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HCST encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. 再加上，我们可以发HCST 试剂盒 (8) 和 HCST 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal HCST Primary Antibody for ELISA, WB - ABIN188679
Upshaw, Arneson, Schoon, Dick, Billadeau, Leibson: NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. in Nature immunology 2006
These results suggest that NKG2D (显示 KLRK1 抗体)-DAP10 endocytosis represents a means to decrease cell surface receptor abundance, as well as to control signaling outcome in cytotoxic lymphocytes.
findings indicate that the functional interaction between RAGE (显示 AGER 抗体) and DAP10 coordinately regulates S100A8 (显示 S100A8 抗体)/A9-mediated survival and/or apoptotic response of keratinocytes
TGF-beta1 (显示 TGFB1 抗体) may reduce the expression of NKG2D (显示 KLRK1 抗体)/DAP10 and 2B4 (显示 CD244 抗体)/SAPin patients with hepatitis B.
HMBOX1 (显示 HMBOX1 抗体) negatively regulates the expression of NKG2D (显示 KLRK1 抗体) and the activation of the NKG2D (显示 KLRK1 抗体)/DAP10 signaling pathway in NK cells.
Other gamma(c) cytokines act similarly to IL-2 (显示 IL2 抗体) in up-regulating DAP10 expression and NKG2D (显示 KLRK1 抗体)-DAP10 surface expression.
TGF-BETA1 (显示 TGFB1 抗体) down-modulates surface NKG2D (显示 KLRK1 抗体) expression by controlling the transcriptional and translational levels of DAP10.
A transgenic mouse model demonstrates that induction of tolerance in Ly49H-positive natural killer (NK) cells by chronic exposure to virus-encoded ligand m157 requires signaling through the Ly49H adaptor protein DAP12 (显示 TYROBP 抗体), not the DAP10 adaptor protein.
NKG2D (显示 KLRK1 抗体)-DAP10 triggers human NK cell-mediated killing via a Syk (显示 SYK 抗体)-independent regulatory pathway.
both activated and expanded CD8 (显示 CD8A 抗体)+ T cells and NK cells use DAP10 for cytolysis
Downstream targets of DAP10 and DAP12 (显示 TYROBP 抗体) are constitutively activated in large granular lymphocyte leukemia cells, and expression of dominant-negative DAP10 and DAP12 (显示 TYROBP 抗体) dramatically reduces their lytic capacity.
Adoptive transfer of murine T cells expressing a chimeric-PD1 (显示 PDCD1 抗体)-Dap10 receptor may induce a preferential cytokine profile and T-cell differentiation phenotype for anti-lymphoma therapies.
Rat and mouse CD94 (显示 KLRD1 抗体)/NKG2C (显示 KLRC2 抗体) heterodimers bind efficiently to both DAP12 (显示 TYROBP 抗体) and DAP10; this binding is critically dependent on the transmembrane lysine residue of CD94 (显示 KLRD1 抗体).
contributes to CD8 (显示 CD8A 抗体)(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection
demonstrate a previously uncharacterized interaction of SHIP1 (显示 INPP5D 抗体) with DAP12 (显示 TYROBP 抗体) that limits TREM2 (显示 TREM2 抗体)- and DAP12 (显示 TYROBP 抗体)-dependent signaling and identify a mechanism through which SHIP1 (显示 INPP5D 抗体) regulates key ITAM-containing receptors by blocking the binding and activation of PI3K
selective associations with DAP10 determine stimulatory versus costimulatory activity of NKG2D (显示 KLRK1 抗体)
Differential requirements for Vav (显示 VAV1 抗体) proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.
The importance of Fcgr3 (显示 CD16 抗体)/Cd3z (显示 CD247 抗体), Hcst, and Tyrobp (显示 TYROBP 抗体) in the activation of NK cells in the uterus of pregnant mice is reported.
Review of immune reactions against syngeneic tumors reveals an important physiological role of DAP10 adapter protein (显示 GRB10 抗体) signaling in maintaining tolerance to self, by controlling the development and activation threshold of autoreactive T cells.
DAP10 signaling is involved in adjusting the activation threshold and generation of natural killer T cells and regulatory T cells to avoid autoreactivity, but it also modulates antitumor mechanisms.
improved rejection of B16 melanomas in DAP10-deficient mice
The structure of the adaptor protein dap10 has been identified in the zebrafish genome.
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.
DNAX-activation protein 10
, kinase assoc pro of ~10kDa
, kinase assoc protein
, membrane protein DAP10
, phosphoinositide-3-kinase adaptor protein
, transmembrane adapter protein KAP10
, immunoreceptor DAP10
, hematopoietic cell signal transducer
, putative membrane adaptor molecule
, hematopoietic cell signal transducer A
, hematopoietic cell signal transducer L homeolog
, signal subunit, signaling transmembrane co-receptor