NY-REN-48