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KCNIP3 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. 再加上，我们可以发Kv Channel Interacting Protein 3, Calsenilin 蛋白 (12) 和 Kv Channel Interacting Protein 3, Calsenilin 试剂盒 (10)和数多这个蛋白质的别的产品。
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Mammalian Monoclonal KCNIP3 Primary Antibody for ISt, IHC - ABIN1304731
Menegola, Trimmer: Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
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Cow (Bovine) Polyclonal KCNIP3 Primary Antibody for IHC, WB - ABIN2777506
Zaidi, Thomson, Choi, Buxbaum, Wasco: Intracellular calcium modulates the nuclear translocation of calsenilin. in Journal of neurochemistry 2004
Show all 2 Pubmed References
Human Polyclonal KCNIP3 Primary Antibody for ELISA, WB - ABIN4287519
Rivas, Mellström, Torres, Cali, Ferrara, Terracciano, Zannini, Morreale de Escobar, Naranjo: The DREAM protein is associated with thyroid enlargement and nodular development. in Molecular endocrinology (Baltimore, Md.) 2009
targeting SmgGDS (显示 RAP1GDS1 抗体) induces nucleolar stress, resulting in profound loss of DREAM target gene expression required for G1, S and G2 progression, and ultimately resulting in cell cycle arrest.
Disruption of DREAM and RB-E2F (显示 E2F1 抗体) complexes by oncoproteins from DNA tumor viruses leads to upregulation of cell cycle genes and impairs growth-inhibiting pathways, including the p53 (显示 TP53 抗体)-mediated downregulation of cell cycle genes. [review]
This study shows the application of hydrogen-deuterium exchange mass spectrometry and site-directed mutagenesis to investigate the Ca(2 (显示 CA2 抗体)+) binding properties and the subsequent conformational changes of full-length DREAM. EF-hands undergo large conformation changes upon calcium binding even though the EF-1 (显示 EEF1D 抗体) hand is not capable of binding to Ca(2 (显示 CA2 抗体)+).
Our approach yields high confidence ranked target gene maps for TP53 (显示 TP53 抗体), DREAM, MMB-FOXM1 (显示 FOXM1 抗体) and RB-E2F (显示 E2F1 抗体) and enables prediction and distinction of CC regulation. A web-based atlas at www.targetgenereg.org enables assessing the regulation of any human gene of interest.
downregulation of these genes through the p53 (显示 TP53 抗体)-p21 (显示 CDKN1A 抗体)-DREAM-CDE/CHR pathway appears to be a principal mechanism for G2/M cell cycle arrest by p53 (显示 TP53 抗体).
Our results support the hypothesis that KChIPs enhances Kv4.2 (显示 KCND2 抗体) functional expression by a 1 : 1 suppression of the N-terminal FERN domain and by producing additional positive regulatory effects on functional channel expression.
GCM1 (显示 GCM1 抗体)-directed villous trophoblast differentiation is repressed by DREAM
p53 (显示 TP53 抗体) can repress transcription of cell cycle genes through a p21(WAF1/CIP1 (显示 CDKN1A 抗体))-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements.
The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.
expression of calsenilin leads to a disruption of presenilin 1 (显示 PSEN1 抗体)/gamma-secretase-mediated epsilon-cleavage of N-cadherin (显示 CDH2 抗体), which results in the significant accumulation of N-cadherin (显示 CDH2 抗体) C-terminal fragment 1
Genome-wide analysis of trigeminal neurons in daDREAM transgenic mice identified cathepsin L (显示 CTSL1 抗体) and the monoglyceride lipase (显示 MGLL 抗体) as two new DREAM transcriptional targets related to pain.
association of PS1 (显示 PSEN1 抗体) carboxyl peptide (residues 445-467, HL9 (显示 DDC 抗体)) with DREAM is calcium dependent and stabilized by a cluster of three aromatic residues: F462 and F465 from PS1 (显示 PSEN1 抗体) and F252 from DREAM.
The association of calcium-bound calmodulin (CaM) with DREAM is mediated by a short amphipathic amino acid sequence located between residues 29 and 44 on DREAM.
The protein DREAM decreases development of L-DOPA-induced dyskinesia in mice and reduces L-DOPA-induced expression of FosB (显示 FOSB 抗体), phosphoacetylated histone H3 (显示 HIST3H3 抗体), and dynorphin-B in the striatum
NS5806 directly interacts with KChIP3 and modulates the interactions between this calcium-binding protein (显示 GUCA1B 抗体) and the T1 domain of the Kv4.3 (显示 KCND3 抗体) channels through reorientation of helix 10 on KChIP3
studies define the critical opposing functions of DREAM and USF1 (显示 USF1 抗体) in inhibiting and inducing A20 (显示 TNFAIP3 抗体) expression
Expression of DREAM in neuroblastoma (显示 ARHGEF16 抗体) cells enhances cisplatin mediated caspase-3 (显示 CASP3 抗体) activity.
Restoring CANT1 (显示 CANT1 抗体) levels in neuroblastoma (显示 ARHGEF16 抗体) clones recovered the phenotype, thus confirming a key role of CANT1 (显示 CANT1 抗体), and of the regulation of its gene by DREAM, in the control of protein synthesis and degradation
In cardiomyocytes, [Ca2 (显示 CA2 抗体)+]i-activated calmodulin kinase II (CaMKII (显示 CAMK2 抗体)) activates downstreamregulatory element (DRE (显示 SUFUH 抗体)) binding transcription factor DREAM, which consequently suppresses the expression of L-type calcium channel 1C-subunit gene (Cacna1c (显示 CACNA1C 抗体)).
zebrafish calsenilin is involved in endocrine cell differentiation and morphogenesis within the pancreas
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.
A-type potassium channel modulatory protein 3
, DRE-antagonist modulator
, calsenilin, presenilin-binding protein, EF hand transcription factor
, kv channel-interacting protein 3
, potassium channel interacting protein 3
, calsenilin, presenilin binding protein, EF hand transcription factor
, A-type potassium channel modulating protein 3
, calsenilin presenilin-binding protein EF hand transcription factor
, calsenilin, presenilin-binding protein, EF hand transcription fa
, downstream regulatory element-antagonist modulator
, Kv channel interacting protein 3, calsenilin