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Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. 再加上，我们可以发Glutathione S-Transferase mu 3 (Brain) 抗体 (57) 和 Glutathione S-Transferase mu 3 (Brain) 试剂盒 (5)和数多这个蛋白质的别的产品。
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Differential activity of antioxidant enzymes caused by the polymorphism in GSTM3 may contribute to resistance to hormonal therapy through oxidative stress. The GSTM3 rs7483 polymorphism may be a promising biomarker for prostate cancer patients treated with androgen-deprivation therapy (ADT)
The individuals carrying the deletions of GSTM1 (显示 GSTM1 蛋白) and GSTT1 (显示 GSTT1 蛋白) were at risk for Neurocysticercosis (NCC (显示 SLC12A3 蛋白)). Genetic variants of GSTM3 and GSTP1 (显示 GSTP1 蛋白) were not associated with NCC (显示 SLC12A3 蛋白).
Expression of GSTM3 might be regulated by epigenetic changes in lens tissue. Hypermethylation in GSTM3 promoter and altered histone modification might have a role in the ARC (显示 NOL3 蛋白) formation.
This meta-analysis suggested that the GSTT1 (显示 GSTT1 蛋白) and GSTM3 polymorphisms might influence osteosarcoma risk.
No associations between the GSTT1, GSTP1, and GSTM3 genotypes and neoplasia risk were observed. In conclusion, we determined the genotype distribution of GST polymorphisms in control subjects and breast cancer patients from northeastern Mexico.
NSD1 interacted with RNAPII and bound to GSTM3 -63A/C TATA box.
To identify the genotypes of CYP1A1 (显示 CYP1A1 蛋白), GSTM1 (显示 GSTM1 蛋白), GSTM3, GSTT1 (显示 GSTT1 蛋白) and GSTP1 (显示 GSTP1 蛋白) in a case-control study.
All three markers correlated significantly with regional lymph node metastasis: FXYD3 (显示 FXYD3 蛋白) (p = 0.0110), S100A11 (显示 S100A11 蛋白) (p = 0.0071), and GSTM3 (p = 0.0173) in colon cancer lymphatic metastasis.
This meta-analysis suggests that the GSTM3 A/B polymorphism may be an important protective factor for head and neck cancer, especially of laryngeal cancer and Caucasian populations.
rs1332018 genetic variants in the GSTM3 promoter predispose the host to downregulating GSTM3 expression in kidney, facilitate carcinogenesis, and predict an unfavourable postoperative prognosis of renal cell carcinoma (显示 MOK 蛋白).
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 (显示 NFE2L2 蛋白) regulation: cytochrome CYP2A5, GSTM3, GSTM1 (显示 GSTM1 蛋白), ENTPD5 (显示 ENTPD5 蛋白),UDPGDH (显示 UGDH 蛋白), and EPHX1 (显示 EPHX1 蛋白).
Data show that beta-catenin (显示 CTNNB1 蛋白) accumulation increases GST activity in nuclei of HCC (显示 FAM126A 蛋白) cells, and suggest that GSTM3 may be a novel target gene of the beta-catenin (显示 CTNNB1 蛋白)/Tcf (显示 HNF4A 蛋白)-Lef complex.
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants.
GST class-mu 3
, S-(hydroxyalkyl)glutathione lyase M3
, brain GST
, brain type mu-glutathione S-transferase
, glutathione S-alkyltransferase M3
, glutathione S-aralkyltransferase M3
, glutathione S-aryltransferase M3
, glutathione S-transferase M3 (brain)
, glutathione S-transferase Mu 3
, glutathione S-transferase, Mu-3
, glutathione S-transferase M3
, glutathione S-transferase GT9.3
, glutathione S-transferase mu 3
, glutathione-S-transferase, mu
, glutathione S-transferase Mu 3-like
, glutathione S-transferase Mu 5
, GST class-mu 5