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KLF14 encodes a member of the Kruppel-like family of transcription factors. 再加上，我们可以发KLF14 抗体 (27) 和 KLF14 试剂盒 (17)和数多这个蛋白质的别的产品。
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SNPs at the CETP (显示 CETP 蛋白), HNF4A (显示 HNF4A 蛋白) and KLF14 (显示 SP6 蛋白) locus are associated with HDL (显示 HSD11B1 蛋白)-C levels and type 2 diabetes (in female participants).
KLF14 (显示 SP6 蛋白) plays an important role in increasing glucose uptake and insulin (显示 INS 蛋白) sensitivity by the activation of PI3-kinase (显示 PIK3CA 蛋白)/Akt (显示 AKT1 蛋白) signaling pathway in vitro.
KLF14 (显示 SP6 蛋白) transcription is significantly downregulated, whereas Plk4 transcription is upregulated in multiple types of cancers, and there exis (显示 SP6 蛋白)ts an inverse correlation between KLF14 and Plk4 protein expression in human breast and colon cancers.
Trans (显示 SP6 蛋白)duction of HepG2 cells with human KLF14 showed that KLF14 is a regu (显示 SP6 蛋白)lator of APOA1 expres (显示 HSD11B1 蛋白)sion.
The risk allele C of rs151290 in KCNQ1 (显示 KCNQ1 蛋白) and risk allele G of rs972283 in KLF14 (显示 SP6 蛋白) were both associated with increased risk of T2DM in a global population.
This is the first description of the activity and mechanisms underlying the function of KLF14 (显示 SP6 蛋白) as an activator protein and novel regulator of lipid signaling.
The objective of the present study was to detect the association of the rs4731702 single nucleotide polymorphism (SNP) and serum lipid levels in the Guangxi Mulao and Han populations.
we show that the type 2 diabetes and high-density lipoprotein cholesterol-associated cis (显示 CISH 蛋白)-acting expression quantitative trait locus (eQTL (显示 EQTN 蛋白)) of the maternally expressed transcription factor KLF14 (显示 SP6 蛋白) acts as a master trans regulator of adipose gene expression
KLF14 (显示 SP6 蛋白) gene is imprinted, with preferential expression from the maternal allele.
the TGFbeta (显示 TGFB1 蛋白) pathway activation leads to recruitment of a KLF14 (显示 SP6 蛋白)-mSin3A-HDAC2 (显示 HDAC2 蛋白) repressor complex to the TGFbetaRII promoter, as well as the remodeling of chromatin to increase histone marks that associate with transcriptional silencing.
these data provide proof of concept that deregulation of KLF14 (显示 SP6 蛋白)/PLK1 cascade plays a key role in thrombin (显示 F2 蛋白)-induced endothelial dysfunction in type 2 diabetes mellitus
DNA methylation (显示 HELLS 蛋白) at Klf14 (显示 SP6 蛋白) regulated mRNA expressions, which were downstream and inflammation genes in the adipose tissue. The methylation level of KLF14 (显示 SP6 蛋白) supposed to predict inflammatory change in the adipose tissue as epigenetic biomarker in the whole blood.
Klf14 (显示 SP6 蛋白) is not expressed in adult liver and its deletion does not affect plasma HDL (显示 HSD11B1 蛋白)-cholesterol concentration and other diet-induced obesity phenotypes in male mice. Klf14 (显示 SP6 蛋白) is highly expressed in mouse adenohypophysis and KLF14 (显示 SP6 蛋白) loss of function impacts on the pituitary transcriptome.
These data demonstrate an important role for KLF14 (显示 SP6 蛋白) expression in atherosclerotic lesion formation.
KLF14 (显示 SP6 蛋白) reduction serves as a mechanism leading to centrosome amplification and tumorigenesis. On the other hand, forced expression of KLF14 (显示 SP6 蛋白) leads to mitotic catastrophe.
KLF14 (显示 SP6 蛋白) is dysregulated in the liver of 2 dyslipidemia mouse models. KLF14 (显示 SP6 蛋白) regulates plasma HDL (显示 HSD11B1 蛋白)-C levels and cholesterol efflux capacity by modulating hepatic ApoA-I (显示 APOA1 蛋白) production. Hepatic-specific Klf14 (显示 SP6 蛋白) deletion in mice decreased circulating HDL (显示 HSD11B1 蛋白)-C levels.
The presence of progesterone induced the gene expression of egr-1 (显示 EGR1 蛋白) and also KLF14 (显示 SP6 蛋白), indicating that this steroid channels the signaling pathway into a non-canonical mechanism.
KLF14 (显示 SP6 蛋白) gene is intronless, and is monoallelically expressed from the maternal allele in both human and mouse.
This gene encodes a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2.
BTE-binding protein 5
, Krueppel-like factor 14
, basic transcription element-binding protein 5
, transcription factor BTEB5
, LOW QUALITY PROTEIN: Krueppel-like factor 14