蛋白简介

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.

Gene names and symbols associated with GFI1

• growth factor independent 1 (Gfi1) 抗体
• growth factor independent 1 transcriptional repressor (GFI1) 抗体
• growth factor independent 1 transcriptional repressor (Gfi1) 抗体

• AW495828 抗体
• GFI-1 抗体
• GFI1 抗体
• GFI1A 抗体
• Pal-1 抗体
• 显示所有的同义词和别名
• Pal1 抗体
• SCN2 抗体
• ZNF163 抗体

Protein level used designations for GFI1

growth factor independent protein 1 , zinc finger protein Gfi-1 , growth factor independent 1 , Growth factor independent-1 , growth factor independence-1 , zinc finger protein 163 , growth factor independence 1