Glutathione S-Transferase mu 3 (Brain) 蛋白 (GSTM3)

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. 再加上,我们可以发Glutathione S-Transferase mu 3 (Brain) 抗体 (65)Glutathione S-Transferase mu 3 (Brain) 试剂盒 (5)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
GSTM3 2947 P21266
GSTM3 14864 P19639
大鼠 GSTM3 GSTM3 108348148 Q9Z1B2;
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大肠杆菌(E. Coli) 非结合性 100 μg 2至3个工作日
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30至35个工作日
$5,370.21
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大肠杆菌(E. Coli) His tag,T7 tag 100 μg 15至18个工作日
$560.00
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小麦胚 GST tag 10 μg 11至12个工作日
$340.00
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大肠杆菌(E. Coli) His tag 100 μg 15至19个工作日
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GSTM3 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, ,
Mouse (Murine)

更多Glutathione S-Transferase mu 3 (Brain) (GSTM3)互动伙伴

Human Glutathione S-Transferase mu 3 (Brain) (GSTM3) interaction partners

  1. ROS production is one mechanism by which cancer drugs kill tumour cells, and according to our evidence, GSTM3 may play an important role in preventing breast cancer treatment-induced cellular cytotoxicity

  2. Differential activity of antioxidant enzymes caused by the polymorphism in GSTM3 may contribute to resistance to hormonal therapy through oxidative stress. The GSTM3 rs7483 polymorphism may be a promising biomarker for prostate cancer patients treated with androgen-deprivation therapy (ADT)

  3. The individuals carrying the deletions of GSTM1 and GSTT1 were at risk for Neurocysticercosis (NCC). Genetic variants of GSTM3 and GSTP1 were not associated with NCC.

  4. Expression of GSTM3 might be regulated by epigenetic changes in lens tissue. Hypermethylation in GSTM3 promoter and altered histone modification might have a role in the ARC formation.

  5. This meta-analysis suggested that the GSTT1 and GSTM3 polymorphisms might influence osteosarcoma risk.

  6. No associations between the GSTT1, GSTP1, and GSTM3 genotypes and neoplasia risk were observed. In conclusion, we determined the genotype distribution of GST polymorphisms in control subjects and breast cancer patients from northeastern Mexico.

  7. NSD1 interacted with RNAPII and bound to GSTM3 -63A/C TATA box.

  8. To identify the genotypes of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 in a case-control study.

  9. All three markers correlated significantly with regional lymph node metastasis: FXYD3 (p = 0.0110), S100A11 (p = 0.0071), and GSTM3 (p = 0.0173) in colon cancer lymphatic metastasis.

  10. This meta-analysis suggests that the GSTM3 A/B polymorphism may be an important protective factor for head and neck cancer, especially of laryngeal cancer and Caucasian populations.

  11. rs1332018 genetic variants in the GSTM3 promoter predispose the host to downregulating GSTM3 expression in kidney, facilitate carcinogenesis, and predict an unfavourable postoperative prognosis of renal cell carcinoma.

  12. In conclusion, this epistatic interaction showed a high degree of consistency when stratifying by sex, the epsilon4 allele of apolipoprotein E genotype, and geographic region.

  13. The GSTM3 A/B gene polymorphism is not associated with lung cancer susceptibility.

  14. Methylation of GSTM3 promoter may contribute to oxidative stress-associated liver damage and correlate with the disease severity in Acute-on-chronic hepatitis B liver failure.

  15. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.

  16. There were no significant differences in distribution of 3-bp deletion polymorphism in intron 6 variant allele in Glutathione-S-transferase M3 between chronic obstructive pulmonary disease patients and controls in a north Indian population.

  17. This study aims to investigate the genotype frequencies of GSTM1, GSTT1 and GSTM3 genes in 80 osteosarcoma patients and 160 normal control participants, and also the influence of these polymorphisms in the clinical outcome of osteosarcoma patients.

  18. In individuals from Angola, Mozambique and the Sao Tome e Principe islands, the GSTM3*B allele was three times more frequent (0.74-0.78) than the GSTM3*A allele (0.22-0.26), with no significant differences in allele frequency across the three groups.

  19. single-nucleotide polymorphisms/haplotypes in the GSTM3 gene within the GSTMs gene cluster are likely to contribute to breast cancer risk when the GSTM1 is absent

  20. Diminished GSTM3 mRNA levels correlated with decreased minichromosome maintenance deficient 3 (MCM3) mRNA levels in a diagnostic and SNP-dependent fashion in Alzheimer disease.

Mouse (Murine) Glutathione S-Transferase mu 3 (Brain) (GSTM3) interaction partners

  1. Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 regulation: cytochrome CYP2A5, GSTM3, GSTM1, ENTPD5,UDPGDH, and EPHX1.

  2. Data show that beta-catenin accumulation increases GST activity in nuclei of HCC cells, and suggest that GSTM3 may be a novel target gene of the beta-catenin/Tcf-Lef complex.

蛋白简介Glutathione S-Transferase mu 3 (Brain) (GSTM3)

蛋白简介

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with GSTM3

  • glutathione S-transferase mu 3 (GSTM3)
  • glutathione S-transferase Mu 3 (GSTM3)
  • glutathione S-transferase, mu 3 (Gstm3)
  • glutathione S-transferase Mu 3 (LOC479911)
  • glutathione S-transferase mu 3 (Gstm3)
  • Fsc2 蛋白
  • GST5 蛋白
  • GSTB 蛋白
  • GSTM3-3 蛋白
  • GTM3 蛋白
  • mGSTM5 蛋白

Protein level used designations for GSTM3

GST class-mu 3 , S-(hydroxyalkyl)glutathione lyase M3 , brain GST , brain type mu-glutathione S-transferase , glutathione S-alkyltransferase M3 , glutathione S-aralkyltransferase M3 , glutathione S-aryltransferase M3 , glutathione S-transferase M3 (brain) , glutathione S-transferase Mu 3 , glutathione S-transferase, Mu-3 , hGSTM3-3 , glutathione S-transferase M3 , glutathione S-transferase GT9.3 , glutathione S-transferase mu 3 , glutathione-S-transferase, mu , glutathione S-transferase Mu 3-like , glutathione S-transferase Mu 5 , GST class-mu 5

GENE ID SPECIES
2947 Homo sapiens
100169963 Felis catus
14864 Mus musculus
615507 Bos taurus
457128 Pan troglodytes
479911 Canis lupus familiaris
700303 Macaca mulatta
100061826 Equus caballus
100514231 Sus scrofa
100356052 Oryctolagus cuniculus
100732625 Cavia porcellus
102188913 Capra hircus
108348148 Rattus norvegicus
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