Kruppel-Like Factor 14 蛋白 (KLF14)

KLF14 encodes a member of the Kruppel-like family of transcription factors. 再加上,我们可以发KLF14 抗体 (27)KLF14 试剂盒 (17)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
KLF14 136259 Q8TD94
KLF14 619665 Q19A41
大鼠 KLF14 KLF14 312203  
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
酵母菌 Chimpanzee His tag   1 mg Log in to see 60至71个工作日

KLF14 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
Mouse (Murine)

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Human Kruppel-Like Factor 14 (KLF14) interaction partners

  1. SNPs at the CETP, HNF4A and KLF14 locus are associated with HDL-C levels and type 2 diabetes (in female participants).

  2. KLF14 plays an important role in increasing glucose uptake and insulin sensitivity by the activation of PI3-kinase/Akt signaling pathway in vitro.

  3. KLF14 transcription is significantly downregulated, whereas Plk4 transcription is upregulated in multiple types of cancers, and there exists an inverse correlation between KLF14 and Plk4 protein expression in human breast and colon cancers.

  4. Transduction of HepG2 cells with human KLF14 showed that KLF14 is a regulator of APOA1 expression.

  5. The risk allele C of rs151290 in KCNQ1 and risk allele G of rs972283 in KLF14 were both associated with increased risk of T2DM in a global population.

  6. This is the first description of the activity and mechanisms underlying the function of KLF14 as an activator protein and novel regulator of lipid signaling.

  7. The objective of the present study was to detect the association of the rs4731702 single nucleotide polymorphism (SNP) and serum lipid levels in the Guangxi Mulao and Han populations.

  8. we show that the type 2 diabetes and high-density lipoprotein cholesterol-associated cis-acting expression quantitative trait locus (eQTL) of the maternally expressed transcription factor KLF14 acts as a master trans regulator of adipose gene expression

  9. KLF14 gene is imprinted, with preferential expression from the maternal allele.

  10. the TGFbeta pathway activation leads to recruitment of a KLF14-mSin3A-HDAC2 repressor complex to the TGFbetaRII promoter, as well as the remodeling of chromatin to increase histone marks that associate with transcriptional silencing.



This gene encodes a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2.

Gene names and symbols associated with Kruppel-Like Factor 14 蛋白 (KLF14)

  • Kruppel like factor 14 (KLF14)
  • Kruppel-like factor 14 (Klf14)
  • Kruppel like factor 14 (Klf14)
  • 5330411L03Rik 蛋白
  • AL022736 蛋白
  • BTEB5 蛋白

Protein level used designations for Kruppel-Like Factor 14 蛋白 (KLF14)

BTE-binding protein 5 , Krueppel-like factor 14 , basic transcription element-binding protein 5 , transcription factor BTEB5 , LOW QUALITY PROTEIN: Krueppel-like factor 14

136259 Homo sapiens
100345494 Oryctolagus cuniculus
482254 Canis lupus familiaris
100174956 Sus scrofa
619665 Mus musculus
312203 Rattus norvegicus
785436 Bos taurus
100727151 Cavia porcellus
735419 Pan troglodytes
106502050 Capra hircus
105607536 Ovis aries musimon
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