Insulin-Degrading Enzyme 蛋白 (IDE)

IDE encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. 再加上,我们可以发Insulin-Degrading Enzyme 抗体 (162)Insulin-Degrading Enzyme 试剂盒 (58)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
IDE 15925  
IDE 25700 P35559
IDE 3416 P14735
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
大肠杆菌(E. Coli) His tag,T7 tag 100 μg Log in to see 15至18个工作日
人细胞 His tag   50 μg Log in to see 4 Days
HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
小麦胚 GST tag 10 μg Log in to see 11至12个工作日
人细胞 His tag   10 μg Log in to see 15至16个工作日
大肠杆菌(E. Coli) 大鼠 非结合性   100 μg Log in to see 11至18个工作日
大肠杆菌(E. Coli) 非结合性   5 applications Log in to see 1至2个工作日

IDE 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine) ,

Rat (Rattus)
Human , , , ,
, , ,

引用最多的Insulin-Degrading Enzyme 蛋白

  1. Human IDE Protein expressed in HEK-293 Cells - ABIN2723516 : Kim, Lone, Saghatelian: Analysis of the proteolysis of bioactive peptides using a peptidomics approach. in Nature protocols 2013 (PubMed)

更多Insulin-Degrading Enzyme (IDE)互动伙伴

Mouse (Murine) Insulin-Degrading Enzyme (IDE) interaction partners

  1. Study indicated that, in the type 2 diabetes (T2D) and Alzheimer's disease (AD) mice, cAMP/PKA signaling pathway and IDE may participate in the contribute role of T2D in accelerating the pathological process of AD via causing neuronal apoptosis.

  2. Our results found that, in the mice with T2D and AD, the activators of PPARg/AMPK signaling pathway significantly increased the expression level of IDE, and decreased the accumulation of Ab40 and Ab42, as well as alleviated the spatial learning and recognition impairments.

  3. elevated IDE expression, in the skeletal muscle, seems to be mediated by activation of AMPK-ACC pathway, in response to exercise

  4. IDE inhibition did notincrease amyloid formation or beta-cell loss.

  5. This study demonstrated that the Decreased IDE and IGF2 expression in the cerebral cortex of pups by early life lead exposure.

  6. Findings show a key role of Pla2g3 on the reduction of IDE, and suggest that cerebrum specific increase of Pla2g3 is involved in the initiation and/or progression of Alzheimer disease.

  7. Abeta level reduction by CALHM1 could be explained by an increase in extracellular Abeta degradation by insulin-degrading enzyme.

  8. Data suggest that protein restriction down-regulates expression of insulysin (insulin degrading enzyme) in liver and subsequently reduced insulin clearance.

  9. IDE deficiency in bone marrow-derived cells results in larger atherosclerotic lesions, increased lesion-associated Abeta and RAGE, and higher serum cholesterol in male, Ldlr(-/-) mice.

  10. The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of alpha-synuclein levels in beta-cells.

  11. this study identified an upstream promoter element which blocks the reverse transcription of mouse IDE.

  12. Data show that in the absence of insulin-degrading enzyme (IDE), full-length calcitonin gene-related peptide (CGRP) levels are elevated in vivo.

  13. role played by somatostatin in preventing Abeta accumulation by partially restoring IDE activity

  14. These data suggest that NOS2 upregulation impairs amyloid beta degradation through negative regulation of insulin degrading enzyme

  15. BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).

  16. The diabetic phenotype in IDE-KO mice is not a primary consequence of IDE deficiency, but is instead an emergent compensatory response to chronic hyperinsulinemia resulting from complete deletion of IDE.

  17. The combined data indicate that the non-conventional secretion of IDE is regulated by the newly identified SlyX motif.

  18. Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated IDE.

  19. Proteolytically-active plasma membrane associated-insulin degrading enzyme is routed in living neuroblastoma cells to multivesicular bodies and subsequently, a major fraction is sorted to exosomes.

  20. Knockout mice show abnormal levels of insulin, amyloid beta protein and ABPP in vivo.

Human Insulin-Degrading Enzyme (IDE) interaction partners

  1. These results support the hypothesis that IDE gene expression in different areas of Alzheimer's patient's brains.

  2. People with allelic variation in four genes related to cardiovascular diseases and metabolism were more likely to die: apolipoprotein (APO)C1 GG and AG carriers, APOE varepsilon4 carriers, insulin-degrading enzyme (IDE) TC carriers, and phosphatidylinositol 3-kinase (PI3KCB) GG carriers.

  3. Data suggest the possibility of development of insulin-degrading enzyme (IDE)-based drugs for the treatment of the late-onset form of Alzheimer's disease (AD).

  4. the mechanistic and molecular features of IDE-26S proteasome interaction in a cell experimental model, is reported.

  5. No significant associations have been found between other IDE gene single nucleotide polymorphisms of rs4646953, rs2251101 and rs1544210 with Alzheimer disease.

  6. results demonstrate that the polymorphisms rs1887922 and rs1999764 of the IDE gene are associated with late-onset Alzheimer disease susceptibility in the Xinjiang Han population

  7. Cognitive impairment is more frequent among those exposed to the C allele of the rs2209972 SNP of the insulin degrading enzyme gene.

  8. IDE does not play a major role in MHC class I antigen processing, confirming the dominant and almost exclusive role of the proteasome in cytosolic production of MHC class I ligands.

  9. using combinational in silico investigations, study identified that pathogenic nonsynonymous mutations corresponding to p.I54F, p.P122T, p.T533R, p.P581A and p.Y609A have more potential role in structural and functional deviations of IDE activity

  10. Our study provided evidence to IDE, PON1, WFS1, POU2F1, IL1alpha and IL1beta associated with T2D in Pakistanis.

  11. An upstream promoter element which blocks the antisense transcription of the human IDE promoter, was identified.

  12. Both IDE and type 2 diabetes are associated with executive function levels in older adults

  13. Conformational changes in IDE, including a swinging-door mechanism that permits the entry of short peptides into the catalytic chamber, governs the selective destruction of amyloidogenic peptides.

  14. for the rs1832196 polymorphism, significant association with Alzheimer disease was found by the dominant model in overall and subgroup analysis.

  15. In conclusion, this epistatic interaction showed a high degree of consistency when stratifying by sex, the epsilon4 allele of apolipoprotein E genotype, and geographic region.

  16. IDE-Met(1) links the mitochondrial biogenesis pathway with mitAbeta levels and organelle functionality.

  17. Genetic variants for both insulin degrading enzyme (IDE) and angiotensin converting enzyme (ACE) in relation to cognitive phenotype.

  18. In the context of APOEepsilon4-negative status, insulin-degrading enzyme variants are significantly associated with Alzheimer disease in some genetic models.

  19. The polymorphism of insulin-degrading enzyme is associated with susceptibility to Alzheimer's disease in Han Chinese.

  20. Data suggest that HEs-1/Hey-1 transcriptional modulation of insulin degrading enzyme may impact amyloid beta metabolism by providing a functional link between Notch signaling and the amyloidogenic pathway.

蛋白简介Insulin-Degrading Enzyme (IDE)


This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

Gene names and symbols associated with Insulin-Degrading Enzyme 蛋白 (IDE)

  • insulin degrading enzyme (IDE)
  • insulin-degrading enzyme (ide)
  • insulin-degrading enzyme (LOC591315)
  • insulin-degrading enzyme (CC1G_01115)
  • insulin-degrading enzyme (Bm1_26615)
  • insulin-degrading enzyme (PTRG_10875)
  • metallopeptidase (SJAG_01430)
  • insulin-degrading enzyme (EBI_21700)
  • insulin-degrading enzyme (VDBG_06702)
  • insulin-degrading enzyme (LOAG_08082)
  • insulin-degrading enzyme (PGTG_04982)
  • insulin-degrading enzyme (Tsp_00424)
  • insulin degrading enzyme (Ide)
  • 1300012G03Rik 蛋白
  • 4833415K22Rik 蛋白
  • AA675336 蛋白
  • AI507533 蛋白
  • IDE 蛋白
  • INSDEGM 蛋白
  • zgc:162603 蛋白

Protein level used designations for Insulin-Degrading Enzyme 蛋白 (IDE)

insulysin , insulin-degrading enzyme , insulin-degrading enzyme-like , insulin protease , insulinase , Abeta-degrading protease

450608 Pan troglodytes
561390 Danio rerio
591315 Strongylocentrotus purpuratus
698640 Macaca mulatta
6009544 Coprinopsis cinerea okayama7130
6100223 Brugia malayi
6349187 Pyrenophora tritici-repentis Pt-1C-BFP
7051385 Schizosaccharomyces japonicus yFS275
8641122 Enterocytozoon bieneusi H348
9537184 Verticillium alfalfae VaMs.102
100071303 Equus caballus
100385143 Callithrix jacchus
100434053 Pongo abelii
100482236 Ailuropoda melanoleuca
9945508 Loa loa
10530847 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10901673 Trichinella spiralis
15925 Mus musculus
25700 Rattus norvegicus
3416 Homo sapiens
477768 Canis lupus familiaris
100341888 Oryctolagus cuniculus
100719651 Cavia porcellus
423814 Gallus gallus
100155309 Sus scrofa
523752 Bos taurus
101104194 Ovis aries
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